Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Yong‐Xiao Wang"'
Publikováno v:
Cells, Vol 13, Iss 21, p 1807 (2024)
Pulmonary artery endothelial cells (PAECs) are a major contributor to hypoxic pulmonary hypertension (PH) due to the possible roles of reactive oxygen species (ROS). However, the molecular mechanisms and functional roles of ROS in PAECs are not well
Externí odkaz:
https://doaj.org/article/396232198a3a4df3918d4fd67fa094a9
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 53 (2023)
Mitochondria are essential organelles for energy production, calcium homeostasis, redox signaling, and other cellular responses involved in pulmonary vascular biology and disease processes. Mitochondrial homeostasis depends on a balance in mitochondr
Externí odkaz:
https://doaj.org/article/b1a6b25143f74916a0763eeb22387b6e
Autor:
Lin Mei, Yun-Min Zheng, Tengyao Song, Vishal R. Yadav, Leroy C. Joseph, Lillian Truong, Sharath Kandhi, Margarida M. Barroso, Hiroshi Takeshima, Marc A. Judson, Yong-Xiao Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pulmonary hypertension is a devastating disease with elevation of pulmonary artery pressure and related to abnormal calcium signalling. Here, the authors show that suppression or stabilization of the calcium channel ryanodine receptor 2 may be a pote
Externí odkaz:
https://doaj.org/article/86bc37c2da5f4bbeb2cafd6fa120c8d0
Autor:
Linlin Zhang, Fangming Liu, Lihong Wu, Suolan Fu, Leilei Xing, Lianghui Zhang, Xiangdong Wang, Yong‐Xiao Wang
Publikováno v:
Clinical and Translational Discovery, Vol 1, Iss 1, Pp n/a-n/a (2021)
Abstract The three‐dimensional structure of chromatin is an essential part of gene expression and regulation. Modules far apart in the one‐dimensional DNA sequence can be close to each other in 3D and activated by spatially folding. Normal gene a
Externí odkaz:
https://doaj.org/article/1944bd39d00648d7abf8e3a11808fd81
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 957 (2022)
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, which is often due to pulmonary hypertension (PH). The underlying molecular mechanisms are poorly understood, and current medications are neither specific nor
Externí odkaz:
https://doaj.org/article/efdb3c31354c49cab24c15192b90b6ae
Autor:
Jorge Reyes-García, Abril Carbajal-García, Annarita Di Mise, Yun-Min Zheng, Xiangdong Wang, Yong-Xiao Wang
Publikováno v:
Antioxidants, Vol 11, Iss 3, p 473 (2022)
Mitochondria are important organelles that act as a primary site to produce reactive oxygen species (ROS). Additionally, mitochondria play a pivotal role in the regulation of Ca2+ signaling, fatty acid oxidation, and ketone synthesis. Dysfunction of
Externí odkaz:
https://doaj.org/article/c354440de7a345e89f9025bca5cee3bd
Publikováno v:
Clinical and Translational Medicine, Vol 7, Iss 1, Pp 1-9 (2018)
Abstract Background Human Yippee-like-4 (YPEL4) is a member of the YPEL gene family. This family has been characterized as the first highly conserved family of genes coding for proteins that contain putative zinc-finger-like metal-binding domains, kn
Externí odkaz:
https://doaj.org/article/b2d3f9498e074210bd49638933e97a6c
Publikováno v:
Pulmonary Circulation, Vol 8 (2018)
Externí odkaz:
https://doaj.org/article/0f308c5b7be0476e9f08868224e88899
Autor:
Ming-Yu Wei, Lu Xue, Li Tan, Wen-Bo Sai, Xiao-Cao Liu, Qiu-Ju Jiang, Jinhua Shen, Yong-Bo Peng, Ping Zhao, Meng-Fei Yu, Weiwei Chen, Li-Qun Ma, Kui Zhai, Chunbin Zou, Donglin Guo, Gangjian Qin, Yun-Min Zheng, Yong-Xiao Wang, Guangju Ji, Qing-Hua Liu
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121566 (2015)
The participation of large-conductance Ca2+ activated K+ channels (BKs) in chloroquine (chloro)-induced relaxation of precontracted airway smooth muscle (ASM) is currently undefined. In this study we found that iberiotoxin (IbTx, a selective inhibito
Externí odkaz:
https://doaj.org/article/4d1f7d8ca31a49799e71e6b5a9baa2f9
Autor:
Ting Zhang, Xiao-Jing Luo, Wen-Bo Sai, Meng-Fei Yu, Wen-Er Li, Yun-Fei Ma, Weiwei Chen, Kui Zhai, Gangjian Qin, Donglin Guo, Yun-Min Zheng, Yong-Xiao Wang, Jin-Hua Shen, Guangju Ji, Qing-Hua Liu
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101578 (2014)
Bitter tastants can induce relaxation in precontracted airway smooth muscle by activating big-conductance potassium channels (BKs) or by inactivating voltage-dependent L-type Ca2+ channels (VDLCCs). In this study, a new pathway for bitter tastant-ind
Externí odkaz:
https://doaj.org/article/351fe5a6d38c43e5850b23c94e301efb