Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Yoko Irukayama‐Tomobe"'
Autor:
Hikari Yamamoto, Yasuyuki Nagumo, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Yukiko Namekawa, Tsuyoshi Nemoto, Hiromu Tanaka, Genki Takahashi, Akihisa Tokuda, Tsuyoshi Saitoh, Hiroshi Nagase, Hiromasa Funato, Masashi Yanagisawa
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271901 (2022)
Acquired loss of hypothalamic orexin (hypocretin)-producing neurons causes the chronic sleep disorder narcolepsy-cataplexy. Orexin replacement therapy using orexin receptor agonists is expected as a mechanistic treatment for narcolepsy. Orexins act o
Externí odkaz:
https://doaj.org/article/eca4900ef18e47168c9b01a29a3ececa
Autor:
Yasuhiro Ogawa, Yoko Irukayama-Tomobe, Nobuyuki Murakoshi, Maiko Kiyama, Yui Ishikawa, Naoto Hosokawa, Hiromu Tominaga, Shuntaro Uchida, Saki Kimura, Mika Kanuka, Miho Morita, Michito Hamada, Satoru Takahashi, Yu Hayashi, Masashi Yanagisawa
Publikováno v:
eLife, Vol 5 (2016)
Sepsis is a systemic inflammatory response to infection, accounting for the most common cause of death in intensive care units. Here, we report that peripheral administration of the hypothalamic neuropeptide orexin improves the survival of mice with
Externí odkaz:
https://doaj.org/article/b97c3e7543c743b6abdc7a2ccd886b22
Autor:
Noriya Watanabe, Mari Wada, Yoko Irukayama-Tomobe, Yousuke Ogata, Natsuko Tsujino, Mika Suzuki, Naoki Furutani, Takeshi Sakurai, Miyuki Yamamoto
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35390 (2012)
Neuropeptide B/W receptor-1 (NPBWR1) is expressed in discrete brain regions in rodents and humans, with particularly strong expression in the limbic system, including the central nucleus of the amygdala. Recently, Nagata-Kuroiwa et al. reported that
Externí odkaz:
https://doaj.org/article/356e45d2c1dc4143ad75aae6ccbfbe81
Autor:
Tsuyoshi Nemoto, Yoko Irukayama‐Tomobe, Yuki Hirose, Hiromu Tanaka, Genki Takahashi, Satoshi Takahashi, Masashi Yanagisawa, Takashi Kanbayashi
Publikováno v:
Journal of sleep researchREFERENCES. 31(5)
Despite extensive evidence on the organ protective effects of sevoflurane, its effect on disturbed sleep remains unclear. We hypothesised that sevoflurane preconditioning positively impacts disturbed sleep caused by systemic inflammation. A prospecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8883aae9373d01a6fd5764204ae9b5
https://pubmed.ncbi.nlm.nih.gov/35170121
https://pubmed.ncbi.nlm.nih.gov/35170121
Autor:
Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
Publikováno v:
Bioorganicmedicinal chemistry letters. 60
A novel series of 1-amino-tetralin derivatives were designed and synthesized based on the putative binding mode of the naphthalene-type orexin receptor agonist 5 and their agonist activities against orexin receptors were evaluated. The introduction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aae6454ae5d938fb321fbcadcbfd765
https://pubmed.ncbi.nlm.nih.gov/35051577
https://pubmed.ncbi.nlm.nih.gov/35051577
Autor:
Yukiko Ishikawa, Yoko Irukayama-Tomobe, Tsubasa Hino, Naoshi Yamamoto, Hiroshi Nagase, Yasuyuki Nagumo, Masashi Yanagisawa, Noriki Kutsumura, Tsuyoshi Saitoh, Ryuji Tanimura
Publikováno v:
Bioorganicmedicinal chemistry letters. 59
A novel series of naphthalene derivatives were designed and synthesized based on the strategy focusing on the restriction of the flexible bond rotation of OX2R selective agonist YNT-185 (1) and their agonist activities against orexin receptors were e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a156a52c16b33607fe4372900cffff08
https://pubmed.ncbi.nlm.nih.gov/35007725
https://pubmed.ncbi.nlm.nih.gov/35007725
Autor:
Tsuyoshi Saitoh, Mao Amezawa, Jumpei Horiuchi, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Ryuichiro Ohshita, Akihisa Tokuda, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Emi Hasegawa, Takeshi Sakurai, Yasuo Uchida, Tetsu Sato, Hiroaki Gouda, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
Structurally diverse small compounds are utilized to obtain hit compounds that have suitable pharmacophores in appropriate three-dimensional conformations for the target drug receptors. We have focused on the 1,3,5-trioxazatriquinane skeleton, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0571529b5d14b8ad54e10a712a84a9
https://doi.org/10.26434/chemrxiv-2021-08md1
https://doi.org/10.26434/chemrxiv-2021-08md1
Autor:
Tsuyoshi Nemoto, Yoko Irukayama-Tomobe, Yuki Hirose, Satoshi Takahashi, Genki Takahashi, Hiromu Tanaka, Masashi Yanagisawa, Takashi Kanbayashi
Publikováno v:
Sleep. 45:A66-A67
Introduction Anesthesia and sleep partially share neural circuits, yet little is known regarding the effect of anesthetics on sleep. Anesthetic agents exhibit a variety of biological effects concomitant with anesthesia. Sevoflurane, one of the wildly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e09f5285ae22d95a02af45919449d90
https://doi.org/10.1093/sleep/zsac079.144
https://doi.org/10.1093/sleep/zsac079.144
Autor:
Daichi Hayakawa, Noriki Kutsumura, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Tsuyoshi Saitoh, Naoshi Yamamoto, Takahiro Okada, Hiroaki Gouda, Sayaka Ohrui, Masashi Yanagisawa, Yurie Watanabe, Hiroshi Nagase, Yasuyuki Nagumo, Yasuhiro Ogawa
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:1747-1758
Morphinan derivatives lacking the 4,5-epoxy ring were synthesized to examine the participation of the 14-OH group, the 3-OMe group, and the aromaticity of the A-ring in the activity and selectivity for the orexin 1 receptor (OX1R). The assay results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb2366a4c1289deaee4efa1703d789b
https://doi.org/10.1016/j.bmc.2019.03.010
https://doi.org/10.1016/j.bmc.2019.03.010
Autor:
Koki Katoh, Noriki Kutsumura, Naoshi Yamamoto, Yasuyuki Nagumo, Tsuyoshi Saitoh, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 59:128550
The five-membered D-ring nalfurafine (d-nor-nalfurafine) derivatives with a 16-sulfonamide group were synthesized. Conversion of the 16-cyclopropylmethyl group to the 16-benzenesulfonamide group in the d-nor-nalfurafine derivatives drastically improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321169fda7dc769403e609cc87ebdd81
https://doi.org/10.1016/j.bmcl.2022.128550
https://doi.org/10.1016/j.bmcl.2022.128550