Signaling across the Platelet Adhesion Receptor Glycoprotein Ib-IX Induces αIIbβ3 Activation Both in Platelets and a Transfected Chinese Hamster Ovary Cell System

Autor: Sylvie C. Meyer, Kumar B. Reddy, Joan E.B. Fox, Emil Negrescu, Yona Zaffran

Publikováno v: Journal of Biological Chemistry. 275:16779-16787

In platelets, alpha(IIb)beta(3) exists in a form that cannot bind adhesive proteins in the plasma; although it can interact with immobilized fibrinogen it cannot interact with immobilized von Willebrand factor in the vessel wall. Soluble agonists suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a874ba4e5a5a91e08919fee34ef2b05
https://doi.org/10.1074/jbc.275.22.16779

14-3-3 zeta mediates integrin-induced activation of Cdc42 and Rac. Platelet glycoprotein Ib-IX regulates integrin-induced signaling by sequestering 14-3-3 zeta

Autor: Katarzyna, Bialkowska, Yona, Zaffran, Sylvie C, Meyer, Joan E B, Fox

Publikováno v: The Journal of biological chemistry. 278(35)

Integrin-induced cytoskeletal reorganizations are initiated by Cdc42 and Rac1 but little is known about mechanisms by which integrins activate these Rho GTPases. 14-3-3 proteins are adaptors implicated in binding and regulating the function and subce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d1c1f9555f3a8e06332135f012d39bc8
https://pubmed.ncbi.nlm.nih.gov/12810725

Role of CR4 in Mycobacterium tuberculosis-human macrophages binding and signal transduction in the absence of serum

Autor: Jerrold J. Ellner, Yona Zaffran, Li Zhang

Publikováno v: Infection and immunity. 66(9)

The β2 integrin CR4 is involved in Mycobacterium tuberculosis phagocytosis by human mononuclear phagocytes through the opsonin C3bi. In this study, we demonstrate that M. tuberculosis can bind directly to monocyte-derived macrophages via CR4 in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c06b5d142cb6750c223f0baedeba46
https://pubmed.ncbi.nlm.nih.gov/9712816

Morphological polarization of human polymorphonuclear leucocytes in response to three different chemoattractants: an effector response independent of calcium rise and tyrosine kinases

Autor: J.L. Ansaldi, J. L. Mege, Hubert Lepidi, Yona Zaffran, Christian Capo

Publikováno v: Journal of cell science. 108

Chemoattractants such as interleukin-8, C5a and N-formylmethionyl-leucyl-phenylalanine induce a cytosolic calcium rise involved in triggering the secretory functions of human polymorphonuclear leucocytes. We studied the possible role of calcium rise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab774102a3335c3e44c92f61bba491aa
https://pubmed.ncbi.nlm.nih.gov/7615691

CD46/CD3 costimulation induces morphological changes of human T cells and activation of Vav, Rac, and extracellular signal-regulated kinase mitogen-activated protein kinase

Autor: Anne Astier, Stéphane Ory, Pierre Jurdic, Agnès Roux, Olivier Destaing, Chantal Rabourdin-Combe, Thao Nheu, Yona Zaffran

Publikováno v: CIÊNCIAVITAE
Journal of Immunology
Journal of Immunology, 2001, 167 (12), pp.6780-6785. ⟨10.4049/jimmunol.167.12.6780⟩
Scopus-Elsevier
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2001, 167 (12), pp.6780-6785. ⟨10.4049/jimmunol.167.12.6780⟩

Efficient T cell activation requires at least two signals, one mediated by the engagement of the TCR-CD3 complex and another one mediated by a costimulatory molecule. We recently showed that CD46, a complement regulatory receptor for C3b as well as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ee0405838e034a5ec1f30c22f2e5ca
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035892881&partnerID=MN8TOARS