Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Yong‐Zhen Xu"'
Autor:
Chen‐Hui Li, Shao‐Bo Liang, Qi‐Wei Huang, Zhen‐Zhen Zhou, Zhan Ding, Ni Long, Kwang‐Chon Wi, Liang Li, Xi‐Ping Jiang, Yu‐Jie Fan, Yong‐Zhen Xu
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract RNA splicing is crucial in the multilayer regulatory networks for gene expression, making functional interactions with DNA‐ and other RNA‐processing machineries in the nucleus. However, these established couplings are all major spliceoso
Externí odkaz:
https://doaj.org/article/b476c78574ba4f85a96a9f552cf9944a
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1011021 (2023)
Small nuclear RNAs (snRNAs) are structural and functional cores of the spliceosome. In metazoan genomes, each snRNA has multiple copies/variants, up to hundreds in mammals. However, the expressions and functions of each copy/variant in one organism h
Externí odkaz:
https://doaj.org/article/b4d2c07364e246098940e2c44def07a3
Autor:
Liang Li, Zhan Ding, Ting-Lin Pang, Bei Zhang, Chen-Hui Li, An-Min Liang, Yu-Ru Wang, Yu Zhou, Yu-Jie Fan, Yong-Zhen Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Spinal muscular atrophy (SMA) is associated with minor splicing-related defects. Here the authors develop Drosophila models with minor spliceosomal-snRNA deletions, and demonstrate SMA-like phenotypes.
Externí odkaz:
https://doaj.org/article/d3335744b91b46fb96bb2443ca7deef2
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
SF3B1 mutations occur in many cancers, and the highly conserved His662 residue is one of the hotspot mutation sites. To address effects on splicing and development, we constructed strains carrying point mutations at the corresponding residue His698 i
Externí odkaz:
https://doaj.org/article/98c740931fee44b8b4d3bd83c8718996
Autor:
Ting-Lin Pang, Zhan Ding, Shao-Bo Liang, Liang Li, Bei Zhang, Yu Zhang, Yu-Jie Fan, Yong-Zhen Xu
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Interrupted exons in the pre-mRNA transcripts are ligated together through RNA splicing, which plays a critical role in the regulation of gene expression. Exons with a length ≤ 30 nt are defined as microexons that are unique in identification. Howe
Externí odkaz:
https://doaj.org/article/89426ea8f54e427abf7f4116080f9978
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009098 (2020)
The 2,2,7-trimethylguanosine (TMG) cap is one of the first identified modifications on eukaryotic RNAs. TMG, synthesized by the conserved Tgs1 enzyme, is abundantly present on snRNAs essential for pre-mRNA splicing. Results from ex vivo experiments i
Externí odkaz:
https://doaj.org/article/22ed57e4891c4604bd0f2cf5b597a6ff
Autor:
Yu-Jie Fan, Zhan Ding, Yu Zhang, Ruibao Su, Jia-Le Yue, An-Min Liang, Qi-Wei Huang, Yan-Ran Meng, Muwang Li, Yuanchao Xue, Yong-Zhen Xu
Publikováno v:
Nucleic Acids Research.
Conversely to canonical splicing, back-splicing connects the upstream 3' splice site (SS) with a downstream 5'SS and generates exonic circular RNAs (circRNAs) that are widely identified and have regulatory functions in eukaryotic gene expression. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84cab6ef20b6502d2b790ddef69dcbc4
https://doi.org/10.1093/nar/gkad280
https://doi.org/10.1093/nar/gkad280
Publikováno v:
WIREs RNA. 14
Catalyzed by spliceosomes in the nucleus, RNA splicing removes intronic sequences from precursor RNAs in eukaryotes to generate mature RNA, which also significantly increases proteome complexity and fine-tunes gene expression. Most metazoans have two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553bdcb14620f028b2d4d35b72b51bf4
https://doi.org/10.1002/wrna.1761
https://doi.org/10.1002/wrna.1761
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1269-1278 (2013)
The DEAD-box adenosine triphosphatase (ATPase) Prp5p facilitates U2 small nuclear ribonucleoprotein particle (snRNP) binding to the intron branch site region during spliceosome assembly. We present crystal structures of S. cerevisiae Prp5p alone and
Externí odkaz:
https://doaj.org/article/ea7da6505e2044fd8c37291485bc6660
Autor:
Charles C. Query, Jia Pu, Zhan Ding, Wei Shao, Yu Xian Shen, Yong-Zhen Xu, Zeng Zhang Zheng, Ji Jia Shen, Yu Jie Fan
Publikováno v:
Nucleic Acids Research
Transcription and pre-mRNA splicing are coupled to promote gene expression and regulation. However, mechanisms by which transcription and splicing influence each other are still under investigation. The ATPase Prp5p is required for pre-spliceosome as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d92b1aaa2040908661c43a19526bc3
http://europepmc.org/articles/PMC7293005
http://europepmc.org/articles/PMC7293005