Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Yoko Deai"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 44:128115
Kynurenine monooxygenase (KMO) is expected to be a good drug target to treat Huntington's disease (HD). This study presents the structure-activity relationship of pyridazine derivatives to find novel KMO inhibitors. The most promising compound 14 res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375ddeb5768db8eed4d7c0bd60b226ef
https://doi.org/10.1016/j.bmcl.2021.128115
https://doi.org/10.1016/j.bmcl.2021.128115
Autor:
Mari Miyajima, Mika Endo, Yoko Deai, Momoe Kassai, Hitoshi Suda, Masahiro Yahata, Yoshiaki Isobe, Hidenori Kimura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 33:127753
Huntington's disease (HD) is one of the serious neurodegenerative diseases and no disease modifiers are available to date. The correction of unbalanced kynurenine pathway metabolites may be useful to treat disease progression and kynurenine monooxyge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dfaa8c8e5fb195414e5d61a2dbd507
https://doi.org/10.1016/j.bmcl.2020.127753
https://doi.org/10.1016/j.bmcl.2020.127753
Autor:
Takayoshi Kinoshita, Hideyuki Muramatsu, Motoo Kobayashi, Michizane Hashimoto, Seiji Yoshimura, Yoko Deai, Hidenori Ohki, Kazuki Okada, Satoshi Sasamura, Yukiko Yamagishi
Publikováno v:
The Journal of Antibiotics. 68:511-520
FR901459, a product of the fungus Stachybotrys chartarum No. 19392, is a derivative of cyclosporin A (CsA) and a powerful immunosuppressant that binds cyclophilin. Recently, it was reported that CsA was effective against hepatitis C virus (HCV). Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22bc32e5ecb487bcf0c1e2fd4ab64393
https://doi.org/10.1038/ja.2015.19
https://doi.org/10.1038/ja.2015.19