Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Yoko K Takada"'
Autor:
Dora Maria Cedano Prieto, Yushen Cheng, Chih-Chieh Chang, Jessica Yu, Yoko K Takada, Yoshikazu Takada
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184285 (2017)
We have reported that integrins crosstalk with growth factors through direct binding to growth factors (e.g., fibroblast growth factor-1, insulin-like growth factor 1 (IGF1), neuregulin-1, fractalkine) and subsequent ternary complex formation with co
Externí odkaz:
https://doaj.org/article/8ba0955228b34dd991183a8b416766e6
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93738 (2014)
The prototypic acute phase reactant C-reactive protein (CRP) is not only a marker but also a potential contributor to inflammatory diseases. CRP exists as the circulating native, pentameric CRP (pCRP) and the monomeric isoform (mCRP), formed as a res
Externí odkaz:
https://doaj.org/article/bfcabcb48a6c4f91baa3484528c9af87
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96372 (2014)
The chemokine domain of fractalkine (FKN-CD) binds to the classical RGD-binding site of αvβ3 and that the resulting ternary complex formation (integrin-FKN-CX3CR1) is critical for CX3CR1 signaling and FKN-induced integrin activation. However, only
Externí odkaz:
https://doaj.org/article/e0c0ba5fe275403ab5116c6158b1add3
Autor:
Seiji Mori, Vu Tran, Kyoko Nishikawa, Teruya Kaneda, Yoshinosuke Hamada, Naomasa Kawaguchi, Masaaki Fujita, Jun Saegusa, Yoko K Takada, Nariaki Matsuura, Min Zhao, Yoshikazu Takada
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57927 (2013)
Fibroblast growth factor-1 (FGF1) and FGF2 play a critical role in angiogenesis, a formation of new blood vessels from existing blood vessels. Integrins are critically involved in FGF signaling through crosstalk. We previously reported that FGF1 dire
Externí odkaz:
https://doaj.org/article/e4e462e69e074467bf74bcf33a683f77
Autor:
Satoshi Yamaji, Jun Saegusa, Katsuaki Ieguchi, Masaaki Fujita, Seiji Mori, Yoko K Takada, Yoshikazu Takada
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10273 (2010)
Crosstalk between integrins and FGF receptors has been implicated in FGF signaling, but the specifics of the crosstalk are unclear. We recently discovered that 1) FGF1 directly binds to integrin alphavbeta3, 2) the integrin-binding site and FGF recep
Externí odkaz:
https://doaj.org/article/990e15d6d3164038a0986ff4bb88ecfa
Autor:
Yoko K. Takada, Jessica Yu, Xiaojin Ye, Chun-Yi Wu, Brunie H. Felding, Masaaki Fujita, Yoshikazu Takada
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
VEGF-A is a key cytokine in tumor angiogenesis and a major therapeutic target for cancer. VEGF165 is the predominant isoform of VEGF-A, and it is the most potent angiogenesis stimulant. VEGFR2/KDR domains 2 and 3 (D2D3) bind to the N-terminal domain
Externí odkaz:
https://doaj.org/article/e866fcf88a0e4e8b8ea28785ffe23f88
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 888 (2024)
Several inflammatory cytokines bind to the allosteric site (site 2) and allosterically activate integrins. Site 2 is also a binding site for 25-hydroxycholesterol, an inflammatory lipid mediator, and is involved in inflammatory signaling (e.g., TNF a
Externí odkaz:
https://doaj.org/article/1237d8b786024a14a3ab67e95d2d056a
Autor:
Chih-Chieh Chang, Yoko K. Takada, Chao-Wen Cheng, Yukina Maekawa, Seiji Mori, Yoshikazu Takada
Publikováno v:
Cells, Vol 13, Iss 4, p 307 (2024)
FGF9 is a potent mitogen and survival factor, but FGF9 protein levels are generally low and restricted to a few adult organs. Aberrant expression of FGF9 usually results in cancer. However, the mechanism of FGF9 action has not been fully established.
Externí odkaz:
https://doaj.org/article/614fb72014324302bdc8aa35442eed17
Publikováno v:
Cells, Vol 12, Iss 18, p 2265 (2023)
Integrins were originally identified as receptors for extracellular matrix (ECM) and cell-surface molecules (e.g., VCAM-1 and ICAM-1). Later, we discovered that many soluble growth factors/cytokines bind to integrins and play a critical role in growt
Externí odkaz:
https://doaj.org/article/9e7e8bf784504209badecf26d7c1fba9
Publikováno v:
Cells, Vol 12, Iss 15, p 1977 (2023)
CD40L is expressed in activated T cells, and it plays a major role in immune response and is a major therapeutic target for inflammation. High IgM syndrome type 1 (HIGM1) is a congenital functional defect in CD40L/CD40 signaling due to defective CD40
Externí odkaz:
https://doaj.org/article/575bdfa973794c68b30f549c3a8540ed