Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yong‑Ke You"'
Autor:
Hai-Di Li, Yong-Ke You, Bao-Yi Shao, Wei-Feng Wu, Yi-Fan Wang, Jian-Bo Guo, Xiao-Ming Meng, Haiyong Chen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Diabetic nephropathy (DN) is the most common chronic kidney disease. Accumulation of glucose and metabolites activates resident macrophages in kidneys. Resident macrophages play diverse roles on diabetic kidney injuries by releasing cytokines/chemoki
Externí odkaz:
https://doaj.org/article/cf12e88bb9064a009efd4ab6003d2678
Autor:
Hai-Di Li, Jin-Cheng Zeng, Wei-Feng Wu, Hui Y. Lan, Yong-Ke You, Ye-Ping Ren, Hai-Yong Chen, Xiao-Ru Huang
Publikováno v:
International Journal of Biological Sciences
Introduction and Aims: Elevated plasma levels of C-reactive protein (CRP) are closely associated with progressive renal injury in patients with chronic kidney disease (CKD). Here, we tested a hypothesis that CRP may promote renal fibrosis and inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ac489a4b533b3d2eb589ac9bff0140
http://europepmc.org/articles/PMC8495386
http://europepmc.org/articles/PMC8495386
Autor:
Hui-Yao Lan, Bi-Hua Xu, Yong-Ke You, Xiao-Ru Huang, Ronald C.W. Ma, Jingyi Sheng, Qingwen Wang
Publikováno v:
Metabolism: clinical and experimental. 103
Background Transforming growth factor (TGF)-β/Smad3 signaling is highly activated in kidneys of patients with type 2 diabetic nephropathy (T2DN), however, the precise role of Smad3 in the pathogenesis of diabetic nephropathy remains unclear. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e11dffc8e965d558b64f004e4b4597
https://pubmed.ncbi.nlm.nih.gov/31734275
https://pubmed.ncbi.nlm.nih.gov/31734275
Autor:
Lixing Lao, Jiao-Jiao Zhang, Yong‐Xian Cheng, Qi Luo, Hai-Yong Chen, Yong-Ke You, Hui Y. Lan, Wei-Feng Wu, Hong‐Jian Zhu
Publikováno v:
Journal of Cellular and Molecular Medicine
Obstructive nephropathy is the end result of a variety of diseases that block drainage from the kidney(s). Transforming growth factor‐β1 (TGF‐β1)/Smad3‐driven renal fibrosis is the common pathogenesis of obstructive nephropathy. In this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8d1fc94f4c00de3d8c08b1b8b1dda4
https://pubmed.ncbi.nlm.nih.gov/31211499
https://pubmed.ncbi.nlm.nih.gov/31211499
Autor:
Yong-Ke You, Wei-Feng Wu, Xiao-Ru Huang, Hai-Di Li, Ye-Ping Ren, Jin-Cheng Zeng, Haiyong Chen, Hui Yao Lan
Publikováno v:
International Journal of Biological Sciences; 2021, Vol. 17 Issue 14, p3911-3922, 12p
Autor:
Jun Xiao, Anping Xu, Lin-Li Lv, Xiao-Ru Huang, Hui-Yao Lan, Min Feng, Si-Fan Sun, Patrick Ming-Kuen Tang, Yong-Ke You
Transforming growth factor β (TGF-β)/Smad3 signaling plays a role in tissue fibrosis. We report here that Erbb4-IR is a novel long non-coding RNA (lncRNA) responsible for TGF-β/Smad3-mediated renal fibrosis and is a specific therapeutic target for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4093abf31cefeeb04ed976b832d227
https://europepmc.org/articles/PMC5763082/
https://europepmc.org/articles/PMC5763082/
Autor:
Hai-Yong Chen, Xiang Zhong, Hui Y. Lan, Arthur Ck Chung, Xiao R. Huang, Yong-Ke You, Xiao-Ming Meng
Publikováno v:
Molecular Therapy. 22(4):842-853
Inflammation and its consequent fibrosis are two main features of diabetic nephropathy (DN), but target therapy on these processes for DN remains yet ineffective. We report here that miR-29b is a novel therapeutic agent capable of inhibiting progress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb425ac3bf3e8766b4510762180a4d2
Autor:
Le Huang, Lizhen Zheng, Dong Yao, Hui-Yao Lan, Ling Qin, Yong-Ke You, Hai-Yong Chen, Xiao-Ru Huang, Tracy Y. Zhu
Publikováno v:
Scientific Reports
This study aimed to evaluate the validation of the leptin receptor-deficient mice model for secondary osteoporosis associated with type 2 diabetes mellitus (T2DM) at bone micro-architectural level. Thirty three 36-week old male mice were divided into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b62de7b3e96c4d1f0dc9c794b68c5c
http://europepmc.org/articles/PMC4901274
http://europepmc.org/articles/PMC4901274
Publikováno v:
Scientific Reports
C-reactive protein (CRP) is associated with progressive diabetic nephropathy in patients with type-2 diabetes (T2DN). However, role of CRP in T2DN remains unclear. We report here that CRP is pathogenic in T2DN in db/db mice that express human CRP (CR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b82e3ea96cce187ef7086f1a37efe1
https://doi.org/10.1038/srep26740
https://doi.org/10.1038/srep26740
Autor:
Jun Ni, Chunjie Li, Lin-Li Lv, Hui-Yao Lan, Min Feng, Xiao-Ru Huang, Patrick Ming-Kuen Tang, Yong-Ke You, Bi-Cheng Liu, Hong Jin
Publikováno v:
Nephrology Dialysis Transplantation. 31:i143-i143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c6f1fac0acb716f6cce6812db13ce25
https://doi.org/10.1093/ndt/gfw161.01
https://doi.org/10.1093/ndt/gfw161.01