Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yolanda, Caringal"'
Autor:
Dezhi Xing, John Lloyd, Karnail S. Atwal, Mei Mann Hsueh, Yolanda Caringal, Ruth R. Wexler, Alexander Kover, Paul Levesque, Ji Jiang, Timothy W. Harper, Mary Lee Conder, Heather Finlay, Michael A. Blanar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1743-1747
Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of IKur current. Syntheses and SAR for C6 triazolo and imidazo dihydropyrazolopyrimidines series are described. Trifluoromethylcyclohexyl N(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e51799a21b73f50199fc9a444acca4
https://doi.org/10.1016/j.bmcl.2013.01.064
https://doi.org/10.1016/j.bmcl.2013.01.064
Autor:
A A Seymour, William N. Washburn, Dorothy Slusarchyk, P.J. McCann, B.E. Abboa-Offei, Minsheng Zhang, G.T. Allen, Ravindar N. Girotra, B.H. Frohlich, Michael Cap, Jollie D. Godfrey, Peter T. W. Cheng, R.J. George, C. Shao, Anita D. Russell, S. Skwish, Philip M. Sher, Jon J. Hangeland, A.V. Gavai, T.L. Waldron, Belay Tesfamariam, Yolanda Caringal, T.W. Harper, Tamara Dejneka, Kenneth E.J. Dickinson, Ginger Wu, Syed Z. Ahmed, Amarendra B. Mikkilineni, Hongwei Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4290-4296
Utilization of N-substituted-4-hydroxy-3-methylsulfonanilidoethanolamines 1 as selective beta(3) agonists is complicated by their propensity to undergo metabolic oxidative N-dealkylation, generating 0.01-2% of a very potent alpha(1) adrenergic agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db28be835bfadb1da0ebd09bad48db49
https://doi.org/10.1016/j.bmcl.2007.05.030
https://doi.org/10.1016/j.bmcl.2007.05.030
Autor:
Huabin Sun, Joseph Prol, Karnail S. Atwal, T.W. Harper, Yolanda Caringal, Michael A. Blanar, Ruth R. Wexler, Jinping Gan, Christine Huang, Wayne Vaccaro, Alexander Kover, Paul Levesque, Heather Finlay, Lin Yan, John Lloyd, John D. Dimarco, Mary Lee Conder, Tram N. Huynh, Bhandaru Rao S, Gauri Bhave
Publikováno v:
Journal of medicinal chemistry. 55(7)
Previously disclosed dihydropyrazolopyrimidines are potent and selective blockers of I(Kur) current. A potential liability with this chemotype is the formation of a reactive metabolite which demonstrated covalent binding to protein in vitro. When sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839ac692afc55a7651f54a83a704a341
https://pubmed.ncbi.nlm.nih.gov/22409629
https://pubmed.ncbi.nlm.nih.gov/22409629
Autor:
Frank M. Hauser, Yolanda Caringal
Publikováno v:
The Journal of Organic Chemistry. 55:555-559
Une synthese totale de la [dihydro-5,6 methyl-2 hydroxy-7]benzo[a] naphtacenedione-8,13 (A) substituee par trimethoxy-4,9,12 a ete realisee regiospecifiquement; cette synthese a permis de determiner la structure du trimethyle ester du G-2N comme etan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d279228502353c026f7e8490819c5c7
https://doi.org/10.1021/jo00289a030
https://doi.org/10.1021/jo00289a030
Autor:
Johnny Sandberg, Karin Mellström, Mahmoud Rahimi-Ghadim, Denis E. Ryono, Gary J. Grover, Zhang Minsheng, Peter Agback, Neeraj Garg, William N. Washburn, Marlena Grynfarb, Ana Maria Garcia Collazo, Yolanda Caringal, Wei Meng, Robert Paul Brigance, Yi-Lin Li, Stefan Rehnmark, Chris Litten, Johan Malm, Thomas Anders Norin
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(15)
Based on the scaffold of the pharmacologically selective thyromimetic 2b, structurally a close analog to KB-141 (2a), a number of novel N-acylated-α-amino acid derivatives were synthesized and tested in a TR radioligand binding assay as well as in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6bb5791e4a353bc0947c7e11b1cc9ca
https://pubmed.ncbi.nlm.nih.gov/17543524
https://pubmed.ncbi.nlm.nih.gov/17543524
Autor:
Uday R, Khire, Donald, Bankston, James, Barbosa, David R, Brittelli, Yolanda, Caringal, Robert, Carlson, Jacques, Dumas, Todd, Gane, Sarah L, Heald, Barbara, Hibner, Jeffrey S, Johnson, Michael E, Katz, Nancy, Kennure, Jill, Kingery-Wood, Wendy, Lee, Xiao-Gao, Liu, Timothy B, Lowinger, Ian, McAlexander, Mary-Katherine, Monahan, Reina, Natero, Joel, Renick, Bernd, Riedl, Hong, Rong, Robert N, Sibley, Roger A, Smith, Donald, Wolanin
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(3)
Bis-aryl ureas have been disclosed previously as a potent class of Raf kinase inhibitors. Modifications in the amide portion led to an improvement in aqueous solubility, an important characteristic for an oral drug. Based on this finding, we hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79292863887c92f448aa8823dbad5d77
https://pubmed.ncbi.nlm.nih.gov/14741289
https://pubmed.ncbi.nlm.nih.gov/14741289
Autor:
Heather J. Finlay, John Lloyd, Wayne Vaccaro, Alexander Kover, Lin Yan, Gauri Bhave, Joseph Prol, Tram Huynh, Rao Bhandaru, Yolanda Caringal, John DiMarco, Jinping Gan, Tim Harper, Christine Huang, Mary Lee Conder, Huabin Sun, Paul Levesque, Michael Blanar, Karnail Atwal, Ruth Wexler
Publikováno v:
Journal of Medicinal Chemistry. 56:7133-7133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34e502f4948210914df68a9cbb04ee89
https://doi.org/10.1021/jm4010576
https://doi.org/10.1021/jm4010576
Autor:
Yolanda Caringal, Frank M. Hauser
Publikováno v:
ChemInform. 21
As outlined in the reaction scheme, the hexahydrobenzonaphthacenone (III) is formed by cyclocondensation of the phthalide sulfone (I) with the hydrophenanthrone (II).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a343d9d5dc863049966fa7f0c59a990c
https://doi.org/10.1002/chin.199025140
https://doi.org/10.1002/chin.199025140