Výsledky vyhledávání - "Yong-Jiang Cao"

Expression of mutant non-cleavable Fas ligand on retrovirus packaging cells causes apoptosis of immunocompetent cells and improves prodrug activation gene therapy in a malignant glioma model

Autor: Yong-Jiang Cao, Ariel Quiñones, Christof M. Kramm, Nikolai G. Rainov, Karl-Ulrich Dobberstein, Constanze Nafe

Publikováno v: Life Sciences. 73:1847-1860

Recombinant retroviruses (RV) have been widely used as vectors for clinical gene therapy of malignant brain tumors. Because of the very limited stability of these vectors in vivo, RV producing cells (VPC) are routinely used for intratumoral RV releas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636a847321faecbebc9a3bc5079b9e8c
https://doi.org/10.1016/s0024-3205(03)00542-3

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A mutation in the second intracellular loop of the pituitary adenylate cyclase activating polypeptide type I receptor confers constitutive receptor activation

Autor: Yong-Jiang Cao, Falk Fahrenholz, Gerald Gimpl

Publikováno v: FEBS Letters. 469:142-146

The pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor belongs to the glucagon/secretin/vasoactive intestinal polypeptide (VIP) receptor family. We mutated and deleted an amino acid residue (E261) which is located within the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9dcd7136d8b9b29a8e96b3a64b23449
https://doi.org/10.1016/s0014-5793(00)01269-2

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Photoaffinity Labeling Analysis of the Interaction of Pituitary Adenylate-Cyclase-Activating Polypeptide (PACAP) with the PACAP Type I Receptor

Autor: Marek Jasionowski, Gerald Gimpl, Franciszek Kasprzykowski, Falk Fahrenholz, Elzbieta Kojro, Leszek Lankiewicz, Yong-Jiang Cao

Publikováno v: European Journal of Biochemistry. 244:400-406

To identify residues and domains of the peptide hormone pituitary adenylate-cyclase-activating polypeptide (PACAP) that interact with the type I receptor, two photoreactive analogues of PACAP-( 1-27)peptide were synthesized using solid-phase peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25a64e48ce9a3e2c862ace6a08f244d
https://doi.org/10.1111/j.1432-1033.1997.00400.x

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Molecular structure analysis of the pituitary adenylate cyclase activating polypeptide type I receptor from pig brain

Autor: Gerald Gimpl, Falk Fahrenholz, Yong-Jiang Cao

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1222:432-440

In pig brain a type I receptor for pituitary adenylate cyclase activating polypeptide (PACAP) has been identified and structurally characterized. Scatchard analysis of the equilibrium binding data indicates a single class of binding sites with Kd of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec4a0c168508c35fb3e0dff8d68f2f0
https://doi.org/10.1016/0167-4889(94)90051-5

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A constitutively active pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor shows enhanced photoaffinity labeling of its highly glycosylated form

Autor: Yong-Jiang Cao, Gerald Gimpl

Publikováno v: Biochimica et biophysica acta. 1548(1)

In the present study, we have analyzed a previously identified constitutively active pituitary adenylate cyclase activating polypeptide (PACAP) type I (PAC1) receptor with a deletion of the single amino acid residue Glu 261 (Y.-J. Cao, G. Gimpl, F. F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f7a5542400bee32cc855f87e37298d
https://pubmed.ncbi.nlm.nih.gov/11451447

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Production and characterization of monoclonal antibodies to pituitary adenylate cyclase activating polypeptide type I receptor

Autor: Aurelija Źvirblienë, Gintautas Źvirblis, Falk Fahrenholz, Yong-Jiang Cao

Publikováno v: Hybridoma. 18(4)

Pituitary adenylate cyclase activating polypeptide type I receptor (PACAPr) belongs to the novel subfamily of the G-protein coupled receptors with a long extracellular N-terminus, which functions as a major binding site for the PACAP. Three different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268262bdde6603f4627e64f1bab5f165
https://pubmed.ncbi.nlm.nih.gov/10571263

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Identification of binding domains of pituitary adenylate cyclase activating polypeptide (PACAP) for its type 1 receptor by photoaffinity labeling

Autor: Falk Fahrenholz, Elzbieta Kojro, Yong-Jiang Cao, Zbigniew Grzonka, Marek Jasionowski, Leszek Lankiewicz

Publikováno v: Annals of the New York Academy of Sciences. 865

Structure-function studies and photoaffinity labeling experiments were performed to identify residues and domains of PACAP involved in the interaction with PACAP receptors. For this purpose, a series of photoreactive analogues of PACAP(1-27) containi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a217588c6980a0ba746b705539ed443
https://pubmed.ncbi.nlm.nih.gov/9928000

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The amino-terminal fragment of the adenylate cyclase activating polypeptide (PACAP) receptor functions as a high affinity PACAP binding domain

Autor: Falk Fahrenholz, Gerald Gimpl, Yong-Jiang Cao

Publikováno v: Biochemical and biophysical research communications. 212(2)

The PACAP receptor represents a member of a novel subfamily of G-protein coupled receptors with a common structurally conserved extracellular domain of about 150 amino acids. We have addressed the question whether this extracellular amino-terminus of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4feff26405f291c51c0c45285f358207
https://pubmed.ncbi.nlm.nih.gov/7626082

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