Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Yong-Chuan Zhu"'
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113202- (2023)
Summary: CDKL5 deficiency disorder (CDD) is a severe epileptic encephalopathy resulting from pathological mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene. Despite significant progress in understanding the neuronal function of CD
Externí odkaz:
https://doaj.org/article/a7da276a6a804eaf86cd6798b566f76e
Autor:
Wenhua Li, Aiyu Yao, Hui Zhi, Kuldeep Kaur, Yong-Chuan Zhu, Mingyue Jia, Hui Zhao, Qifu Wang, Shan Jin, Guoli Zhao, Zhi-Qi Xiong, Yong Q Zhang
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006062 (2016)
Altered expression of the E3 ubiquitin ligase UBE3A, which is involved in protein degradation through the proteasome-mediated pathway, is associated with neurodevelopmental and behavioral defects observed in Angelman syndrome (AS) and autism. However
Externí odkaz:
https://doaj.org/article/d73f7d6b40e84c45a4489a537ccc2a85
Autor:
Min Huang, Eric A. Bushong, Sebastien Phan, Daniel Boemer, Anton Maximov, Yong-Chuan Zhu, Mark H. Ellisman, Kristin Tsui, Elizabeth Beutter, Marco Uytiepo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The formation of new memories requires transcription. However, the mechanisms that limit signaling of relevant gene programs in space and time for precision of information coding remain poorly understood. We found that, during learning, the cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a503cd82588babb55d7b9b4ac9fd8dcf
http://link.springer.com/article/10.1038/s41467-019-11409-0
http://link.springer.com/article/10.1038/s41467-019-11409-0
Autor:
Marco Uytiepo, Matthias G. Haberl, Frederieke Scheiwe, Eric A. Bushong, Weiheng Zhang, Yong-Chuan Zhu, Anton Maximov, Danielle Luu, Brandon Chui, Elizabeth Beutter, Mark H. Ellisman, Lyanne Chang
Publikováno v:
Cell reports
Cell Reports, Vol 35, Iss 1, Pp 108953-(2021)
Cell Reports, Vol 35, Iss 1, Pp 108953-(2021)
SUMMARY Chemical synapses of shared cellular origins have remarkably heterogeneous structures, but how this diversity is generated is unclear. Here, we use three-dimensional (3D) electron microscopy and artificial intelligence algorithms for image pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8fc9553ae3530c1df41672b98569e3
https://pubmed.ncbi.nlm.nih.gov/33826888
https://pubmed.ncbi.nlm.nih.gov/33826888
Autor:
Yong-Chuan Zhu, Zhi-Qi Xiong
Publikováno v:
Developmental Neurobiology. 79:8-19
The X-linked gene cyclin-dependent kinase-like 5 (CDKL5) encodes a serine/threonine kinase abundantly expressed in the brain. Mutations in CDKL5 have been associated with neurodevelopmental disorders characterized by early-onset epileptic encephalopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bea9799e02f87891f70c3818aab6afe
https://doi.org/10.1002/dneu.22639
https://doi.org/10.1002/dneu.22639
Publikováno v:
Journal of Neurochemistry. 138:60-73
At nerve terminals, endocytosis efficiently recycles vesicle membrane to maintain synaptic transmission under different levels of neuronal activity. Ca(2+) and its downstream signal pathways are critical for the activity-dependent regulation of endoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae533407052643639c15f72145c7b4c
https://doi.org/10.1111/jnc.13635
https://doi.org/10.1111/jnc.13635
Publikováno v:
Proceedings of the National Academy of Sciences. 110:9118-9123
The X-linked gene cyclin-dependent kinase-like 5 ( CDKL5 ) is mutated in severe neurodevelopmental disorders, including some forms of atypical Rett syndrome, but the function and regulation of CDKL5 protein in neurons remain to be elucidated. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aff03efe4bebf1ff5955be5a8bf0668
https://doi.org/10.1073/pnas.1300003110
https://doi.org/10.1073/pnas.1300003110
Autor:
Jing Zheng, Jiong Tao, Jing Yu, Dan Li, Yong-Chuan Zhu, Sheng Miao, Qian Chen, Li Xu, Zhi-Qi Xiong, Yang Zhou, Chi Zhang
Publikováno v:
The Journal of Neuroscience. 30:12777-12786
Mutations in cyclin-dependent kinase-like 5 (CDKL5), also known as serine/threonine kinase 9 (STK9), have been identified in patients with Rett syndrome (RTT) and X-linked infantile spasm. However, the function of CDKL5 in the brain remains unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f4c04029ce8ad2b7809dee8583c66d
https://doi.org/10.1523/jneurosci.1102-10.2010
https://doi.org/10.1523/jneurosci.1102-10.2010
Autor:
Zhi-Qi Xiong, Yong Q. Zhang, Guoli Zhao, Mingyue Jia, Aiyu Yao, Wenhua Li, Hui Zhi, Shan Jin, Kuldeep Kaur, Qifu Wang, Hui Zhao, Yong-Chuan Zhu
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 5, p e1006062 (2016)
PLoS Genetics, Vol 12, Iss 5, p e1006062 (2016)
Altered expression of the E3 ubiquitin ligase UBE3A, which is involved in protein degradation through the proteasome-mediated pathway, is associated with neurodevelopmental and behavioral defects observed in Angelman syndrome (AS) and autism. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a330d3422a67f6320f86052722e5c1a1
https://pubmed.ncbi.nlm.nih.gov/27232889
https://pubmed.ncbi.nlm.nih.gov/27232889
Autor:
Min Huang, Suyeon Ju, Mark H. Ellisman, Anton Maximov, Eric A. Bushong, Camille Considine, Marco Uytiepo, Sebastien Phan, Richard Sando, Yong-Chuan Zhu
Publikováno v:
Neuron. 94:312-321.e3
Synaptic excitation mediates a broad spectrum of structural changes in neural circuits across the brain. Here, we examine the morphologies, wiring, and architectures of single synapses of projection neurons in the murine hippocampus that developed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bde30e70b57b95618aaf916e10dfd0
https://doi.org/10.1016/j.neuron.2017.03.047
https://doi.org/10.1016/j.neuron.2017.03.047