Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Yong Q Chen"'
Autor:
Rong Wang, Yuanyuan Mi, Jiang Ni, Yang Wang, Lingwen Ding, Xuebin Ran, Qiaoyang Sun, Soo Yong Tan, H Phillip Koeffler, Ninghan Feng, Yong Q Chen
Publikováno v:
Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)
Abstract Treatment of castration‐resistant prostate cancer (CRPC) is a long‐standing clinical challenge. Traditionally, CRPC drugs work by either reducing dihydrotestosterone biosynthesis or blocking androgen receptor (AR) signaling. Here it is d
Externí odkaz:
https://doaj.org/article/598b79c327864817bc781b8e5e7ce0ef
Autor:
Xiaoying Wang, Bingqian Sun, Lengyun Wei, Xiao Jian, Kai Shan, Qingwen He, Fengjiao Huang, Xiaosong Ge, Xiang Gao, Ninghan Feng, Yong Q Chen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 2, Pp 86-97 (2022)
The excessive accumulation of saturated fatty acids and cholesterol have been linked to prostate cancer (Pca). Here, we found that lipoproteins, apolipoproteins, triglycerides and free fatty acids are significantly higher in the peripheral blood of p
Externí odkaz:
https://doaj.org/article/350149bbefb648e1a7d5b71361041d50
Publikováno v:
Adipocyte, Vol 10, Iss 1, Pp 646-657 (2021)
Obesity and associated complications are becoming a pandemic. Inhibiting adipogenesis is an important intervention for the treatment of obesity. Despite intensive investigations, numerous mechanistic aspects of adipogenesis remain unclear, and many p
Externí odkaz:
https://doaj.org/article/27511d5f6f60430598d7247d000273d7
Autor:
Shenglong Zhu, Ninghan Feng, Guangxiao Lin, Yuelin Tong, Xuan Jiang, Qin Yang, Shunhe Wang, Wei Chen, Zhao He, Yong Q Chen
Publikováno v:
Cellular Physiology and Biochemistry, Vol 48, Iss 6, Pp 2318-2336 (2018)
Background/Aims: Rapamycin (Rp), the main mammalian target of rapamycin complex inhibitor, is a promising therapeutic agent for breast cancer. However, metabolic disorders and drug resistance reduce its efficacy. Epidemiological, clinical, and experi
Externí odkaz:
https://doaj.org/article/ab20c03d0b6641b783eae550162ed0f7
Autor:
Lingling Jia, Dongyao Li, Ninghan Feng, Muhammad Shamoon, Zhenghua Sun, Lei Ding, Hao Zhang, Wei Chen, Jia Sun, Yong Q Chen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Patients with type 2 diabetes (T2D) have decreased butyrate-producing bacteria. We hypothesized that supplementation with butyrate-producing bacteria may exert beneficial effects on T2D. The current study investigated the effects of well-cha
Externí odkaz:
https://doaj.org/article/307d3e58f5bf4547ae517a56c4b97278
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154373 (2016)
Obesity is associated with a cluster of metabolic disorders and systemic low-grade inflammation involving multiple organs. Recent findings have suggested that intestine is a key organ altered in response to high fat diet (HFD) feeding. Probiotics mai
Externí odkaz:
https://doaj.org/article/c86c114349054b35aebdca1f97de8449
Autor:
Jiali Xing, Gang Wang, Qiuxiang Zhang, Xiaoming Liu, Zhennan Gu, Hao Zhang, Yong Q Chen, Wei Chen
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119058 (2015)
Antioxidant activity of lactic acid bacteria is associated with multiple health-protective effects. Traditional indexes of chemical antioxidant activities poorly reflect the antioxidant effects of these bacteria in vivo. Cellular antioxidant activity
Externí odkaz:
https://doaj.org/article/083933830679496e84c6988efe2517d8
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128396 (2015)
The oleaginous fungus, Mucor circinelloides, is one of few fungi that produce high amounts of γ-linolenic acid (GLA); however, it usually only produces
Externí odkaz:
https://doaj.org/article/2e78dfb7692a4f42bf1d39985382a796
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137543 (2015)
The genome of a high lipid-producing fungus Mucor circinelloides WJ11 (36% w/w lipid, cell dry weight, CDW) was sequenced and compared with that of the low lipid-producing strain, CBS 277.49 (15% w/w lipid, CDW), which had been sequenced by Joint Gen
Externí odkaz:
https://doaj.org/article/f584327d27584b54bed4dddf580a8e9d
Autor:
Chunqing Ai, Qiuxiang Zhang, Chengcheng Ren, Gang Wang, Xiaoming Liu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Yong Q Chen, Wei Chen
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109461 (2014)
Mucosal vaccine based on lactic acid bacteria is an attractive concept for the prevention and treatment of allergic diseases, but their mechanisms of action in vivo are poorly understood. Therefore, we sought to investigate how recombinant major dust
Externí odkaz:
https://doaj.org/article/088005e03de1428f8e0e0751ec66822e