Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yonathan Goldtzvik"'
Autor:
Vaishali P. Waman, Paul Ashford, Su Datt Lam, Neeladri Sen, Mahnaz Abbasian, Laurel Woodridge, Yonathan Goldtzvik, Nicola Bordin, Jiaxin Wu, Ian Sillitoe, Christine A. Orengo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The COVID-19 disease is an ongoing global health concern. Although vaccination provides some protection, people are still susceptible to re-infection. Ostensibly, certain populations or clinical groups may be more vulnerable. Factors causing
Externí odkaz:
https://doaj.org/article/605cb58ddbd04446aebe2817798cb034
Autor:
Yonathan Goldtzvik, D. Thirumalai
Publikováno v:
Journal of Chemical Theory and Computation. 17:5358-5368
Conventional kinesin, a motor protein that transports cargo within cells, walks by taking multiple steps toward the plus end of the microtubule (MT). While significant progress has been made in understanding the details of the walking mechanism of ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb964b8ab10f8facc81b14e95a7e65f9
https://doi.org/10.1021/acs.jctc.1c00317
https://doi.org/10.1021/acs.jctc.1c00317
Autor:
Yonathan Goldtzvik, D. Thirumalai
Conventional kinesin, a motor protein that transports cargo within cells, walks by taking multiple steps towards the plus end of the microtubule (MT). While significant progress has been made in understanding the details of the walking mechanism of k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f70f1e38bc0367f5e3c8340e4d96011
https://doi.org/10.1101/2021.04.05.438476
https://doi.org/10.1101/2021.04.05.438476
Conventional kinesin, responsible for directional transport of cellular vesicles, takes multiple nearly uniform 8.2-nm steps by consuming one ATP molecule per step as it walks toward the plus end of the microtubule (MT). Despite decades of intensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbd9a1433e87e1c38f52355e6f1ca5b
https://europepmc.org/articles/PMC6859354/
https://europepmc.org/articles/PMC6859354/
1SummaryCytoplasmic Dynein, a motor with an unusual architecture made up of a motor domain belonging to the AAA+ family, walks on microtubule towards the minus end. Prompted by the availability of structures in different nucleotide states, we perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7928f5b5810edafa3e7d052bcbe4035
https://doi.org/10.1101/306589
https://doi.org/10.1101/306589
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Kinesin walks processively on microtubules (MTs) in an asymmetric hand-over-hand manner consuming one ATP molecule per 16 nm step. The contributions due to docking of the approximately thirteen residue neck linker to the leading head (deemed to be th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba75026b73ae1ee6c57cb234d4e38df
https://doi.org/10.1073/pnas.1706014114
https://doi.org/10.1073/pnas.1706014114
Publikováno v:
Chemical Physics. 415:168-172
Five small cyclic peptides and four implicit water models, were selected for this study. DEEPSAM, a structure prediction algorithm built upon TINKER, was used. Structures predicted using implicit water models were compared with experimental data, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96fea4db63cb0343a9161ade9e4fbc68
https://doi.org/10.1016/j.chemphys.2013.01.039
https://doi.org/10.1016/j.chemphys.2013.01.039
Conventional kinesin walks by a hand-over-hand mechanism on the microtubule (MT) by taking $\sim$ 8$nm$ discrete steps, and consumes one ATP molecule per step. The time needed to complete a single step is on the order of twenty microseconds. We show,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c5a04b9fdd3e8f344928929126000d
Publikováno v:
The journal of physical chemistry. B. 120(8)
Conventional kinesin walks by a hand-over-hand mechanism on the microtubule (MT) by taking ∼8 nm discrete steps and consumes one ATP molecule per step. The time needed to complete a single step is on the order of 20 μs. We show, using simulations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5115c51cafd0bec5101aebb306dedafd
https://pubmed.ncbi.nlm.nih.gov/26702870
https://pubmed.ncbi.nlm.nih.gov/26702870