1H-NMR-based metabolomics reveals metabolic alterations in early development of a mouse model of Angelman syndrome

Autor: Pooja Kri Gupta, Sharon Barak, Yonatan Feuermann, Gil Goobes, Hanoch Kaphzan

Publikováno v: Molecular Autism, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Background Angelman syndrome (AS) is a rare neurodevelopmental genetic disorder caused by the loss of function of the ubiquitin ligase E3A (UBE3A) gene, affecting approximately 1:15,000 live births. We have recently shown that mitochondrial

Externí odkaz: https://doaj.org/article/747d783aa94048c998b5ee3fcded4752

IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation

Autor: Senthil Kumaran Satyanarayanan, Driss El Kebir, Soaad Soboh, Sergei Butenko, Meriem Sekheri, Janan Saadi, Neta Peled, Simaan Assi, Amira Othman, Sagie Schif-Zuck, Yonatan Feuermann, Dalit Barkan, Noa Sher, János G. Filep, Amiram Ariel

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Clearance of apoptotic neutrophils by macrophages is important for the resolution of inflammation. Here, the authors show that interferon-β produced by resolution phase macrophages promotes neutrophil apoptosis and efferocytosis and induces macropha

Externí odkaz: https://doaj.org/article/bde7b79a24f74c988fe97e64005be189

Mammary Fat Can Adjust Prolactin Effect on Mammary Epithelial Cells via Leptin and Estrogen

Autor: Yonatan Feuermann, Sameer J. Mabjeesh, Avi Shamay

Publikováno v: International Journal of Endocrinology, Vol 2009 (2009)

Leptin, like estrogen, is one of the endo/paracrine factors, which are synthesized in and secreted from mature adipocytes. The roles of the mammary fat pad and mammary adipocytes in the initiation of lactation are not clear. In this study, we showed

Externí odkaz: https://doaj.org/article/f716bbc1e6ac449b84f882939d517670

Sex-Dependent Sensory Phenotypes and Related Transcriptomic Expression Profiles Are Differentially Affected by Angelman Syndrome

Autor: Lital Sharvit, Yonatan Feuermann, Lilach Simchi, Julia Panov, Prudhvi Raj Rayi, Hanoch Kaphzan, Lee Koyavski

Publikováno v: Molecular Neurobiology. 56:5998-6016

Angelman syndrome (AS) is a genetic disorder which entails autism, intellectual disability, lack of speech, motor deficits, and seizure susceptibility. It is caused by the lack of UBE3A protein expression, which is an E3-ubiquitin ligase. Despite AS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7aa9e6b462923aedf8dd7f267dad73e
https://doi.org/10.1007/s12035-019-1503-8

Novel Insights into the Role of UBE3A in Regulating Apoptosis and Proliferation

Autor: Hanoch Kaphzan, Julia Panov, Olla Morsy, Lilach Simchi, Yonatan Feuermann

Publikováno v: Journal of Clinical Medicine, Vol 9, Iss 1573, p 1573 (2020)
Journal of Clinical Medicine; Volume 9; Issue 5; Pages: 1573
Journal of Clinical Medicine

The UBE3A gene codes for a protein with two known functions, a ubiquitin E3-ligase which catalyzes ubiquitin binding to substrate proteins and a steroid hormone receptor coactivator. UBE3A is most famous for its critical role in neuronal functioning.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8a5f26ee9f930a99a96f989af29717
https://www.mdpi.com/2077-0383/9/5/1573