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Publikováno v:
Cells, Vol 13, Iss 21, p 1807 (2024)
Pulmonary artery endothelial cells (PAECs) are a major contributor to hypoxic pulmonary hypertension (PH) due to the possible roles of reactive oxygen species (ROS). However, the molecular mechanisms and functional roles of ROS in PAECs are not well
Externí odkaz:
https://doaj.org/article/396232198a3a4df3918d4fd67fa094a9
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 53 (2023)
Mitochondria are essential organelles for energy production, calcium homeostasis, redox signaling, and other cellular responses involved in pulmonary vascular biology and disease processes. Mitochondrial homeostasis depends on a balance in mitochondr
Externí odkaz:
https://doaj.org/article/b1a6b25143f74916a0763eeb22387b6e
Autor:
Lin Mei, Yun-Min Zheng, Tengyao Song, Vishal R. Yadav, Leroy C. Joseph, Lillian Truong, Sharath Kandhi, Margarida M. Barroso, Hiroshi Takeshima, Marc A. Judson, Yong-Xiao Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pulmonary hypertension is a devastating disease with elevation of pulmonary artery pressure and related to abnormal calcium signalling. Here, the authors show that suppression or stabilization of the calcium channel ryanodine receptor 2 may be a pote
Externí odkaz:
https://doaj.org/article/86bc37c2da5f4bbeb2cafd6fa120c8d0
Autor:
Linlin Zhang, Fangming Liu, Lihong Wu, Suolan Fu, Leilei Xing, Lianghui Zhang, Xiangdong Wang, Yong‐Xiao Wang
Publikováno v:
Clinical and Translational Discovery, Vol 1, Iss 1, Pp n/a-n/a (2021)
Abstract The three‐dimensional structure of chromatin is an essential part of gene expression and regulation. Modules far apart in the one‐dimensional DNA sequence can be close to each other in 3D and activated by spatially folding. Normal gene a
Externí odkaz:
https://doaj.org/article/1944bd39d00648d7abf8e3a11808fd81
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 957 (2022)
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, which is often due to pulmonary hypertension (PH). The underlying molecular mechanisms are poorly understood, and current medications are neither specific nor
Externí odkaz:
https://doaj.org/article/efdb3c31354c49cab24c15192b90b6ae
Autor:
Jorge Reyes-García, Abril Carbajal-García, Annarita Di Mise, Yun-Min Zheng, Xiangdong Wang, Yong-Xiao Wang
Publikováno v:
Antioxidants, Vol 11, Iss 3, p 473 (2022)
Mitochondria are important organelles that act as a primary site to produce reactive oxygen species (ROS). Additionally, mitochondria play a pivotal role in the regulation of Ca2+ signaling, fatty acid oxidation, and ketone synthesis. Dysfunction of
Externí odkaz:
https://doaj.org/article/c354440de7a345e89f9025bca5cee3bd
Publikováno v:
Clinical and Translational Medicine, Vol 7, Iss 1, Pp 1-9 (2018)
Abstract Background Human Yippee-like-4 (YPEL4) is a member of the YPEL gene family. This family has been characterized as the first highly conserved family of genes coding for proteins that contain putative zinc-finger-like metal-binding domains, kn
Externí odkaz:
https://doaj.org/article/b2d3f9498e074210bd49638933e97a6c
Publikováno v:
Physiology. 38
Pulmonary hypertension (PH) often occurs in chronic obstructive pulmonary disease (COPD) and is the major cause of death in COPD patients. Molecular mechanisms for PH in COPD remain poorly understood, and clinical treatments are neither specific nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::160b64a4fab91778b5471e3934453d7d
https://doi.org/10.1152/physiol.2023.38.s1.5731089
https://doi.org/10.1152/physiol.2023.38.s1.5731089
Autor:
Ed Wilson Santos, Carolina Carvalho Dias, Ricardo Ambrósio Fock, Edgar Julian Pardes-Gamero, Yun-Min Zheng, Yong-Xiao Wang, Primavera Borelli
Publikováno v:
Nutrition Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16447fdd3a8f6ce0f687bf5de30b82d0
https://doi.org/10.1016/j.nutres.2023.05.006
https://doi.org/10.1016/j.nutres.2023.05.006