Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Yonatan Y. Mahller"'
Autor:
Timothy P. Cripe, David P. Witte, Keith F. Stringer, Yonatan Y. Mahller, Zhengtao Chu, Xiaoyang Qi
Purpose: Saposin C is a multifunctional protein known to activate lysosomal enzymes and induce membrane fusion in an acidic environment. Excessive accumulation of lipid-coupled saposin C in lysosomes is cytotoxic. Because neoplasms generate an acidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2017e77f1935fd991cffbb531c559189
https://doi.org/10.1158/1078-0432.c.6517798.v1
https://doi.org/10.1158/1078-0432.c.6517798.v1
Autor:
Timothy P. Cripe, David P. Witte, Keith F. Stringer, Yonatan Y. Mahller, Zhengtao Chu, Xiaoyang Qi
Supplementary Data from Cancer-Selective Targeting and Cytotoxicity by Liposomal-Coupled Lysosomal Saposin C Protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abddbe834d1ef8043356fb15f9367bf
https://doi.org/10.1158/1078-0432.22440472.v1
https://doi.org/10.1158/1078-0432.22440472.v1
Autor:
Nancy Ratner, George Thomas, Sara C. Kozma, Heidi A. Lane, Timothy P. Cripe, John Perentesis, Takahiro Nobukuni, Mi-Ok Kim, Margaret H. Collins, Yonatan Y. Mahller, Gunnar Johansson
Malignant peripheral nerve sheath tumors (MPNST) are chemoresistant sarcomas with poor 5-year survival that arise in patients with neurofibromatosis type 1 (NF1) or sporadically. We tested three drugs for single and combinatorial effects on collected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb1b8475c4256fba5434d53f50d604c
https://doi.org/10.1158/1535-7163.c.6531741
https://doi.org/10.1158/1535-7163.c.6531741
Autor:
Nancy Ratner, George Thomas, Sara C. Kozma, Heidi A. Lane, Timothy P. Cripe, John Perentesis, Takahiro Nobukuni, Mi-Ok Kim, Margaret H. Collins, Yonatan Y. Mahller, Gunnar Johansson
Supplementary Fig. S1 from Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc40bc3ecbb07c09c0fa07d8883461b
https://doi.org/10.1158/1535-7163.22485042
https://doi.org/10.1158/1535-7163.22485042
Autor:
Timothy P. Cripe, Timothy M. Crombleholme, Jose A. Cancelas, Yoshinaga Saeki, William H. Baird, Maria C. Ripberger, Sachin S. Vaikunth, Yonatan Y. Mahller
Supplementary Figures 1-6 from Tissue Inhibitor of Metalloproteinase-3 via Oncolytic Herpesvirus Inhibits Tumor Growth and Vascular Progenitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5680cc47b80a38845697cd93316d1528
https://doi.org/10.1158/0008-5472.22374216.v1
https://doi.org/10.1158/0008-5472.22374216.v1
Autor:
Timothy P. Cripe, Timothy M. Crombleholme, Jose A. Cancelas, Yoshinaga Saeki, William H. Baird, Maria C. Ripberger, Sachin S. Vaikunth, Yonatan Y. Mahller
Malignant solid tumors remain a significant clinical challenge, necessitating innovative therapeutic approaches. Oncolytic viral therapy is a nonmutagenic, biological anticancer therapeutic shown to be effective against human cancer in early studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2085e01894136a13f9acc92b9a24157b
https://doi.org/10.1158/0008-5472.c.6497361
https://doi.org/10.1158/0008-5472.c.6497361
Autor:
Yonatan Y Mahller, Jon P Williams, William H Baird, Bryan Mitton, Jonathan Grossheim, Yoshinaga Saeki, Jose A Cancelas, Nancy Ratner, Timothy P Cripe
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4235 (2009)
Although disease remission can frequently be achieved for patients with neuroblastoma, relapse is common. The cancer stem cell theory suggests that rare tumorigenic cells, resistant to conventional therapy, are responsible for relapse. If true for ne
Externí odkaz:
https://doaj.org/article/47924a236a514fdd8916ce4e13f09067
Autor:
Timothy M. Crombleholme, Bruce J. Aronow, Timothy P. Cripe, Arturo R. Maldonado, Anil G. Jegga, Yonatan Y. Mahller, Chuck Klanke
Publikováno v:
The Journal of Gene Medicine. 12:613-623
Background Expression profile analyses of midkine (MDK), a multifunctional protein important in development but repressed postnataly, indicate that it is highly expressed in approximately 80% of adult carcinomas and many childhood cancers including m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a11acde1698fb60b0dab96c998ca1d1
https://doi.org/10.1002/jgm.1479
https://doi.org/10.1002/jgm.1479
Autor:
Ya-Hsuan Hsu, Baird Wh, Ruty Mehrian-Shai, Bhuvaneswari Sakthivel, Timothy P. Cripe, Yonatan Y. Mahller, Bruce J. Aronow
Publikováno v:
Cancer Gene Therapy. 15:733-741
Oncolytic herpes simplex viruses (oHSVs) are promising anticancer therapeutics. We sought to characterize the functional genomic response of human cancer cells to oHSV infection using G207, an oHSV previously evaluated in a phase I trial. Five human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b671ffc4a4298c83caa4de75b451bb76
https://doi.org/10.1038/cgt.2008.40
https://doi.org/10.1038/cgt.2008.40
Autor:
Rebecca A. Gillespie, E. Antonio Chiocca, Hirokazu Kambara, Nancy M. Sawtell, Greg Stroup, Timothy P. Cripe, Yonatan Y. Mahller, Margaret H. Collins, Mark A. Currier
Publikováno v:
Molecular Therapy. 16(5):879-885
Oncolytic herpes simplex virus (oHSV) mutants are under development as anticancer therapeutics. One such vector, rRp450, is ICP6-deleted and expresses a prodrug enzyme for cyclophosphamide (CPA) (rat CYP2B1). Little is known about rRp450's toxicity p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8742f311504dcc8f92789902d305f285