Zobrazeno 1 - 10
of 903
pro vyhledávání: '"Yong Y. Lin"'
Publikováno v:
Chest. 153:792-798
Insights into the clinical course of COPD indicate the need for new therapies for this condition. The discovery of alpha-1 antitrypsin deficiency (AATD) led to the protease-antiprotease imbalance hypothesis, which was applied to COPD related to AATD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e553299f2f8cee27a5c4350a1711c5
https://doi.org/10.1016/j.chest.2017.12.016
https://doi.org/10.1016/j.chest.2017.12.016
Publikováno v:
Tetrahedron. 73:3838-3847
Elastin is a vital extracellular matrix protein, which is known for providing elasticity in numerous tissues. It is formed by the self-assembly and subsequent crosslinking of elastin precursor, tropoelastin. Two tetrafunctional, pyridinium-based amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::157e79632b2ed85d56969c71115c4686
https://doi.org/10.1016/j.tet.2017.05.045
https://doi.org/10.1016/j.tet.2017.05.045
Publikováno v:
Annals of the American Thoracic Society. 13:S336-S340
Biomarkers of pathogenesis in chronic obstructive pulmonary disease (COPD) can significantly accelerate drug development. In COPD related to alpha-1 antitrypsin deficiency, the role of neutrophil elastase and its inhibition by alpha-1 antitrypsin pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a4f0115aae08a9f42cf2b46eee3356
https://doi.org/10.1513/annalsats.201509-574kv
https://doi.org/10.1513/annalsats.201509-574kv
Autor:
Haruka Yamada, Toyonobu Usuki, Yoshiro Masuyama, Rina Suzuki, Noriyuki Suzuki, Takanori Sugimura, Yohei Koseki, Yong Y. Lin, Keita Ogawa
Publikováno v:
European Journal of Organic Chemistry. 2015:4024-4032
Isodesmosine is a crosslinking pyridinium amino acid of elastin and is an attractive biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD). In this paper, we describe the total synthesis of isodesmosine. The key features of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0295af6a8a131319421a4e5250bddc82
https://doi.org/10.1002/ejoc.201500449
https://doi.org/10.1002/ejoc.201500449
Autor:
Robert A. Sandhaus, Shuren Ma, Jerome O. Cantor, Gerard M. Turino, Jonathan M. Edelman, Michael Fries, Yong Y. Lin, Kenneth R. Chapman, N. Gerard McElvaney
Publikováno v:
Chronic obstructive pulmonary diseases (Miami, Fla.). 4(1)
The RAPID (NCT00261833; N=180) and RAPID Extension (NCT00670007; N=140) trials demonstrated significantly reduced lung density decline in patients with alpha-1 antitrypsin deficiency (AATD) receiving alpha-1 proteinase inhibitor (A1PI) versus placebo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9d727b8929cd06970f1c40dca399cf
https://pubmed.ncbi.nlm.nih.gov/28848909
https://pubmed.ncbi.nlm.nih.gov/28848909
Autor:
Ruth Minkin, Shuren Ma, Lori Tartell, Edward Eden, Gerard M. Turino, Gagangeet Sandhu, Horiana Grosu, Yong Y. Lin
Publikováno v:
American journal of therapeutics. 24(4)
Delayed diagnosis is common in patients with pulmonary arterial hypertension (PAH). Right-sided heart catheterization, the gold standard for diagnosis, is invasive and cannot be applied for routine screening. Some biomarkers have been looked into; ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b3054859d6320b0d12077f376f0e3e
https://pubmed.ncbi.nlm.nih.gov/26237301
https://pubmed.ncbi.nlm.nih.gov/26237301
Publikováno v:
COPD. 10(4)
Intravenous alpha-1 antitrypsin protein (AAT) augmentation is a prescribed therapy for severe, genetically determined, alpha-1 antitrypsin deficiency (AATD), a genetic basis for pulmonary emphysema. AAT, a predominant systemic inhibitor of neutrophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed99c59da29677e61828a3817217d7b
https://pubmed.ncbi.nlm.nih.gov/23560990
https://pubmed.ncbi.nlm.nih.gov/23560990
Stable deuterium internal standard for the isotope-dilution LC-MS/MS analysis of elastin degradation
Publikováno v:
Analytical biochemistry. 440(2)
Chemical synthesis of the deuterium isotope desmosine-d4 has been achieved. This isotopic compound possesses all four deuterium atoms at the alkanyl carbons of the alkyl amino acid substitution in the desmosine molecule and is stable toward acid hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6af1baa4a6d269ea8263260ebee379
https://pubmed.ncbi.nlm.nih.gov/23727558
https://pubmed.ncbi.nlm.nih.gov/23727558
Autor:
Yong Y. Lin, Anup K. Ray, Zhen-Jia Chen, Robert A. Moreau, William F. Fett, Ruth E. Stark, Stanley F. Osman, H. C. Gerard
Publikováno v:
Phytochemistry. 38:1361-1369
A recently developed HPLC technique has been used to identify 10 major monomers from potassium hydroxide hydrolysis and transesterification of lime cutin, revealing 16-hydroxy-10-oxo-hexadecanoic and 10,16-dihydroxyhexadecanoic acids as the major con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d6d70263af104f0a3200d501327829a
https://doi.org/10.1016/0031-9422(94)00627-6
https://doi.org/10.1016/0031-9422(94)00627-6
Publikováno v:
Proceedings of the National Academy of Sciences. 100:12941-12943
Desmosine (D) and isodesmosine (I), the intramolecular crosslinking amino acids that occur in chains of elastin, have now been found in free form in human urine. Until now, these amino acids ( M r = 526) were found to occur in urine only as higher mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d14f58a64ff086f4fd0c2bec9d47cf2
https://doi.org/10.1073/pnas.2235344100
https://doi.org/10.1073/pnas.2235344100