Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yoko Ejiri"'
Autor:
Takanori Takebe, Keisuke Sekine, Masaki Kimura, Emi Yoshizawa, Satoru Ayano, Masaru Koido, Shizuka Funayama, Noriko Nakanishi, Tomoko Hisai, Tatsuya Kobayashi, Toshiharu Kasai, Rina Kitada, Akira Mori, Hiroaki Ayabe, Yoko Ejiri, Naoki Amimoto, Yosuke Yamazaki, Shimpei Ogawa, Momotaro Ishikawa, Yasujiro Kiyota, Yasuhiko Sato, Kohei Nozawa, Satoshi Okamoto, Yasuharu Ueno, Hideki Taniguchi
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2661-2670 (2017)
Summary: Organoid technology provides a revolutionary paradigm toward therapy but has yet to be applied in humans, mainly because of reproducibility and scalability challenges. Here, we overcome these limitations by evolving a scalable organ bud prod
Externí odkaz:
https://doaj.org/article/a82cbaeac6e0480a92f03b989a1e317e
Autor:
Shimpei Ogawa, Yasuhiko Sato, Hiroaki Ayabe, Masaru Koido, Akira Mori, Emi Yoshizawa, Yoko Ejiri, Keisuke Sekine, Shizuka Funayama, Kohei Nozawa, Momotaro Ishikawa, Tatsuya Kobayashi, Toshiharu Kasai, Rina Kitada, Satoshi Okamoto, Noriko Nakanishi, Tomoko Hisai, Yasujiro Kiyota, Yosuke Yamazaki, Masaki Kimura, Satoru Ayano, Takanori Takebe, Naoki Amimoto, Yasuharu Ueno, Hideki Taniguchi
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2661-2670 (2017)
Summary: Organoid technology provides a revolutionary paradigm toward therapy but has yet to be applied in humans, mainly because of reproducibility and scalability challenges. Here, we overcome these limitations by evolving a scalable organ bud prod
Publikováno v:
Biochemical and biophysical research communications. 509(1)
Cytochrome P450 (CYP) 3A4 plays an important role in drug metabolism. Although transcriptional regulation of CYP3A expression by chemicals has been comprehensively studied, its post-translational regulation is not fully understood. We previously repo
Autor:
Kaoru Kobayashi, Hanaka Mimura, Masaya Hosoda, Yoko Ejiri, Mari Hashimoto, Kan Chiba, Linxiaoqing Xu
Publikováno v:
Drug Metabolism and Pharmacokinetics. 30:105-110
The expression of hepatic cytochrome P450 (CYP) enzymes is altered under pathological conditions with increased levels of cytokines. In this study, we analyzed the effects of cytokines (interleukin [IL]-1β, IL-6 and tumor necrosis factor α) on the
Publikováno v:
Biochemical and biophysical research communications. 486(3)
Cytochrome P450 (CYP) 3A subfamily members are known to metabolize various types of drugs, highlighting the importance of understanding drug-drug interactions (DDI) depending on CYP3A induction or inhibition. While transcriptional regulation of CYP3A
Publikováno v:
Scientific Reports
Acetaminophen (APAP) is extensively used as an analgesic and antipyretic drug. APAP is partly metabolized to N-acetyl-p-benzoquinone imine, a reactive metabolite, by cytochrome P450 (CYP) 1A2, 2E1 and 3A4. Some reports have indicated that CYP3A prote
Publikováno v:
The Journal of toxicological sciences. 41(1)
Drug-induced phospholipidosis (PLD) is one of the adverse reactions to treatment with cationic amphiphilic drugs. Recently, simple and reliable evaluation methods for PLD have been reported. However, the predictive power of these methods for in vivo
Publikováno v:
Cancer Research. 78:888-888
In the last few years, one of the most innovative areas of cancer research has been immuno-oncology where significant advancements have been seen, particularly, in the use of monoclonal antibodies to treat cancers. The regulation of immune-mediated k
Autor:
Mieko Hagi, Shinsaku Naito, Yoko Ejiri, Masuhiro Nishimura, Shizuo Narimatsu, Toru Horie, Sanae Kishimoto
Publikováno v:
Drug Metabolism and Pharmacokinetics. 25:236-242
We evaluated a novel primary three-dimensional culture system for human hepatocytes using micro-space plates. The functional activity of human hepatocytes in primary culture was determined by measuring albumin secretion from hepatocytes to medium and
Autor:
Eiji Mizuta, Naoya Matsumoto, Hirotomi Chou, Yoshihisa Suzuki, Sadako Kuno, Mari Dezawa, Yasushi Iwashita, Yoko Ejiri, Kazuya Kataoka, Chizuka Ide, Namiko Ishikawa, Masayoshi Ohta, Toru Noda
Publikováno v:
Experimental Neurology. 187:266-278
The effects of bone marrow stromal cells (BMSCs) on the repair of injured spinal cord and on the behavioral improvement were studied in the rat. The spinal cord was injured by contusion using a weight-drop at the level of T8-9, and the BMSCs from the