Zobrazeno 1 - 10
of 296
pro vyhledávání: '"Yong‐Ping Chen"'
Autor:
Jing Lin, Hong-wei Lin, Yu-xing Wang, Yan Fang, Hui-mian Jiang, Ting Li, Jia Huang, Hua-dong Zhang, Da-zhi Chen, Yong-ping Chen
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background The global prevalence of autoimmune hepatitis (AIH) is increasing due in part to the lack of effective pharmacotherapies. Growing evidence suggests that fibroblast growth factor 4 (FGF4) is crucial for diverse aspects of liver pat
Externí odkaz:
https://doaj.org/article/4e4cf849094645b3b05bf624e17a878f
Autor:
Kang‐Fu Yin, Ting Chen, Xiao‐Jing Gu, Wei‐Ming Su, Zheng Jiang, Si‐Jia Lu, Bei Cao, Li‐Yi Chi, Xia Gao, Yong‐Ping Chen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 4, Pp 1324-1334 (2024)
Abstract Background There are no effective pharmacological treatments for sarcopenia. We aim to identify potential therapeutic targets for sarcopenia by integrating various publicly available datasets. Methods We integrated druggable genome data, cis
Externí odkaz:
https://doaj.org/article/75661d3d8e1643ecb5f7344fa4a900bc
Autor:
Qing-Qing Duan, Han Wang, Wei-Ming Su, Xiao-Jing Gu, Xiao-Fei Shen, Zheng Jiang, Yan-Ling Ren, Bei Cao, Guo-Bo Li, Yi Wang, Yong-Ping Chen
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background There is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the urgent need for treatment. Methods To identify therapeutic targets
Externí odkaz:
https://doaj.org/article/bdfe3d0b6f5e4857bf7c3919efdcff64
Autor:
Kang-Fu Yin, Xiao-Jing Gu, Wei-Ming Su, Ting Chen, Jiang Long, Li Gong, Zhi-Ye Ying, Meng Dou, Zheng Jiang, Qing-Qing Duan, Bei Cao, Xia Gao, Li-Yi Chi, Yong-Ping Chen
Publikováno v:
Heliyon, Vol 10, Iss 8, Pp e27422- (2024)
Background: Recent genetic evidence supports that circulating biochemical and metabolic traits (BMTs) play a causal role in Alzheimer's disease (AD), which might be mediated by changes in brain structure. Here, we leveraged publicly available genome-
Externí odkaz:
https://doaj.org/article/3b7f8f1dd1854d2192a6f50b1b9a1475
Autor:
Xiao-Jing Gu, Wei-Ming Su, Meng Dou, Zheng Jiang, Qing-Qing Duan, Kang-Fu Yin, Bei Cao, Yi Wang, Guo-Bo Li, Yong-Ping Chen
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Genome‑wide association studies (GWASs) have revealed numerous loci associated with Parkinson’s disease (PD). However, some potential causal/risk genes were still not revealed and no etiological therapies are available. To find potential
Externí odkaz:
https://doaj.org/article/44610c7bed4e4464b0c13c8a59398f99
Publikováno v:
Water Science and Engineering, Vol 16, Iss 1, Pp 83-93 (2023)
Due to the difference in density between the discharge effluent and coastal water, partially treated wastewater is often discharged into the marine environment as a buoyant jet via submarine outfalls with multiport diffusers. The dilution characteris
Externí odkaz:
https://doaj.org/article/9987190f838945ffa32463ca1b75b468
Autor:
Yong‐Ping Chen, Yuxiang Liao, Li Yuan, Xiao‐Kai Huang, Ji‐Chen Ruan, Hui‐Ran Lin, Lei Miao, Zhen‐Jian Zhuo
Publikováno v:
Cancer Innovation, Vol 1, Iss 1, Pp 70-79 (2022)
Abstract Background Glioma is one of the central nervous system (CNS) tumors in children, accounting for 80% of malignant brain tumors. Nucleotide excision repair (NER) is a vital pathway during DNA damage repair progression. Xeroderma pigmentosum gr
Externí odkaz:
https://doaj.org/article/0f6f1b1a44b84b058824faa7a1ae04f8
Autor:
Wei-Ming Su, Xiao-Jing Gu, Qing-Qing Duan, Zheng Jiang, Xia Gao, Hui-Fang Shang, Yong-Ping Chen
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background The time of survival in patients with amyotrophic lateral sclerosis (ALS) varies greatly, and the genetic factors that contribute to the survival of ALS are not well studied. There is a lack of a comprehensive study to elucidate t
Externí odkaz:
https://doaj.org/article/776eff90d88b4e19b037e31f0c074cb1
Autor:
Qing-Qing Duan, Zheng Jiang, Wei-Ming Su, Xiao-Jing Gu, Han Wang, Yang-Fan Cheng, Bei Cao, Xia Gao, Yi Wang, Yong-Ping Chen
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
BackgroundThe etiology of amyotrophic lateral sclerosis (ALS) remains largely unknown. This study aimed to summarize the relationship between ALS and its genetic and non-genetic risk factors.MethodA search of relevant literature from PubMed, Embase,
Externí odkaz:
https://doaj.org/article/8a80bd0baeec453c955399117598fe00
Autor:
Qian-Qian Wei, Yan-Bing Hou, Ling-Yu Zhang, Ru-Wei Ou, Bei Cao, Yong-Ping Chen, Hui-Fang Shang
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 4, Pp 875-880 (2022)
The neutrophil-to-lymphocyte ratio (NLR) is considered a robust prognostic biomarker for predicting patient survival outcomes in many diseases. However, it remains unclear whether it can be used as a biomarker for amyotrophic lateral sclerosis (ALS).
Externí odkaz:
https://doaj.org/article/46fb561e3d334e3a8f3c47c0c0aaeb45