Multi-omics and clustering analyses reveal the mechanisms underlying unmet needs for patients with lung adenocarcinoma and identify potential therapeutic targets

Autor: Ken Asada, Syuzo Kaneko, Ken Takasawa, Kouya Shiraishi, Norio Shinkai, Yoko Shimada, Satoshi Takahashi, Hidenori Machino, Kazuma Kobayashi, Amina Bolatkan, Masaaki Komatsu, Masayoshi Yamada, Mototaka Miyake, Hirokazu Watanabe, Akiko Tateishi, Takaaki Mizuno, Yu Okubo, Masami Mukai, Tatsuya Yoshida, Yukihiro Yoshida, Hidehito Horinouchi, Shun-Ichi Watanabe, Yuichiro Ohe, Yasushi Yatabe, Takashi Kohno, Ryuji Hamamoto

Publikováno v: Molecular Cancer, Vol 23, Iss 1, Pp 1-9 (2024)

Abstract Background The cancer genome contains several driver mutations. However, in some cases, no known drivers have been identified; these remaining areas of unmet needs, leading to limited progress in cancer therapy. Whole-genome sequencing (WGS)

Externí odkaz: https://doaj.org/article/5ca317bc30aa4ff796701baac2c9a5a6

Quantitative release assessment for beta-lactamase-producing Escherichia coli of dairy origin into vegetables

Autor: Kohei Makita, Dongsheng Zhang, Ayaka Okamura, Akira Fukuda, Natsumi Tokunaga, Tetsuo Asai, Yoko Shimazaki, Masaru Usui

Publikováno v: CABI One Health, Vol 3, Iss 1 (2024)

Abstract Outbreaks of food poisoning associated with vegetables contaminated with Escherichia coli have been reported globally. This study was conducted to assess the probability of releasing beta-lactamase-producing E. coli of dairy farm origin into

Externí odkaz: https://doaj.org/article/8dbcdf1ce41e4a57af01641929122abc

Crystal structures of lysophospholipid-bound MHC class I molecules

Autor: Naoki Mori, Bunzo Mikami, Yoko Shima, Daisuke Morita, Tatsuaki Mizutani, Masahiko Sugita

Publikováno v: J Biol Chem

Newly synthesized major histocompatibility complex (MHC) class I proteins are stabilized in the endoplasmic reticulum (ER) by binding 8–10-mer-long self-peptide antigens that are provided by transporter associated with antigen processing (TAP). The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c11022f9c6866b40dad6d05d891f34b
https://doi.org/10.1074/jbc.ra119.011932

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses

Autor: Kouya Shiraishi, Atsushi Takahashi, Yukihide Momozawa, Yataro Daigo, Syuzo Kaneko, Takahisa Kawaguchi, Hideo Kunitoh, Shingo Matsumoto, Hidehito Horinouchi, Akiteru Goto, Takayuki Honda, Kimihiro Shimizu, Masahiro Torasawa, Daisuke Takayanagi, Motonobu Saito, Akira Saito, Yuichiro Ohe, Shun‐ichi Watanabe, Koichi Goto, Masahiro Tsuboi, Katsuya Tsuchihara, Sadaaki Takata, Tomomi Aoi, Atsushi Takano, Masashi Kobayashi, Yohei Miyagi, Kazumi Tanaka, Hiroyuki Suzuki, Daichi Maeda, Takumi Yamaura, Maiko Matsuda, Yoko Shimada, Takaaki Mizuno, Hiromi Sakamoto, Teruhiko Yoshida, Yasushi Goto, Tatsuya Yoshida, Taiki Yamaji, Makoto Sonobe, Shinichi Toyooka, Kazue Yoneda, Katsuhiro Masago, Fumihiro Tanaka, Megumi Hara, Nobuo Fuse, Satoshi S. Nishizuka, Noriko Motoi, Norie Sawada, Yuichiro Nishida, Kazuki Kumada, Kenji Takeuchi, Kozo Tanno, Yasushi Yatabe, Kuniko Sunami, Tomoyuki Hishida, Yasunari Miyazaki, Hidemi Ito, Mitsuhiro Amemiya, Hirohiko Totsuka, Haruhiko Nakayama, Tomoyuki Yokose, Kazuyoshi Ishigaki, Toshiteru Nagashima, Yoichi Ohtaki, Kazuhiro Imai, Ken Takasawa, Yoshihiro Minamiya, Kazuma Kobayashi, Kenichi Okubo, Kenji Wakai, Atsushi Shimizu, Masayuki Yamamoto, Motoki Iwasaki, Koichi Matsuda, Johji Inazawa, Yuichi Shiraishi, Hiroyoshi Nishikawa, Yoshinori Murakami, Michiaki Kubo, Fumihiko Matsuda, Yoichiro Kamatani, Ryuji Hamamoto, Keitaro Matsuo, Takashi Kohno

Publikováno v: Cancer Communications, Vol 44, Iss 2, Pp 287-293 (2024)

Externí odkaz: https://doaj.org/article/a4b8ea6db19942899046a4b6375483b8

Rare FGFR fusion genes in cervical cancer and transcriptome‐based subgrouping of patients with a poor prognosis

Autor: Kengo Hiranuma, Yuka Asami, Mayumi Kobayashi Kato, Naoya Murakami, Yoko Shimada, Maiko Matsuda, Shu Yazaki, Erisa Fujii, Kazuki Sudo, Ikumi Kuno, Masaaki Komatsu, Ryuji Hamamoto, Hideki Makinoshima, Koji Matsumoto, Mitsuya Ishikawa, Takashi Kohno, Yasuhisa Terao, Atsuo Itakura, Hiroshi Yoshida, Kouya Shiraishi, Tomoyasu Kato

Publikováno v: Cancer Medicine, Vol 12, Iss 17, Pp 17835-17848 (2023)

Abstract Background Although cervical cancer is often characterized as preventable, its incidence continues to increase in low‐ and middle‐income countries, underscoring the need to develop novel therapeutics for this disease.This study assessed

Externí odkaz: https://doaj.org/article/16a7ff7c704942b4a949ca70b9e89c21