Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Yong‐Li Zhong"'
Autor:
Kaori Hiraga, Tetsuji Itoh, Deeptak Verma, Wei Wang, Chen Huang, Michael Ardolino, Yong‐Li Zhong, Grant Murphy
Publikováno v:
ChemCatChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e02a0011e12c95c57eec24792f30c32b
https://doi.org/10.1002/cctc.202300238
https://doi.org/10.1002/cctc.202300238
Autor:
Yong-Li Zhong, C. Scott Shultz, Jacob M. Janey, Yonggang Chen, Birgit Kosjek, Lushi Tan, Jeffrey C. Moore, Michael Shevlin
Publikováno v:
The Journal of Organic Chemistry. 87:2120-2128
Two scalable and efficient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed from a simple pyridine building block. The key step to set the stereochemistry relied on either chiral rhodium catalyst-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4280b753a165445efd097582eba7cf
https://doi.org/10.1021/acs.joc.1c01795
https://doi.org/10.1021/acs.joc.1c01795
Publikováno v:
Organic letters. 24(17)
A highly efficient enantioselective synthesis for the potent G-protein-coupled receptor 40 agonist MK-2305 was developed. The key tetrasubstituted olefin was prepared via a stereoselective Mukaiyama aldol reaction/elimination sequence. The highly ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fe361798fee685da8a235baeb21352
https://pubmed.ncbi.nlm.nih.gov/35467884
https://pubmed.ncbi.nlm.nih.gov/35467884
Autor:
Kevin R. Campos, Kevin M. Maloney, Li Zhang, Yong-Li Zhong, Daniel J. Muzzio, Guy R. Humphrey, Mark Weisel
Publikováno v:
Organic Process Research & Development. 24:1602-1608
Although diazeniumdiolates (DAZDs) and the synthetic methods to access DAZDs were discovered over 50 years ago, the current methodology is not safe, has a limited substrate scope, and is not amenab...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1752bde773bedc744de68fce6ff62e7b
https://doi.org/10.1021/acs.oprd.0c00067
https://doi.org/10.1021/acs.oprd.0c00067
Autor:
Zhixun Wang, Eric B. Sirota, Mark Weisel, John Y. L. Chung, Aaron M. Whittaker, Cyndi Qixin He, Donald R. Gauthier, François Lévesque, Danielle M. Schultz, Akasha K. Purohit, Yong-Li Zhong, Yingju Xu, Jonathan P. McMullen, Guy R. Humphrey, Varsolona Richard J, Cynthia M. Hong, Kevin M. Maloney
Publikováno v:
Organic Process Research & Development. 25:395-404
We report the practical synthesis of a key fragment of islatravir (MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor (NRTTI) currently under investigation for treatment and...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbb878695b7066d10e2d7723b11cd71a
https://doi.org/10.1021/acs.oprd.0c00304
https://doi.org/10.1021/acs.oprd.0c00304
Publikováno v:
The Journal of Organic Chemistry. 85:4807-4812
The therapeutic application of nitric oxide, an endogenous cellular signaling molecule, has been limited due to the difficulty of developing stable pro-drugs with slow kinetics of NO release. Diazeniumdiolates are valuable NO donors; however, synthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48e5529960a6e0702578b8db27d6e9f
https://doi.org/10.1021/acs.joc.0c00020
https://doi.org/10.1021/acs.joc.0c00020
Autor:
Andrew Brunskill, R. Thomas Williamson, Donald R. Gauthier, Mikhail Reibarkh, Yizhou Liu, Gary E. Martin, Yong-Li Zhong, Ikenna E. Ndukwe
Publikováno v:
Organic Letters. 21:4072-4076
Determining the configuration of proton-deficient molecules is challenging using conventional NMR methods including nuclear Overhauser effect (NOE) and the proton-dependent J-based configuration analysis (JBCA). The problem is exacerbated when only o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::701ec30569184d5864b28c0cc96a92f2
https://doi.org/10.1021/acs.orglett.9b01248
https://doi.org/10.1021/acs.orglett.9b01248
Autor:
Kevin R. Campos, Guy R. Humphrey, Mark Weisel, Yong-Li Zhong, Li Zhang, Kevin M. Maloney, Daniel J. Muzzio, Mark A. Huffman, Wendy Zhong
Publikováno v:
Organic Letters. 21:4210-4214
Synthetic diazeniumdiolate (DAZD)-based nitric oxide is utilized to modulate the nitric oxide (NO) concentration in cellular environments and to control physiological processes, yet chemists are still struggling to find efficient and scalable methodo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a11b0c1dafd9f81c74425e56e2bc5b5
https://doi.org/10.1021/acs.orglett.9b01401
https://doi.org/10.1021/acs.orglett.9b01401
Autor:
Jianguo Yin, David A. Thaisrivongs, Zhijian Liu, Nobuyoshi Yasuda, Adrian Goodyear, Ryan D. Cohen, Antony J. Davies, Brian C. Bishop, Peter R. Mullens, Kevin R. Campos, John Limanto, Ed Cleator, John S. Edwards, Mahbub Alam, Aaron M. Dumas, Hongming Li, Jingjun Yin, Lushi Tan, Zhiguo Jake Song, Yong-Li Zhong, William J. Morris, Michael Shevlin, Edward C. Sherer
Publikováno v:
The Journal of Organic Chemistry. 84:4780-4795
An asymmetric synthesis of HCV NS5B nucleoside polymerase inhibitor (1) is described. This novel route features several remarkably diastereoselective and high-yielding transformations, including construction of the all-carbon quaternary stereogenic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e13257ca1892584b4baff0f89a4446
https://doi.org/10.1021/acs.joc.8b02500
https://doi.org/10.1021/acs.joc.8b02500
Autor:
Feng Xu, Matthew D. Truppo, Hongming Li, Zhiguo J. Song, Yong-Li Zhong, Rebecca T. Ruck, Richard Desmond, Ji Qi, Tao Wang, Guy R. Humphrey, Jeonghan Park
Publikováno v:
Organic Letters. 19:5880-5883
A practical and asymmetric synthesis of a functionalized trans-cyclopropoxy building block for the preparation of the HCV NS3/4a protease inhibitor grazoprevir is reported. Intramolecular SN2 displacement–ring closure, followed by a Baeyer–Villig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd55ddc85520b4863b2892a5d3b0bc30
https://doi.org/10.1021/acs.orglett.7b02867
https://doi.org/10.1021/acs.orglett.7b02867