Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Yoji Tsugawa"'
Autor:
Yoji Tsugawa, Kentaro Furukawa, Tomoko Ise, Masahiro Takayama, Takeshi Ota, Takayuki Kuroda, Shinya Shano, Takashi Hashimoto, Haruyo Konishi, Takeshi Ishihara, Masaaki Sato, Haruhiko Kamada, Keita Fukao, Takao Shishido, Mai Yoshikawa, Tatsuya Takahashi, Satoshi Nagata
Publikováno v:
PLoS ONE, Vol 19, Iss 12, p e0300297 (2024)
The SARS-CoV-2 pandemic alerted the potential for significant harm due to future cross-species transmission of various animal coronaviruses to human. There is a significant need of antibody-based drugs to treat patients infected with previously unsee
Externí odkaz:
https://doaj.org/article/12dad7a754c140d7abd11d6c4992273c
Autor:
Jaeyong Cho, Atsushi Miyagawa, Kazuki Yamaguchi, Wakana Abe, Yoji Tsugawa, Hatsuo Yamamura, Takeshi Imai
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Insulin secretion is regulated in multiple steps, and one of the main steps is in the endoplasmic reticulum (ER). Here, we show that UDP-glucose induces proinsulin ubiquitination by cereblon, and uridine binds and competes for proinsulin deg
Externí odkaz:
https://doaj.org/article/088902a20e5e4c2fa79745e5ca334525
Autor:
Yuki Hattori, Yu Naito, Yoji Tsugawa, Shigenori Nonaka, Hiroaki Wake, Takashi Nagasawa, Ayano Kawaguchi, Takaki Miyata
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Microglia temporarily disappear from the cortical plate in the midembryonic stage. This study demonstrated that microglial transient absence from the cortical plate is required for postmigratory neurons to appropriately fine-tune the expression of mo
Externí odkaz:
https://doaj.org/article/228777daf6424d718afb037c8a743819
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89869 (2014)
Several viruses are known to infect human liver and cause the hepatitis, but the interferon (IFN) response, a first-line defense against viral infection, of virus-infected hepatocytes is not clearly defined yet. We investigated innate immune system a
Externí odkaz:
https://doaj.org/article/9e31fc45da3c4ea5aee66c0e17dc539d
Autor:
Yusuke Nishida, Takaki Miyata, Haruka Itoh, Yuki Hattori, Akiyoshi Uemura, Yoji Tsugawa, Kaori Kurata
Publikováno v:
J Neurosci
Multifaceted microglial functions in the developing brain, such as promoting the differentiation of neural progenitors and contributing to the positioning and survival of neurons, have been progressively revealed. Although previous studies have noted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451700477fa2181a0985623e5f7228d4
https://doi.org/10.1523/jneurosci.1201-21.2021
https://doi.org/10.1523/jneurosci.1201-21.2021
Publikováno v:
Biochemical and biophysical research communications. 615
Arginine releases proinsulin from binding to UGGT1 in the endoplasmic reticulum (ER). PSIPRED analysis showed that the arginine/proinsulin binding domain (A/PBD) in the C-terminal region of UGGT1 forms a disordered region, which is flexible and outsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589f0e8117c9fddd628b6076a238a64f
https://pubmed.ncbi.nlm.nih.gov/35613513
https://pubmed.ncbi.nlm.nih.gov/35613513
Autor:
Jaeyong Cho, Yukio Horikawa, Masato Yonamine, Yoji Tsugawa, Mayumi Enya, Hiroaki Masuzaki, Daisuke Yabe, Takeshi Imai
Arginine releases proinsulin from binding to UGGT1 in the endoplasmic reticulum (ER). PSIPRED analysis showed that the arginine/proinsulin binding domain (A/PBD) in the C-terminal region of UGGT1 forms a disordered region, which is flexible and outsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edfef35362c15ff596532977140d7b4f
https://doi.org/10.21203/rs.3.rs-1371648/v1
https://doi.org/10.21203/rs.3.rs-1371648/v1
Publikováno v:
Biochem Biophys Res Commun
The liver increases its size during pregnancy to adapt to metabolic demand associated with pregnancy. Our previous study showed that proliferation of maternal hepatocytes are increased during pregnancy in mice and that estradiol (E2) is one of the ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30602ce9592501d6a96d11e6fbb8f032
https://pubmed.ncbi.nlm.nih.gov/34597993
https://pubmed.ncbi.nlm.nih.gov/34597993
Publikováno v:
Clinical and Experimental Gastroenterology. 12:331-336
Background: We previously demonstrated that liver resection triggers estradiol production, which, in turn, induces the proliferation of hepatocytes to promote liver regeneration in mice. In this study, we demonstrated estradiol-induced estrogen recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3ce8fe1e1a29af95eeb7c914c382cef
https://doi.org/10.2147/ceg.s214196
https://doi.org/10.2147/ceg.s214196
Publikováno v:
Biochemical and Biophysical Research Communications. 511:592-596
Partial hepatectomy (PH) induces estradiol production, and then hepatocyte proliferation. Estradiol may play a role in triggering hepatocyte proliferation after PH. In this study, estradiol was injected to the Estrogen Receptor alpha (ERα) or ERβ K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b61c3875f0206b9ba8e124684e122d
https://doi.org/10.1016/j.bbrc.2019.02.119
https://doi.org/10.1016/j.bbrc.2019.02.119