Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yolanda Cancho Grande"'
Autor:
Sven Wittrock, Carsten Terjung, Anne-Sophie Rebstock, Nils Griebenow, Anette Sommer, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Yolanda Cancho-Grande, Christoph Mahlert, Sarah Johannes, Sandra Berndt, Simone Greven
Publikováno v:
Angewandte Chemie International Edition. 57:15243-15247
The number of cytotoxic payload classes successfully employed in antibody-drug conjugates (ADCs) is still rather limited. The identification of ADC payloads with a novel mode of action will increase therapeutic options and potentially increase the th
Autor:
Anette Sommer, Carsten Terjung, Yolanda Cancho-Grande, Beatrix Stelte-Ludwig, Anne-Sophie Rebstock, Sven Wittrock, Christoph Mahlert, Hans-Georg Lerchen, Sarah Johannes, Simone Greven, Nils Griebenow, Sandra Berndt
Publikováno v:
Angewandte Chemie International Edition. 57:14950-14950
Autor:
Thomas Lampe, Winfried Jöntgen, Siegfried Raddatz, Holger Paulsen, Mathias Berwe, Martin Michels, Jochen Krüger, Stefan Weigand, Yolanda Cancho-Grande
Publikováno v:
Organic Process Research & Development. 15:1348-1357
We describe the evolution of a kilogram-scale synthesis of the protected cyclic tripeptide desoxy-biphenomycin B, based on an early discovery route. The retrosynthetic concept included a macrolactamization strategy to build the core ring system of bi
Autor:
Nils Griebenow, Sarah Johannes, Anne-Sophie Rebstock, Carsten Terjung, Anette Sommer, Beatrix Stelte-Ludwig, Simone Greven, Christoph Mahlert, Yolanda Cancho-Grande, Hans-Georg Lerchen, Sven Wittrock, Sandra Berndt
Publikováno v:
Angewandte Chemie. 130:15166-15166
Autor:
Heiner Apeler, Nils Griebenow, Anette Sommer, Christoph Mahlert, Simone Greven, Anne-Sophie Rebstock, Sandra Berndt, Sven Wittrock, Carsten Terjung, Mario Lobell, Bertolt Kreft, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Yolanda Cancho-Grande, Rolf Jautelat
Publikováno v:
Cancer Research. 77:3234-3234
The number of cytotoxic payload classes with different modes-of-action which have been successfully employed in antibody-drug conjugates (ADC) is still rather limited. So far, only ADCs with microtubule inhibitors, DNA binding payloads or topoisomera
Autor:
Anette Sommer, Sven Wittrock, Heiner Apeler, Hans-Georg Lerchen, Rolf Jautelat, Bertolt Kreft, Simone Greven, Yolanda Cancho-Grande, Sandra Berndt, Anne-Sophie Rebstock, Nils Griebenow, Lisa Dietz, Beatrix Stelte-Ludwig, Christoph Mahlert
Publikováno v:
Cancer Research. 77:46-46
Antibody-drug conjugates (ADCs) are promising agents that are developed for targeted delivery of cytotoxic payloads to tumor cells. ADCs share a common design of antibody, linker, and cytotoxic payload. Despite significant efforts, the number of avai
Publikováno v:
ChemInform. 33
Autor:
Yolanda Cancho Grande, Jochen Krueger, Rainer Endermann, Reinhold Gahlmann, Michael Brands, Siegfried Raddatz
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(16)
We report the synthesis and pharmacological evaluation of new derivatives of the natural dipeptide antibiotic TAN 1057 A,B containing heterocycles either in the beta-amino acid side chain or as mimics of the urea function. In the course of this progr
Autor:
Mathias Berwe, Winfried JoÌntgen, Jochen KruÌger, Yolanda Cancho-Grande, Thomas Lampe, Martin Michels, Holger Paulsen, Siegfried Raddatz, Stefan Weigand
Publikováno v:
Organic Process Research & Development; Nov2011, Vol. 15 Issue 6, p1348-1357, 10p