Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Yong‐Yu Liu"'
Autor:
Si-Yang Liu, Hua Bao, Qun Wang, Wei-Min Mao, Yedan Chen, Xiaoling Tong, Song-Tao Xu, Lin Wu, Yu-Cheng Wei, Yong-Yu Liu, Chun Chen, Ying Cheng, Rong Yin, Fan Yang, Sheng-Xiang Ren, Xiao-Fei Li, Jian Li, Cheng Huang, Zhi-Dong Liu, Shun Xu, Ke-Neng Chen, Shi-Dong Xu, Lun-Xu Liu, Ping Yu, Bu-Hai Wang, Hai-Tao Ma, Hong-Hong Yan, Song Dong, Xu-Chao Zhang, Jian Su, Jin-Ji Yang, Xue-Ning Yang, Qing Zhou, Xue Wu, Yang Shao, Wen-Zhao Zhong, Yi-Long Wu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Adjuvant gefitinib improves outcomes in non-small cell lung cancer (NSCLC) patients compared to chemotherapy, but not in all cases. Here, the authors find genomic biomarkers of response to gefitinib in NSCLC patients from the ADJUVANT trial, and prop
Externí odkaz:
https://doaj.org/article/c64a379b331b42709e78b568f7636af6
Autor:
Ronald A. Hill, Yong‐Yu Liu
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 5, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/7ea462b0c15c428cb90abc53b3721c28
Autor:
Kartik R. Roy, Mohammad B. Uddin, Sagor C. Roy, Ronald A. Hill, John Marshall, Yu‐Teh Li, Jean Christopher Chamcheu, Hua Lu, Yong‐Yu Liu
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 11, Pp 653-667 (2020)
Abstract Glucosylceramide synthase (GCS) is a key enzyme catalyzing ceramide glycosylation to generate glucosylceramide (GlcCer), which in turn serves as the precursor for cells to produce glycosphingolipids (GSLs). In cell membranes, GSLs serve as e
Externí odkaz:
https://doaj.org/article/973d41d7eb66424a8dba340670718eb5
Autor:
Xue-Ning Yang, MD, Hong-Hong Yan, MSc, Jun Wang, MD, Xiang-Yang Chu, MD, Zhi-Dong Liu, MD, Yi Shen, MD, Hai-Tao Ma, MD, Xiang-Ning Fu, MD, Jian Hu, MD, Nai-Kang Zhou, MD, Yong-Yu Liu, MD, Xin-Ming Zhou, MD, Jing-Song Li, MD, Kang Yang, MD, Jian Li, MD, Lin Xu, MD, Si-Yu Wang, MD, Qun Wang, MD, Lun-Xu Liu, MD, Shun Xu, MD, Zhong-Yuan Chen, MD, Hong-He Lou, MD, Chang-Li Wang, MD, Ying Cheng, MD, Si-Yang Liu, MD, Xu-Chao Zhang, MD, Wen-Zhao Zhong, MD, Yi-Long Wu, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 3, Iss 1, Pp 100257- (2022)
Introduction: The adjuvant treatment of patients with resected lung adenocarcinoma (LUAD) remains unstandardized. We analyzed the survival outcomes of these patients based on EGFR mutation status and adjuvant chemotherapy treatment. Methods: This non
Externí odkaz:
https://doaj.org/article/8b930ddc7d7d44b482cd2a689f7ea99e
Autor:
Sachin K. Khiste, Salman B. Hosain, Yixuan Dong, Mohammad B. Uddin, Kartik R. Roy, Ronald A. Hill, Zhijun Liu, Yong-Yu Liu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Glucosylceramide synthase (GCS) is a rate-limiting enzyme catalyzing ceramide glycosylation, thereby regulating cellular ceramide levels and the synthesis of glycosphingolipids (GSLs) in cellular membranes. Alterations of GCS not only affect
Externí odkaz:
https://doaj.org/article/524f0c7128c14f34911c53c9faa60238
Publikováno v:
Bio-Protocol, Vol 9, Iss 12 (2019)
Almost all functions of cells or organs rely on the activities of cellular enzymes. Indeed, the in-vivo activities that directly represent the cellular effects of enzymes in live organs are critical importance to appreciate the roles enzymes play in
Externí odkaz:
https://doaj.org/article/e7a232b01223420489099f6daae9b1db
Autor:
Jean Christopher Chamcheu, Tithi Roy, Mohammad Burhan Uddin, Sergette Banang-Mbeumi, Roxane-Cherille N. Chamcheu, Anthony L. Walker, Yong-Yu Liu, Shile Huang
Publikováno v:
Cells, Vol 8, Iss 8, p 803 (2019)
The mammalian or mechanistic target of rapamycin (mTOR) and associated phosphatidyl-inositiol 3-kinase (PI3K)/protein kinase B (Akt) pathways regulate cell growth, differentiation, migration, and survival, as well as angiogenesis and metabolism. Dysr
Externí odkaz:
https://doaj.org/article/697126a04e0b4597a8b28cc9d83d2666
Autor:
Vineet Gupta, Gauri A. Patwardhan, Qian-Jin Zhang, Myles C. Cabot, S. Michal Jazwinski, Yong-Yu Liu
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 866-874 (2010)
Glucosylceramide synthase (GCS or GlcT-1), converting ceramide to glucosylceramide, is a key enzyme for the synthesis of glycosphingolipids. Due to its diverse roles in physiology and diseases, GCS may be a disease marker and drug target. Current ass
Externí odkaz:
https://doaj.org/article/812d626a0b264d4d9d7325fb5c513146
Autor:
Yong-Yu Liu, Tie Yan Han, Jing Yuan Yu, Arie Bitterman, Ahn Le, Armando E. Giuliano, Myles C. Cabot
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 5, Pp 933-940 (2004)
High glucosylceramide synthase (GCS) activity is one factor contributing to multidrug resistance (MDR) in breast cancer. Enforced GCS overexpression has been shown to disrupt ceramide-induced apoptosis and to confer resistance to doxorubicin. To exam
Externí odkaz:
https://doaj.org/article/23122ba0868a4d80a9f4f8cedec65284
Autor:
Xiao-Lin Li, Marjolein Sluijter, Elien M Doorduijn, Shubha P Kale, Harris McFerrin, Yong-Yu Liu, Yan Li, Madhusoodanan Mottamal, Xin Yao, Fengkun Du, Baihan Gu, Kim Hoang, Yen H Nguyen, Nichelle Taylor, Chelsea R Stephens, Thorbald van Hall, Qian-Jin Zhang
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e108192 (2014)
The association of B7-1/CD28 between antigen presenting cells (APCs) and T-cells provides a second signal to proliferate and activate T-cell immunity at the induction phase. Many reports indicate that tumor cells transfected with B7-1 induced augment
Externí odkaz:
https://doaj.org/article/f19ef3458ca444f3bfe66781882d6c97