Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Yong Mi Choi"'
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
Autor:
Yong Mi Choi, Dalila Ajjaji, Kaelin D. Fleming, Peter P. Borbat, Meredith L. Jenkins, Brandon E. Moeller, Shaveen Fernando, Surita R. Bhatia, Jack H. Freed, John E. Burke, Abdou Rachid Thiam, Michael V. Airola
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated proteins called perilipins (PLINs). During LD biogenesis, perilipin
Externí odkaz:
https://doaj.org/article/88d19ef3aa294ad58ab797d027080ed5
Autor:
Weijing Gu, Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang, Nimi M. Patel, Yong Mi Choi, John E. Burke, Karen Reue, Michael V. Airola
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Lipins need to bind cell membranes before they can function as phosphatidic acid phosphatases. Here, the authors elucidate the structural basis of lipin membrane-association and identify a lipin domain with a novel protein fold that is critical for m
Externí odkaz:
https://doaj.org/article/3b33c35036634db9ae0d9e4f5089b84e
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168019 (2016)
Kaposi's sarcoma-associated herpesvirus (KSHV) is a highly infectious human herpesvirus that causes Kaposi's sarcoma. KSHV encodes functional thymidylate synthase, which is a target for anticancer drugs such as raltitrexed or 5-fluorouracil. Thymidyl
Externí odkaz:
https://doaj.org/article/29ad60e3904549868284c077824e942d
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
Autor:
Yong Mi Choi, Dalila Ajjaji, Kaelin D. Fleming, Peter P. Borbat, Meredith L. Jenkins, Brandon E. Moeller, Shaveen Fernando, Surita R. Bhatia, Jack H. Freed, John E. Burke, Abdou Rachid Thiam, Michael V. Airola
Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated proteins called perilipins (PLINs). During LD biogenesis, perilipin 3 (PLIN3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ab694a4005bdbc94cab2b3f2a6bf6db
https://doi.org/10.1101/2022.11.17.516819
https://doi.org/10.1101/2022.11.17.516819
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a116fbacecc72fda3a6290606688295
https://doi.org/10.1096/fasebj.2022.36.s1.00r88
https://doi.org/10.1096/fasebj.2022.36.s1.00r88
Autor:
Nimi M. Patel, Huan Wang, Reece M. Hoffmann, Jong Won Yang, Shujuan Gao, Karen Reue, Weijing Gu, Yong Mi Choi, Kaelin D. Fleming, John E. Burke, Michael V. Airola
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Phospholipid synthesis and fat storage as triglycerides are regulated by lipin phosphatidic acid phosphatases (PAPs), whose enzymatic PAP function requires association with cellular membranes. Using hydrogen deuterium exchange mass spectrometry, we f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b3614ae3e143f70257245699b7b27b
https://escholarship.org/uc/item/5ng3377s
https://escholarship.org/uc/item/5ng3377s
Autor:
Justin Shumate, Nicolas Coant, Yuka Otsuka, Michael V. Airola, Ron Rahaim, Yong-Mi Choi, Louis Scampavia, Essa M. Saied, Yusuf A. Hannun, Justin Snider, John D. Haley, Chris P. Cariello, Christoph Arenz, Thomas D. Bannister, Timothy P. Spicer
Publikováno v:
SLAS Discov
There is interest in developing inhibitors of human neutral ceramidase (nCDase) because this enzyme plays a critical role in colon cancer. There are currently no potent or clinically effective inhibitors for nCDase reported to date, so we adapted a f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdb3fd4c933dca42371ea0fe4faa833
Publikováno v:
Analytical Biochemistry. 643:114577
Neutral ceramidase is a hydrolase of ceramide that has been implicated in multiple biologic processes, including inflammation and oncogenesis. Ceramides and other sphingolipids, belong to a family of N-acyl linked lipids that are biologically active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6acc78bf9d000112e77426bc329dfed
https://doi.org/10.1016/j.ab.2022.114577
https://doi.org/10.1016/j.ab.2022.114577
Autor:
Mark Munson, James Pribish, Lim Sungtaek, Maniar Sachin, Bradford H. Hirth, Robert H. Barker, Jiang John Z, Yong Mi Choi-Sledeski, Sukanthini Thurairatnam, Kwon Yon Musick, Elina Makino, John E. Macor
Publikováno v:
ACS Med Chem Lett
[Image: see text] Metachromatic leukodystrophy (MLD) is a rare, genetic lysosomal storage disorder caused by the deficiency of arylsulfatase A enzyme, which results in the accumulation of sulfatide in the lysosomes of the tissues of central and perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0e9cd71be8f13535f7151488851852
https://europepmc.org/articles/PMC7549271/
https://europepmc.org/articles/PMC7549271/
Autor:
Jiping Yang, Jian Shen, Winfried Heyse, Doris Andert, Harald Schweitzer, Chengyue Zhu, Gregory A. Nemeth, Yong-Mi Choi, Zhicheng Zhao, Timothy A. Ayers, Vincent Morrison, Teng-Man Chen, Norbert Nagel
Publikováno v:
Journal of Pharmaceutical Analysis
Journal of Pharmaceutical Analysis, Vol 4, Iss 3, Pp 197-204 (2014)
Journal of Pharmaceutical Analysis, Vol 4, Iss 3, Pp 197-204 (2014)
Otamixaban is a potent (Ki=0.5Â nM) fXa inhibitor currently in late-stage clinical development at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286fd0572070c3d598a63939b6535cd2