Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yonatan Eliezer"'
Autor:
Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer, Giuseppina De Feudis, Eli Reuveni, Anouk Savir Kadmon, Sara Martin, Sonia Viganò, Gil Leor, James Berstler, Julia Muenzner, Michael Mülleder, Emma M. Campagnolo, Eldad D. Shulman, Tiangen Chang, Carmela Rubolino, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Silvia Taglietti, Alice Ratti, Chani Stossel, Talia Golan, Francesco Nicassio, Eytan Ruppin, Markus Ralser, Francisca Vazquez, Uri Ben-David, Stefano Santaguida
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with aneuploidy-induced cellular stresses remain largely unknown. Here, we induce chromosome mis-segregation in non-transformed RPE1-hTERT cells and derive multip
Externí odkaz:
https://doaj.org/article/39fb3782127942b7a41803d50388bb0d
Autor:
Lorenza Garribba, Giuseppina De Feudis, Valentino Martis, Martina Galli, Marie Dumont, Yonatan Eliezer, René Wardenaar, Marica Rosaria Ippolito, Divya Ramalingam Iyer, Andréa E. Tijhuis, Diana C. J. Spierings, Michael Schubert, Silvia Taglietti, Chiara Soriani, Simon Gemble, Renata Basto, Nick Rhind, Floris Foijer, Uri Ben-David, Daniele Fachinetti, Ylli Doksani, Stefano Santaguida
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Chromosomal instability leads to aneuploidy, a state of karyotype imbalance. By inducing controlled chromosome mis-segregation, Santaguida and colleagues show that aneuploidy can also instigate chromosomal instability.
Externí odkaz:
https://doaj.org/article/e226f0a659b0484e8d7815070b875a08
Autor:
Marica Rosaria Ippolito, Johanna Zerbib, Yonatan Eliezer, Eli Reuveni, Sonia Viganò, Giuseppina De Feudis, Anouk Savir Kadmon, Ilaria Vigorito, Sara Martin, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Francisca Vazquez, Stefano Santaguida, Uri Ben-David
Aneuploidy, an abnormal chromosome composition, results in a stoichiometric imbalance of protein complexes, which jeopardizes the fitness of aneuploid cells. Aneuploid cells thus need to compensate for the imbalanced DNA levels by regulating their RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d18fb3abaa4827fc89c783f62141cbda
https://doi.org/10.1101/2023.01.27.525826
https://doi.org/10.1101/2023.01.27.525826
Autor:
Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer, Giuseppina De Feudis, Eli Reuveni, Anouk Savir Kadmon, Sara Martin, Sonia Viganò, Gil Leor, James Berstler, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Francisca Vazquez, Uri Ben-David, Stefano Santaguida
Aneuploidy is a hallmark of human cancer, yet the cellular mechanisms that allow cells to cope with aneuploidy-induced cellular stresses remain largely unknown. Such coping mechanisms may present cellular vulnerabilities that can be harnessed for tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55d6dfffbbebdc391fabd111e83f8a20
https://doi.org/10.1101/2023.01.27.525822
https://doi.org/10.1101/2023.01.27.525822
Autor:
Kavya Prasad, Mathew Bloomfield, Hagai Levi, Kristina Keuper, Sara V. Bernhard, Nicolaas C. Baudoin, Gil Leor, Yonatan Eliezer, Maybelline Giam, Cheng Kit Wong, Giulia Rancati, Zuzana Storchová, Daniela Cimini, Uri Ben-David
Publikováno v:
Cancer Res
Aneuploidy is a hallmark of cancer with tissue-specific prevalence patterns that suggest it plays a driving role in cancer initiation and progression. However, the contribution of aneuploidy to tumorigenesis depends on both cellular and genomic conte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68879913814bc15d468354095253ac25
https://europepmc.org/articles/PMC9069772/
https://europepmc.org/articles/PMC9069772/
Autor:
Yonatan Eliezer, Uri Ben-David
Publikováno v:
Nature. 604:44-45