Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Yong Seo Cho"'
Autor:
Yu Jin Hwang, Seung Jae Hyeon, Younghee Kim, Sungsu Lim, Min Young Lee, Jieun Kim, Ashwini M. Londhe, Lizaveta Gotina, Yunha Kim, Ae Nim Pae, Yong Seo Cho, Jihye Seong, Hyemyung Seo, Yun Kyung Kim, Hyunah Choo, Hoon Ryu, Sun-Joon Min
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 856-868 (2021)
The present study describes evaluation of epigenetic regulation by a small molecule as the therapeutic potential for treatment of Huntington’s disease (HD). We identified 5-allyloxy-2-(pyrrolidin-1-yl)quinoline (APQ) as a novel SETDB1/ESET inhibito
Externí odkaz:
https://doaj.org/article/53eb5263e2d44245a87e4c6d821bd071
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 7, Pp o485-o486 (2015)
In the title compound, C17H17NO4, the cylohexane-1,3-dione ring adopts an envelope conformation with the dimethyl-subsituted C atom as the flap. Its mean plane is inclined to the benzene ring by 7.99 (19)°. The molecule has a trans conformation abou
Externí odkaz:
https://doaj.org/article/0b201c12fb7b4d3eba17cd2f040ac21a
Autor:
Juhyeon Kim, Hanbyeol Jo, Hyunseung Lee, Hyunah Choo, Hak Joong Kim, Ae Nim Pae, Yong Seo Cho, Sun-Joon Min
Publikováno v:
Molecules, Vol 22, Iss 9, p 1416 (2017)
A series of pyrimidine derivatives 4a–i were synthesized and evaluated for their binding affinities towards 5-HT2C receptors. With regard to designed molecules 4a–i, the influence of the size of alkyl ether and the absolute configuration of a ste
Externí odkaz:
https://doaj.org/article/61a418fa2f6449e19d0f7ba443c22919
Publikováno v:
Acta Crystallographica Section E, Vol 70, Iss 11, Pp o1174-o1174 (2014)
In the title compound, C20H17NO, the dihedral angle between the mean planes of the 4-methoxyphenyl ring and the naphthalene ring is 69.50 (7)°. The methoxy group is almost coplanar with the benzene ring to which it is connected [Cb—Cb—Om—Cm to
Externí odkaz:
https://doaj.org/article/5cfaad47ac8e44fd83b875395b53fe7c
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 10, Pp o1542-o1542 (2013)
In the title compound, C25H27ClO3, each of the cyclohexenone rings adopts an envelope conformation, whereas the six-membered pyran ring adopts a flattened boat conformation, with the O and methine C atoms deviating from the plane of the other four at
Externí odkaz:
https://doaj.org/article/df1f235086624c449718015ac1223127
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 8, Pp o1347-o1347 (2013)
The title compound, C25H29ClO4, adopts a trans conformation about the C=C double bond and the dimethylcyclohexenone rings both show an envelope conformation with the dimethyl-substituted C atom as the flap. In the molecule, the hydroxy and carbonyl g
Externí odkaz:
https://doaj.org/article/43a16ae57695415590c1543b8b4020a4
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 7, Pp o1025-o1025 (2013)
The title compound, C25H19N, adopts an E conformation about the C=N bond. The naphthalene ring system and the phenyl rings form dihedral angles 38.1 (1), 46.9 (8) and 48.5 (1)°, respectively, with the mean plane of the central enimino fragment. The
Externí odkaz:
https://doaj.org/article/a42ce3c9c1494af5917576390b1a4f67
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 6, Pp o985-o985 (2013)
In the title compound, C25H27FO3, each of the cyclohexenone rings adopts a half-chair conformation, whereas the six-membered pyran ring adopts a flattened boat conformation, with the O and methine C atoms deviating by 0.0769 (15) and 0.196 (2) Å, re
Externí odkaz:
https://doaj.org/article/ca30bb75563548d584d79beee07cd48b
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 4, Pp o548-o548 (2013)
In the title compound, C19H14N2O2, the dihedral angle between the mean planes of the 4-nitrophenyl ring and the naphthalene ring system is 12.79 (2)°. The imine group displays a C—C—N=C torsion angle of 41.0 (2)° and the C=N group has an E conf
Externí odkaz:
https://doaj.org/article/f17fb7ed9ecc440fb2d2dbe7cc96acae
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 3, Pp o397-o397 (2013)
In the title compound, C25H29FO4, each cyclohexenone ring has an envelope conformation with the dimethyl-substituted atom as the flap. The hydroxy and carbonyl groups form two intramolecular O—H...O hydrogen bonds, as is typical for xanthene deriva
Externí odkaz:
https://doaj.org/article/db48b77f45ff48889a005cda0b419ef0