Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Yong-Gang Fan"'
Autor:
Yong-Gang Fan, Ri-Le Ge, Hang Ren, Rong-Jun Jia, Ting-Yao Wu, Xian-Fang Lei, Zheng Wu, Xiao-Bei Zhou, Zhan-You Wang
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107404- (2024)
Increased astrocytic lactoferrin (Lf) expression was observed in the brains of elderly individuals and Alzheimer's disease (AD) patients. Our previous study revealed that astrocytic Lf overexpression improved cognitive capacity by facilitating Lf sec
Externí odkaz:
https://doaj.org/article/cfa83bbb3a8a40c299a52a2cb2da56fd
Autor:
Yong-Gang Fan, Ting-Yao Wu, Ling-Xiao Zhao, Rong-Jun Jia, Hang Ren, Wen-Jia Hou, Zhan-You Wang
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 107039- (2024)
Zinc is a crucial trace element in the human body, playing a role in various physiological processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair. The zinc transporters (ZnTs) family members are responsible for expor
Externí odkaz:
https://doaj.org/article/0edd1971273649bb8352175944f48a83
Autor:
Yong-Gang Fan, Tian Guo, Xiao-Ran Han, Jun-Lin Liu, Yu-Ting Cai, Han Xue, Xue-Shi Huang, Yan-Chun Li, Zhan-You Wang, Chuang Guo
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 393-407 (2019)
Background: Recent studies have revealed that vitamin D deficiency may increase the risk of Alzheimer's disease, and vitamin D supplementation may be effective strategy to ameliorate the neurodegenerative process in Alzheimer's disease patients. Pari
Externí odkaz:
https://doaj.org/article/6b0b3eb1928d4e40ad3de769a632d818
Autor:
Yan-hui Zhang, Xin-zhu Yan, Shuang-feng Xu, Zhong-qiu Pang, Lin-bo Li, Yang Yang, Yong-gang Fan, Zhuo Wang, Xin Yu, Chuang Guo, Qiang Ao
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
The microtubule-associated protein tau is closely correlated with hypometabolism in Alzheimer’s disease (AD). α-lipoic acid (LA), which is a naturally occurring cofactor in mitochondrial, has been shown to have properties that can inhibit the tau
Externí odkaz:
https://doaj.org/article/055675e7ef0d4f559e0e10904848b077
Autor:
Yan-Hui Zhang, Da-Wei Wang, Shuang-Feng Xu, Shuai Zhang, Yong-Gang Fan, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Zhan-You Wang, Chuang Guo
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 535-548 (2018)
Alzheimer's disease (AD) is the most common neurodegenerative disease and is characterized by neurofibrillary tangles (NFTs) composed of Tau protein. α-Lipoic acid (LA) has been found to stabilize the cognitive function of AD patients, and animal
Externí odkaz:
https://doaj.org/article/91db7d174dbb4aad95a06ad33f8c9534
Publikováno v:
International Journal of Ophthalmology, Vol 10, Iss 7, Pp 1040-1045 (2017)
AIM: To investigate the roles of PKC-α/ezrin signals in phagocytosis crisis of retinal pigment epithelium (RPE) cells in light damage model. METHODS: Light induced mice RPE injury model was established by continuously irradiating cool white light a
Externí odkaz:
https://doaj.org/article/85149b640e374b5eb27f0bb5c06c2e5a
Autor:
Shuang-Feng Xu, Yan-Hui Zhang, Shan Wang, Zhong-Qiu Pang, Yong-Gang Fan, Jia-Yi Li, Zhan-You Wang, Chuang Guo
Publikováno v:
Redox Biology, Vol 21, Iss , Pp - (2019)
Brain iron accumulation is common in patients with Parkinson's disease (PD). Iron chelators have been investigated for their ability to prevent neurodegenerative diseases with features of iron overload. Given the non-trivial side effects of classical
Externí odkaz:
https://doaj.org/article/d4a9127579734c6a972b4417b26be04b
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
As people age, iron deposits in different areas of the brain may impair normal cognitive function and behavior. Abnormal iron metabolism generates hydroxyl radicals through the Fenton reaction, triggers oxidative stress reactions, damages cell lipids
Externí odkaz:
https://doaj.org/article/f77b5983549944178e90cb6aa018f650
Autor:
Lin-Bo Li, Rui Chai, Shuai Zhang, Shuang-Feng Xu, Yan-Hui Zhang, Hai-Long Li, Yong-Gang Fan, Chuang Guo
Publikováno v:
Cells, Vol 8, Iss 2, p 198 (2019)
Although the causal relationship between Alzheimer’s disease (AD) and iron overload remains unclear, iron dyshomeostasis or improper transport mechanisms are speculated to lead to the accumulation of this neurotoxic metal in the hippocampal formati
Externí odkaz:
https://doaj.org/article/f68b57d32c234b48b143fc734d9e5c82
Autor:
Ling-Xiao Zhao, Zhi-Qiang Gong, Qi Zhang, Da-Long He, Ri-Le Ge, Jin Meng, Hang Ren, Yong-Gang Fan, Zhan-You Wang
Publikováno v:
Journal of Controlled Release. 359:12-25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e852bd9651060446a41737b588a0562d
https://doi.org/10.1016/j.jconrel.2023.05.035
https://doi.org/10.1016/j.jconrel.2023.05.035