Perspective of mesenchymal transformation in glioblastoma

Autor: Yona Kim, Frederick S. Varn, Sung-Hye Park, Byung Woo Yoon, Hye Ran Park, Charles Lee, Roel G. W. Verhaak, Sun Ha Paek

Publikováno v: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-20 (2021)

Abstract Despite aggressive multimodal treatment, glioblastoma (GBM), a grade IV primary brain tumor, still portends a poor prognosis with a median overall survival of 12–16 months. The complexity of GBM treatment mainly lies in the inter- and intr

Externí odkaz: https://doaj.org/article/f9d5a299ebbd44bc8b99d034e1b64aff

Perspective of mesenchymal transformation in glioblastoma

Autor: Sun Ha Paek, Roel G.W. Verhaak, Byung Woo Yoon, Sung Hye Park, Charles Lee, Hye Ran Park, Yona Kim, Frederick S. Varn

Publikováno v: Acta Neuropathologica Communications
Kim, Y, Varn, F S, Park, S-H, Yoon, B W, Park, H R, Lee, C, Verhaak, R G W & Paek, S H 2021, ' Perspective of mesenchymal transformation in glioblastoma ', Acta neuropathologica communications, vol. 9, no. 1, 50 . https://doi.org/10.1186/s40478-021-01151-4
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-20 (2021)

Despite aggressive multimodal treatment, glioblastoma (GBM), a grade IV primary brain tumor, still portends a poor prognosis with a median overall survival of 12–16 months. The complexity of GBM treatment mainly lies in the inter- and intra-tumoral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881a959ca72d16d88dd98042014ec994
https://doi.org/10.1186/s40478-021-01151-4

Development of a patient-derived xenograft model of glioblastoma via intravitreal injection in mice

Autor: Dong Gyu Kim, Seung Ho Yoo, Yona Kim, Sun Ha Paek, Hye Ran Park, Jiwon Esther Han, Young Suk Yu, Jeong Hun Kim, Jooyoung Lee, Dong Hyun Jo, Jin Hyoung Kim, Chang Sik Cho, Hyo Eun Moon, Hyoungwoo Park

Publikováno v: Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 51, Iss 4, Pp 1-9 (2019)

Currently, the two primary patient-derived xenograft (PDX) models of glioblastoma are established through intracranial or subcutaneous injection. In this study, a novel PDX model of glioblastoma was developed via intravitreal injection to facilitate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0e3554e6799a73dcb6f79f6172260c
https://pubmed.ncbi.nlm.nih.gov/30992429

Human umbilical cord blood-derived mesenchymal stem cells improve functional recovery through thrombospondin1, pantraxin3, and vascular endothelial growth factor in the ischemic rat brain

Autor: Sun Ha Paek, Hye Ryoun Kim, Wonil Oh, Hyung Woo Park, Yoon Sun Yang, Dong Gyu Kim, Seung Leal Paek, Kwanwoo Kim, Jong Wook Chang, Hyo Eun Moon, Jin Wook Kim, Yona Kim, Jae Ha Hwang

Publikováno v: Journal of Neuroscience Research. 93:1814-1825

Cell therapy is a potential therapeutic method for cerebral ischemia, which remains a serious problem. In the search for more effective therapeutic methods, many kinds of stem cells from various tissues have been developed and tested as candidate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8e5c9e1992d6ee7db0987ad33aca72f
https://doi.org/10.1002/jnr.23616

Chromatin Profiling Reveals Regulatory Network Shifts and a Protective Role for Hepatocyte Nuclear Factor 4α during Colitis

Autor: Douglas Londono, Yona Kim, Joshua K. Thackray, Sanjay Chahar, Anthony Musolf, Michael P. Verzi, Kinjal Desai, Mathieu Lupien, Vishal Gandhi, Richard Cowper-Sal·lari, Nan Gao, Namit Kumar, Ansu O. Perekatt, Andrew Hoffman, Hyunjin Shin, Nikhil Kumar, Berta N. Vazquez, Shiyan Yu, Lourdes Serrano

Publikováno v: Molecular and Cellular Biology. 34:3291-3304

Transcriptional regulatory mechanisms likely contribute to the etiology of inflammatory bowel disease (IBD), as genetic variants associated with the disease are disproportionately found at regulatory elements. However, the transcription factors regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948636f49e6418398e83e40e828405a2
https://doi.org/10.1128/mcb.00349-14