Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Yong‐Hui Zheng"'
Autor:
Wenqiang Su, Iqbal Ahmad, You Wu, Lijie Tang, Ilyas Khan, Bowei Ye, Jie Liang, Sunan Li, Yong‐Hui Zheng
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract Furin primarily localizes to the trans‐Golgi network (TGN), where it cleaves and activates a broad range of immature proproteins that play critical roles in cellular homeostasis, disease progression, and infection. Furin is retrieved from
Externí odkaz:
https://doaj.org/article/1728215f89c7485391b5ddd92a856fd1
Autor:
Ilyas Khan, Sunan Li, Lihong Tao, Chong Wang, Bowei Ye, Huiyu Li, Xiaoyang Liu, Iqbal Ahmad, Wenqiang Su, Gongxun Zhong, Zhiyuan Wen, Jinliang Wang, Rong-Hong Hua, Ao Ma, Jie Liang, Xiao-Peng Wan, Zhi-Gao Bu, Yong-Hui Zheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract SARS-CoV-2 and filovirus enter cells via the cell surface angiotensin-converting enzyme 2 (ACE2) or the late-endosome Niemann-Pick C1 (NPC1) as a receptor. Here, we screened 974 natural compounds and identified Tubeimosides I, II, and III as
Externí odkaz:
https://doaj.org/article/68a0dc87ebce45b18c3f12953aa84d2f
Autor:
Jing Zhang, Bin Wang, Xiaoxiao Gao, Cheng Peng, Chao Shan, Silas F. Johnson, Richard C. Schwartz, Yong-Hui Zheng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Little is known about how proteostasis is maintained during viral infection. Here, the authors identify unexpected crosstalk between the calnexin cycle, ERAD, and reticulophagy, resulting in suppression of ebolavirus glycoprotein expression.
Externí odkaz:
https://doaj.org/article/ae65b909852c47fabd4f56d608918dcc
Autor:
Tao Wang, Rui Luo, Jing Zhang, Zhanhao Lu, Lian-Feng Li, Yong-Hui Zheng, Li Pan, Jing Lan, Huanjie Zhai, Shujian Huang, Yuan Sun, Hua-Ji Qiu
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011580 (2023)
The multigene family genes (MGFs) in the left variable region (LVR) of the African swine fever virus (ASFV) genome have been reported to be involved in viral replication in primary porcine alveolar macrophages (PAMs) and virulence in pigs. However, t
Externí odkaz:
https://doaj.org/article/947fa34abfd143db850f82bc03d6043d
Autor:
Sunan Li, Rongrong Li, Iqbal Ahmad, Xiaomeng Liu, Silas F. Johnson, Liangliang Sun, Yong-Hui Zheng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
SERINC5 is a host-restriction factor preventing HIV progeny entry, which is counteracted by interactions with HIV Nef. Here, Li et al. show that E3 ubiquitin ligase Cullin 3 polyubiquitinates SERINC5 at Lys 130 via K48- and K33-linked ubiquitin chain
Externí odkaz:
https://doaj.org/article/c4048274c11c411aa2bf9ced27aa843f
Autor:
Qingqing Chai, Sunan Li, Morgan K. Collins, Rongrong Li, Iqbal Ahmad, Silas F. Johnson, Dylan A. Frabutt, Zhichang Yang, Xiaojing Shen, Liangliang Sun, Jian Hu, Judd F. Hultquist, B. Matija Peterlin, Yong-Hui Zheng
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109514- (2021)
Summary: HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5) by redirecting this potent restriction factor to the endosomes and lysosomes for degradation. However, the precise mechanism remains unclear. Using affinity puri
Externí odkaz:
https://doaj.org/article/699aa935e4094bf8a8df9c83d03630a5
Autor:
Changqing Yu, Sunan Li, Xianfeng Zhang, Ilyas Khan, Iqbal Ahmad, Yulong Zhou, Shuo Li, Jing Shi, Yu Wang, Yong-Hui Zheng
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Membrane-associated RING-CH-type 8 (MARCH8) strongly blocks human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) incorporation into virions by downregulating its cell surface expression, but the mechanism is still unclear.
Externí odkaz:
https://doaj.org/article/2072e260d8684d80bb2cee0ec0199e67
Autor:
Yue-Qing Yang, Yong-Hui Zheng, Chun-Ting Zhang, Wei-Wei Liang, Shu-Yu Wang, Xu-Dong Wang, Ying Wang, Tian-Hang Wang, Hong-Quan Jiang, Hong-Lin Feng
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Accumulation of DNA damage has been detected in the spinal cord of patients as well as in the G93A mouse model of amyotrophic lateral sclerosis (ALS). Wild-type p53-induced phosphatase 1 (Wip1) is a p53-inducible serine/threonine phosphatase that ter
Externí odkaz:
https://doaj.org/article/a4baac6980a84fb8925d7b1e4b7989e7
Publikováno v:
Tongxin xuebao, Vol 38, Pp 55-63 (2017)
The fully homomorphic encryption has important applications in the area of data security and privacy security of cloud computing,but the size of secret keys and ciphertext in most of current homomorphic encryption schemes were too large,which restric
Externí odkaz:
https://doaj.org/article/4cf59cbe714d42848ce294b541617e8d
Publikováno v:
Tongxin xuebao, Vol 38, Pp 66-75 (2017)
Fully homomorphic encryption is the best solution for solving privacy concerns for data over cloud so far,while large public key size is a general shortcoming for existing schemes.First,by introducing the concept of Kullback-Leibler divergence,an ide
Externí odkaz:
https://doaj.org/article/26af679a2511464dbc695c71fa55b58c