Výsledky vyhledávání - "Yolande Herve"

Synthesis of benzyl (6S)-1,3-dichloro-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic ester, a new conformationally constrained peptidomimetic derivative

Autor: Guillaume De Nanteuil, Jean-Pierre Lecouve, Nathalie Bremand, Yolande Herve, Fabienne Breard, Philippe Gloanec

Publikováno v: Tetrahedron Letters. 43:3499-3501

We describe the synthesis of benzyl (6S)-1,3-dichloro-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic ester, a new conformationally constrained peptidomimetic derivative. This compound is prepared in seven steps from (S)-pyroglutamic aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::221b2bce5be50595dff436cd9dd2ab09
https://doi.org/10.1016/s0040-4039(02)00574-9

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Asymmetric conjugate additions of chiral allyl- and crotylphosphonamide anions to .alpha.,.beta.-unsaturated carbonyl compounds: highly stereocontrolled access to vicinally substituted carbon centers and chemically asymmetrized chirons

Autor: Stephen Hanessian, Serge Beaudoin, Arthur Gomtsyan, Yolande Herve, Andrew D Payne

Publikováno v: The Journal of Organic Chemistry. 58:5032-5034

Reactions of anions derived from chiral nonracemic allyl and crotyl bicyclic phosphonamides with α,β-unsaturated cyclic ketones, esters, lactones, and lactams take place at the γ-position of the reagents and lead to diastereomerically pure or high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::162a1a1ecee9f318725c64cec5175ff5
https://doi.org/10.1021/jo00071a004

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New prolyl endopeptidase inhibitors: in vitro and in vivo activities of azabicyclo[2.2.2]octane, azabicyclo[2.2.1]heptane, and perhydroindole derivatives

Autor: B. Portevin, Jean M. Lepagnol, Yolande Herve, A. Benoist, M. Vincent, G. De Nanteuil, G. Remond

Publikováno v: Journal of medicinal chemistry. 39(12)

A series of potent and selective prolylendopeptidase (PEP) inhibitors of the alpha-keto heterocyclic type has been obtained by replacing the classical central proline of 1-[1-(4-phenylbutanoyl)-L-prolyl]pyrrolidine (SUAM 1221,3) by non-natural amino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02fd9b751b52f4ee9f8a654208d2544
https://pubmed.ncbi.nlm.nih.gov/8691432

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Synthesis of 2S, 3aS, 7aS- and of 2S, 3aR, 7aR-Perhydroindole-2-carboxylic acid derivatives from L-aspartic acid

Autor: Pierre Potier, Derek H.R. Barton, Yolande Herve, Josiane Thierry, Jean Guilhem

Publikováno v: Tetrahedron Letters. 28:1413-1416

Using carbon radicals generated by photolysis of N -hydroxy-2-thio-pyridone esters (mixed anhydrides) the chiral centre of L -aspartic acid has been easily incorporated into the perhydroindole structure of the title compounds.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76ece335d31ee5ab708582b3e5f2cb8f
https://doi.org/10.1016/s0040-4039(00)95940-9

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Synthesis of novel α-amino-acids and derivatives using radical chemistry: synthesis of - and -α-amino-adipic acids, -α

Autor: Josiane Thierry, Derek H.R. Barton, Yolande Herve, Pierre Potier

Publikováno v: Tetrahedron. 43:4297-4308

Radicals generated by photolysis (W light) of suitably protected amino-acid derivatives of N -hydroxy-2-thiopyridone add efficiently to activated olefins to afford satisfactory yields of adducts. Oxidation of the thiopyridyl residue to sulphoxide and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fbeb1c221c4d21ce83f9890394ed40b
https://doi.org/10.1016/s0040-4020(01)90305-9

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The free radical chemistry of carboxylic esters of 2-selenopyridine--oxide: a convenient synthesis of (L)-vinylglycine

Autor: David Crich, Pierre Potier, Derek H.R. Barton, Josiane Thierry, Yolande Herve

Publikováno v: Tetrahedron. 41:4347-4357

Optically pure (L)-vinylglycine has been synthesised by two different methods. The first of these involves protected (L)-glutamate esters of N -hydroxy-2-seleno-pyridine. Such esters are shown to undergo the same decarboxylotive rearrangement as thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ada868fd6a62ebd344bf7a1ef164902
https://doi.org/10.1016/s0040-4020(01)97206-0

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Concise syntheses of L-selenomethionine and of L-selenocystine using radical chain reactions

Autor: Josiane Thierry, Yolande Herve, Samir Z. Zard, Pierre Potier, Derek H.R. Barton, D. Bridon

Publikováno v: Tetrahedron. 42:4983-4990

L-Selenomethionine and L-selenocystine were prepared in high overall yields from protected L-glutamic and L-aospartic acid derivatives respectively. Irradiation of the mixed anhydrides (esters) derived from 4 (e.g. 15 ) in the presence of dimethyldis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dd42ca60b4046b30a1656398b533908
https://doi.org/10.1016/s0040-4020(01)88049-2

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