Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Yoland Smith"'
Autor:
Alissandra de Moura Gomes, Terri L. Petkau, Andrea J. Korecki, Oriol Fornes, Adriana Galvan, Ge Lu, Austin M. Hill, Siu Ling Lam, Anqi Yao, Rachelle A. Farkas, Wyeth W. Wasserman, Yoland Smith, Elizabeth M. Simpson, Blair R. Leavitt
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Compact cell type-specific promoters are important tools for basic and preclinical research and clinical delivery of gene therapy. In this work, we designed novel MiniPromoters to target D1 and D2 type dopaminoceptive medium spiny neurons in
Externí odkaz:
https://doaj.org/article/ccbb413e18624dfaadafe59f90e06ce7
Autor:
J. Lucas McKay, Jonathan Nye, Felicia C. Goldstein, Barbara Sommerfeld, Yoland Smith, David Weinshenker, Stewart A. Factor
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106048- (2023)
Background: Freezing of gait (FOG) is a major cause of falling in Parkinson's disease (PD) and can be responsive or unresponsive to levodopa. Pathophysiology is poorly understood. Objective: To examine the link between noradrenergic systems, the deve
Externí odkaz:
https://doaj.org/article/1be36660667442c3ab69268f36d48aeb
Publikováno v:
Frontiers in Systems Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/291cdd7959a44aada80a63e9b9312a0c
Autor:
Anthony W.S. Chan, In Ki Cho, Chun-Xia Li, Xiaodong Zhang, Sudeep Patel, Rebecca Rusnak, Jessica Raper, Jocelyne Bachevalier, Sean P. Moran, Tim Chi, Katherine H. Cannon, Carissa E. Hunter, Ryan C. Martin, Hailian Xiao, Shang-Hsun Yang, Sanjeev Gumber, James G. Herndon, Rebecca F. Rosen, William T. Hu, James J. Lah, Allan I. Levey, Yoland Smith, Lary C. Walker
Publikováno v:
Aging Brain, Vol 2, Iss , Pp 100044- (2022)
With the ultimate goal of developing a more representative animal model of Alzheimer's disease (AD), two female amyloid-β-(Aβ) precursor protein-transgenic (APPtg) rhesus monkeys were generated by lentiviral transduction of the APP gene into rhesus
Externí odkaz:
https://doaj.org/article/e37b891206f5479e91e23e9f894ea295
Autor:
Valerie Joers, Gunasingh Masilamoni, Doty Kempf, Alison R. Weiss, Travis M. Rotterman, Benjamin Murray, Gul Yalcin-Cakmakli, Ronald J. Voll, Mark M. Goodman, Leonard Howell, Jocelyne Bachevalier, Stefan J. Green, Ankur Naqib, Maliha Shaikh, Phillip A. Engen, Ali Keshavarzian, Christopher J. Barnum, Jonathon A. Nye, Yoland Smith, Malú G. Tansey
Publikováno v:
Neurobiology of Disease, Vol 144, Iss , Pp 105027- (2020)
Inflammation has been linked to the development of nonmotor symptoms in Parkinson's disease (PD), which greatly impact patients' quality of life and can often precede motor symptoms. Suitable animal models are critical for our understanding of the me
Externí odkaz:
https://doaj.org/article/43c19177d7114cb980da723d241e3f02
Autor:
Jinxu Liu, Gajanan P. Shelkar, Pauravi J. Gandhi, Dinesh Y. Gawande, Andrew Hoover, Rosa M. Villalba, Ratnamala Pavuluri, Yoland Smith, Shashank M. Dravid
Publikováno v:
Neurobiology of Disease, Vol 137, Iss , Pp 104746- (2020)
Impaired behavioral flexibility and repetitive behavior is a common phenotype in autism and other neuropsychiatric disorders, but the underlying synaptic mechanisms are poorly understood. The trans-synaptic glutamate delta (GluD)-Cerebellin 1-Neurexi
Externí odkaz:
https://doaj.org/article/2139a52e8f8145b797a84cf5427e05f7
Publikováno v:
Neurobiology of Disease, Vol 100, Iss , Pp 9-18 (2017)
There is anatomical and functional evidence that ventral midbrain dopaminergic (DA) cell groups and the subthalamic nucleus (STN) receive noradrenergic innervation in rodents, but much less is known about these interactions in primates. Degeneration
Externí odkaz:
https://doaj.org/article/b00f0e2f54ad409f8b32b3e6273668a0
Autor:
Gul Yalcin-Cakmakli, Samuel J. Rose, Rosa M. Villalba, Lagena Williams, Hyder A. Jinnah, Ellen J. Hess, Yoland Smith
Publikováno v:
Frontiers in Systems Neuroscience, Vol 12 (2018)
Striatal cholinergic dysfunction is a common phenotype associated with various forms of dystonia in which anti-cholinergic drugs have some therapeutic benefits. However, the underlying substrate of striatal cholinergic defects in dystonia remain poor
Externí odkaz:
https://doaj.org/article/83f588d0972c4ac798b7ec0b5b08b104
Publikováno v:
Neurobiology of Disease, Vol 74, Iss , Pp 254-262 (2015)
GluN2B subunit containing NMDARs (GluN2B-NMDARs) mediate pathophysiological effects of acutely applied amyloid beta (Aβ), including impaired long-term potentiation (LTP). However, in transgenic Alzheimer's disease (AD) mouse models which feature gra
Externí odkaz:
https://doaj.org/article/e2d55adc4687495981e5ce9ada8619a3
Autor:
Stefka Gyoneva, Lauren Shapiro, Carlos Lazo, Ethel Garnier-Amblard, Yoland Smith, Gary W. Miller, Stephen F. Traynelis
Publikováno v:
Neurobiology of Disease, Vol 67, Iss , Pp 191-202 (2014)
Microglia, the immune cells of the central nervous system, constantly survey the parenchyma in the healthy brain to maintain homeostasis. When a disturbance, such as cell death, results in ATP release in vivo, microglial processes respond by utilizin
Externí odkaz:
https://doaj.org/article/6fff32c1eda048309711f94e97987885