Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Yong-Juan Zhao"'
Publikováno v:
Biology, Vol 13, Iss 9, p 649 (2024)
Glioblastoma, a formidable brain tumor characterized by dysregulated NAD metabolism, poses a significant therapeutic challenge. The NAMPT inhibitor FK866, which induces NAD depletion, has shown promise in controlling tumor proliferation and modifying
Externí odkaz:
https://doaj.org/article/32fdaae86ab346a5864c2d5bdc47372f
Autor:
Yun Nan Hou, Yang Cai, Wan Hua Li, Wei Ming He, Zhi Ying Zhao, Wen Jie Zhu, Qiang Wang, Xinyi Mai, Jun Liu, Hon Cheung Lee, Goran Stjepanovic, Hongmin Zhang, Yong Juan Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
SARM1 is a key player in axon degeneration. Here, the authors generate a nanobody, which specifically recognizes the NMN-bound state of SARM1 and helps resolve the SARM1 structure in an intermediate state of activation.
Externí odkaz:
https://doaj.org/article/7ac80b9e728148edbeca55b6a3fc6886
Autor:
Yu Zhang, Bu-ting Duan, Yong-juan Zhao, Kai-ling Cui, Tong Xu, Xue-song Zhang, Xiao-ling Lv, Lu-Lu Guo, Ming-xue Zheng, Rui Bai
Publikováno v:
Poultry Science, Vol 102, Iss 4, Pp 102535- (2023)
ABSTRACT: Eimeria tenella mainly invades and develops into cecal epithelial cells of chickens, resulting in cecal epithelial cell damage. Infectious intracellular pathogens possibly act by influencing the autophagy process after invading cells. The i
Externí odkaz:
https://doaj.org/article/9b1f50dab2814d02b8d8ee79eda98b47
Publikováno v:
Journal of Integrative Agriculture, Vol 21, Iss 9, Pp 2615-2627 (2022)
Malus prunifolia Borkh. ‘Fupingqiuzi’ has significant ecological and economic value and plays a key role in germplasm development and resistance research. However, its long juvenile phase and high heterozygosity are barriers to the identification
Externí odkaz:
https://doaj.org/article/05a8deb1e74741a7a009a77110af2310
Autor:
Elodie Duray, Margaux Lejeune, Frederic Baron, Yves Beguin, Nick Devoogdt, Ahmet Krasniqi, Yoline Lauwers, Yong Juan Zhao, Matthias D’Huyvetter, Mireille Dumoulin, Jo Caers
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-13 (2021)
Abstract Background Antibody-based therapies targeting CD38 are currently used as single agents as well as in combination regimens for multiple myeloma, a malignant plasma cell disorder. In this study, we aimed to develop anti-CD38 single-domain anti
Externí odkaz:
https://doaj.org/article/6b141013e0604fe3b0f374aa12371db3
Autor:
Xue-song Zhang, Yong-juan Zhao, Yu Zhang, Tong Xu, Kai-ling Cui, Bu-ting Duan, Xiao-ling Lv, Li Zhang, Zhi-yong Xu, Rui Bai, Ming-xue Zheng
Publikováno v:
Poultry Science, Vol 101, Iss 10, Pp 102075- (2022)
This study aimed to explore the role and key point of EtMIC4 EGF-like recombinant protein in regulating the apoptosis of Eimeria tenella host cells via the epidermal growth factor receptor (EGFR) pathway. The cells were treated with EtMIC4 EGF-like p
Externí odkaz:
https://doaj.org/article/926f67079b5e4395a2c583a03fa8d3ce
Autor:
Xiao-Ling Lv, Yong-Yan Wang, Ming-Xue Zheng, Rui Bai, Li Zhang, Bu-Ting Duan, Xuan Lei, Xue-Song Zhang, Yong-Juan Zhao, Kai-Ling Cui, Tong Xu
Publikováno v:
Poultry Science, Vol 101, Iss 7, Pp 101916- (2022)
ABSTRACT: Cecal epithelial cell damage is a key factor in host injure during the development of E. tenella. The intracellular free Ca2+ of the host cell is closely related to the invasion, development and proliferation of intracellular parasites, and
Externí odkaz:
https://doaj.org/article/f0a0eb4e3ebb4c988099f3cad26ef3b7
Autor:
Ziyang Fu, Bin Huang, Jinle Tang, Shuyan Liu, Ming Liu, Yuxin Ye, Zhihong Liu, Yuxian Xiong, Wenning Zhu, Dan Cao, Jihui Li, Xiaogang Niu, Huan Zhou, Yong Juan Zhao, Guoliang Zhang, Hao Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The SARS-CoV-2 papain-like protease (PLpro) is of interest as a drug target. Here, the authors identify GRL0617 as a PPI (protein–protein interaction) inhibitor of SARS-CoV-2 PLpro that inhibits its deISGylating activity and present the mechanism o
Externí odkaz:
https://doaj.org/article/e0b510d04f0846f9afbec3f3b04bc27e
Autor:
Xiao-min LIU, Teng-teng GAO, Zhi-jun ZHANG, Ke-xin TAN, Yi-bo JIN, Yong-juan ZHAO, Feng-wang MA, Chao LI
Publikováno v:
Journal of Integrative Agriculture, Vol 19, Iss 11, Pp 2709-2724 (2020)
Dopamine plays numerous physiological roles in plants. We explored its role in the regulation of growth, nutrient absorption, and response to nitrogen (N) deficiency in Malus hupehensis Rehd. Under low N condition, plant growth slowed, and the net ph
Externí odkaz:
https://doaj.org/article/ba73e0e5bbe14ba09977883c5e5b2d53
Autor:
Wan Hua Li, Ke Huang, Yang Cai, Qian Wen Wang, Wen Jie Zhu, Yun Nan Hou, Sujing Wang, Sheng Cao, Zhi Ying Zhao, Xu Jie Xie, Yang Du, Chi-Sing Lee, Hon Cheung Lee, Hongmin Zhang, Yong Juan Zhao
Publikováno v:
eLife, Vol 10 (2021)
SARM1 regulates axonal degeneration through its NAD-metabolizing activity and is a drug target for neurodegenerative disorders. We designed and synthesized fluorescent conjugates of styryl derivative with pyridine to serve as substrates of SARM1, whi
Externí odkaz:
https://doaj.org/article/ad4f471898f24bb6b9401388eb12196c