Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Yong Kook Kang"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
SETDB1 is a histone H3-lysine 9-specific methyltransferase that fulfills epigenetic functions inside the nucleus; however, when overexpressed, SETDB1 majorily localizes in the cytoplasm. SETDB1 has a single nuclear-localization-signal (NLS) motif and
Externí odkaz:
https://doaj.org/article/7d5cff63cd214fcc957eb80155dc8691
Autor:
Yong-Kook Kang, Byungkuk Min
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
An increasing volume of evidence suggests that SETDB1 plays a role in the tumorigenesis of various cancers, classifying SETDB1 as an oncoprotein. However, owing to its numerous protein partners and their global-scale effects, the molecular mechanism
Externí odkaz:
https://doaj.org/article/13dd27f49a3849fca88dd54f1a57e607
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Continued CRISPR/Cas9-mediated editing activity that allows differential and asynchronous modification of alleles in successive cell generations expands allelic complexity. To understand the earliest events during CRISPR/Cas9 editing and the allelic
Externí odkaz:
https://doaj.org/article/b1e5292d2a0d423c8fe65e2588fd37f4
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 5, Pp 1365-1371 (2016)
Epigenetic reprogramming is necessary in somatic cell nuclear transfer (SCNT) embryos in order to erase the differentiation-associated epigenetic marks of donor cells. However, such epigenetic memories often persist throughout the course of clonal de
Externí odkaz:
https://doaj.org/article/1487d8520a3246f5b6e8f019bf87bdcf
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Somatic cell nuclear transfer (scNT) embryos suffer from damage caused by micro-operation (manipulation) and inefficient genome reprograming that hinder their normal development at different levels and in distinct ways. These two effects are insepara
Externí odkaz:
https://doaj.org/article/ac5e2815750d42168f4ac68f9775ec4f
Publikováno v:
BioTechniques, Vol 59, Iss 1, Pp 34-41 (2015)
The use of secondary or reprogrammable cells in the production of induced pluripotent stem cells (iPSCs) circumvents random infection by various viral particles and random, uncontrollable integrations of the viral genomes into different genomic loci.
Externí odkaz:
https://doaj.org/article/c9367a7b428448c2bf6be5ca1e01915f
Autor:
Jeongmin Ha, Bum Suk Kim, Byungkuk Min, Juhyeon Nam, Jae-Geun Lee, Minhyung Lee, Byoung-Ha Yoon, Yoon Ha Choi, Ilkyun Im, Jung Sun Park, Hyosun Choi, Areum Baek, Sang Mi Cho, Mi-Ok Lee, Ki-Hoan Nam, Ji Young Mun, Mirang Kim, Seon-Young Kim, Mi Young Son, Yong-Kook Kang, Jeong-Soo Lee, Jong Kyoung Kim, Janghwan Kim
Publikováno v:
Science advances. 8(43)
Amphibians and fish show considerable regeneration potential via dedifferentiation of somatic cells into blastemal cells. In terms of dedifferentiation, in vitro cellular reprogramming has been proposed to share common processes with in vivo tissue r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca67d70f9f3bde6fddeb8da28bbafea
https://pubmed.ncbi.nlm.nih.gov/36306352
https://pubmed.ncbi.nlm.nih.gov/36306352
Publikováno v:
Biochemical and biophysical research communications. 637
The microRNA (miRNA) gene cluster on chromosome 19, C19MC, is the largest primate-specific miRNA gene cluster. The 46 homologous miRNA genes in C19MC are highly expressed in the placenta, but repressed in other tissues by DNA methylation. Here, we fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b15eaf5dc8f4748b00df5b95450fba7
https://pubmed.ncbi.nlm.nih.gov/36375246
https://pubmed.ncbi.nlm.nih.gov/36375246
Publikováno v:
Frontiers in Genetics, Vol 8 (2017)
Methylated-DNA sequencing technologies are producing vast amounts of methylome data from cancer samples, from which cancer-associated differentially methylated CpG sites (cDMCs) are continuously identified and filed. The inclusion of as many cDMCs as
Externí odkaz:
https://doaj.org/article/4a7f07e198de416e8f103541ac1f5635
Publikováno v:
Nucleic Acids Research
Genome-wide passive DNA demethylation in cleavage-stage mouse embryos is related to the cytoplasmic localization of the maintenance methyltransferase DNMT1. However, recent studies provided evidences of the nuclear localization of DNMT1 and its contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a0c337661fad79552682d6c3754a4e
http://europepmc.org/articles/PMC7470951
http://europepmc.org/articles/PMC7470951