Zobrazeno 1 - 10 of 113 pro vyhledávání: '"Yoko, Yoshikawa"'
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Akademický článek
Phospholipase Cε plays a crucial role in neutrophilic inflammation accompanying acute lung injury through augmentation of CXC chemokine production from alveolar epithelial cells
Autor: Kanoko Umezawa, Tatsuya Nagano, Kazuyuki Kobayashi, Ryota Dokuni, Masahiro Katsurada, Masatsugu Yamamoto, Yoko Yoshikawa, Tohru Kataoka, Yoshihiro Nishimura
Publikováno v: Respiratory Research, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background We have shown that phospholipase Cε (PLCε), an effector of Ras and Rap1 small GTPases, plays pivotal roles in inflammation and inflammation-associated carcinogenesis by augmenting proinflammatory cytokine production from epithel
Externí odkaz: https://doaj.org/article/f038243915e8423fb75813a763b7a949
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2
Development e-portfolio system' ENISHI' to support self-motivated growth of researchers
Autor: Miki, Oeki, Minae, Ago, Teruko, Ishibashi, Yoko, Yoshikawa, Mikiko, Sato, Shoko, Takahashi, Masako, Okayasu, Takanobu, Goto, Sashiko, Suto, Yusuke, Ota
Publikováno v: 島根県立大学出雲キャンパス紀要. 18:48-54
研究者が自己評価をすることにより，キャリアデザインを具体化・可視化するシステムであるe ポートフォリオシステム“ENISHI”を開発したので紹介する。“ENISHI”は，個々の研究者が
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::84b22f0085b5f910a388e6d329b23b54
http://id.nii.ac.jp/1377/00002019/
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4
Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring
Autor: Shigeyuki Matsumoto, Chiemi Tsuda, Masahiro Neya, Yuki Hayashi, Yoko Yoshikawa, Tohru Kataoka, Toshiki Hiraga, Fumi Shima, Mitsugu Araki
Publikováno v: Biochemistry. 57(36):5350-5358
The ras oncogene products (H-Ras, K-Ras, and N-Ras) have been regarded as some of the most promising targets for anticancer drug discovery because their activating mutations are frequently found in human cancers. Nonetheless, molecular targeted thera
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7321e8308db1824df508bda8608f6e9a
http://www.lib.kobe-u.ac.jp/handle_kernel/90005432
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5
Collaborative Research among Industry-Academia Cooperation Projects in The University of Shimane, Izumo Campus
Autor: Kazuya, YAMASHITA, Sayaka, FUJITA, Yoko, YOSHIKAWA
Publikováno v: 島根県立大学出雲キャンパス紀要. 13:153-157
産学連携商品の開発は各大学が行っているが、実際に商品化することは難しい。島根県立大学出雲キャンパスとして現在まで行ってきた開発商品を紹介し、その問題点を検討した。産学
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::7ad97d9e62a27f3fb8fcee92623ea1d2
http://id.nii.ac.jp/1377/00001764/
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6
Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1α pathway
Autor: Tohru Kataoka, Ichiro Kato, Fumi Shima, Yoshihisa Takahashi, Yoko Yoshikawa, Osamu Takano
Publikováno v: Cancer Letters. 410:82-91
Metastasis stands as the major obstacle for the survival from cancers. Nonetheless most existing anti-cancer drugs inhibit only cell proliferation, and discovery of agents having both anti-proliferative and anti-metastatic properties would be more be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7706c328833721894f35352e5f107f
https://hdl.handle.net/20.500.14094/90004440
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Rapgef2, a guanine nucleotide exchange factor for Rap1 small GTPases, plays a crucial role in adherence junction (AJ) formation in radial glial cells through ERK-mediated upregulation of the AJ-constituent protein expression
Autor: Tohru Kataoka, Maged Ibrahim Farag, Yoko Yoshikawa, Kazuhiro Maeta
Publikováno v: Biochemical and Biophysical Research Communications. 493:139-145
Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap1, characterized by possession of the Ras/Rap-associating domains and implicated in the etiology of schizophrenia. We previously found that dorsal telencephalon-spec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0959534b7e5f8b0e23ecf4ecf224355b
https://doi.org/10.1016/j.bbrc.2017.09.062
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Structural basis for intramolecular interaction of post-translationally modified H-Ras.GTP prepared by protein ligation
Autor: Yoko Yoshikawa, Eiichi Mizohata, Shigeyuki Matsumoto, Tohru Kataoka, Hironori Edamatsu, Haoliang Ke, Takashi Kumasaka, Chiemi Tsuda, Haruka Taniguchi-Tamura, Ryo Miyamoto, Yosuke Murashima
Publikováno v: FEBS Letters. 591(16):2470-2481
Ras undergoes post-translational modifications including farnesylation, proteolysis, and carboxymethylation at the C terminus, which are necessary for membrane recruitment and effector recognition. Full activation of c-Raf-1 requires cooperative inte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305f311f4762da954cadbe7b7afe4afe
https://hdl.handle.net/20.500.14094/90004244
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10
Current status of the development of Ras inhibitors
Autor: Yoko Yoshikawa, Takashi Kawamura, Shigeyuki Matsumoto, Tohru Kataoka, Masayuki Isa, Fumi Shima
Publikováno v: Journal of Biochemistry. 158:91-99
Despite the importance of ras as driver genes in many cancers, clinically effective anti-cancer drugs targeting their products, Ras, have been unavailable so far, which was in part ascribable to the apparently 'undruggable' nature of their tertiary s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bcd5f32b1efa7cdd279b027abae806
https://doi.org/10.1093/jb/mvv060
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