Zobrazeno 1 - 10 of 128 pro vyhledávání: '"Yoko Hirabayashi"'
1
Akademický článek
Age-related exacerbation of hematopoietic organ damage induced by systemic hyper-inflammation in senescence-accelerated mice
Autor: Tomonori Harada, Isao Tsuboi, Hirotsugu Hino, Miyuki Yuda, Yoko Hirabayashi, Shuichi Hirai, Shin Aizawa
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic hyper-inflammatory disorder. The mortality of HLH is higher in the elderly than in young adults. Senescence-accelerated mice (SAMP1/TA-1) exhibit characteristic accelera
Externí odkaz: https://doaj.org/article/035b3c59f87d46d493245ef75060b768
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2
Akademický článek
Novel hepatotoxicity biomarkers of extracellular vesicle (EV)-associated miRNAs induced by CCl4
Autor: Ryuichi Ono, Yusuke Yoshioka, Yusuke Furukawa, Mie Naruse, Makiko Kuwagata, Takahiro Ochiya, Satoshi Kitajima, Yoko Hirabayashi
Publikováno v: Toxicology Reports, Vol 7, Iss , Pp 685-692 (2020)
Recent findings have revealed that extracellular vesicles (EVs) are secreted from cells and circulate in the blood. EVs are classified as exosomes (40−100 nm), microvesicles (50−1,000 nm) or apoptotic bodies (500−2,000 nm). EVs contain mRNAs, m
Externí odkaz: https://doaj.org/article/72657d68a57f4d1dba82a8c4c230ad96
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3
Akademický článek
Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis
Autor: Isao Tsuboi, Tomonori Harada, Yoko Hirabayashi, Shin Aizawa
Publikováno v: Haematologica, Vol 104, Iss 10 (2019)
Hemophagocytic lymphohistiocytosis is a life-threatening systemic hyperinflammatory disorder with primary and secondary forms. Primary hemophagocytic lymphohistiocytosis is associated with inherited defects in various genes that affect the immunologi
Externí odkaz: https://doaj.org/article/585780087b1842d382cfd8e7af1542d6
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4
Akademický článek
LTRs of Endogenous Retroviruses as a Source of Tbx6 Binding Sites
Autor: Yukuto Yasuhiko, Yoko Hirabayashi, Ryuichi Ono
Publikováno v: Frontiers in Chemistry, Vol 5 (2017)
Retrotransposons are abundant in mammalian genomes and can modulate the gene expression of surrounding genes by disrupting endogenous binding sites for transcription factors (TFs) or providing novel TFs binding sites within retrotransposon sequences.
Externí odkaz: https://doaj.org/article/a67a59c32d134c5a8266b0db79cd98e8
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5
Akademický článek
A 90-day repeated oral dose toxicity study of p-cymene in rats.
Autor: Makiko Kuwagata, Yuko Doi, Hirokatsu Saito, Mariko Tsurumoto, Toshime Igarashi, Takuya Nishimura, Yuhji Taquahashi, Yoko Hirabayashi, Satoshi Kitajima
Publikováno v: Fundamental Toxicological Sciences; 2024, Vol. 11 Issue 4, p169-181, 13p
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7
Imbalanced M1 and M2 Macrophage Polarization in Bone Marrow Provokes Impairment of the Hematopoietic Microenvironment in a Mouse Model of Hemophagocytic Lymphohistiocytosis
Autor: Miyuki Yuda, Shin Aizawa, Isao Tsuboi, Yoko Hirabayashi, Tomonori Harada, Hirotsugu Hino, Shuichi Hirai
Publikováno v: Biological and Pharmaceutical Bulletin. 45:1602-1608
Lipopolysaccharide (LPS) treatment induced hemophagocytic lymphohistiocytosis in senescence-accelerated mice (SAMP1/TA-1), but not in senescence-resistant control mice (SAMR1). SAMP1/TA-1 treated with LPS exhibited functional impairment of the hemato
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717db705cf91e2e6735898c1f2cd612f
https://doi.org/10.1248/bpb.b22-00108
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