Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Yoji Kyotani"'
Autor:
Akihiko Tanaka, Katsuki Wakayama, Yosuke Fukuda, Shin Ohta, Tetsuya Homma, Koichi Ando, Yuji Nishihara, Ryuichi Nakano, Jing Zhao, Yuki Suzuki, Yoji Kyotani, Hisakazu Yano, Kei Kasahara, Kuei-Pin Chung, Hironori Sagara, Masanori Yoshizumi, Kiichi Nakahira
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Cell-free DNA (cfDNA) is released from injured cells and aggravates inflammation. Patients with coronavirus disease (COVID-19) often develop pneumonia and respiratory failure, and require oxygen therapy (OT), including mechanical ventilation
Externí odkaz:
https://doaj.org/article/610cf4dde8754ece946144192f058d66
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Neuroleptic malignant syndrome (NMS) is a rare but serious and sometimes fatal complication in patients taking antipsychotic drugs, and its underlying mechanism still remains unclear. The pharmacotherapy for psychotic disorders is complicate
Externí odkaz:
https://doaj.org/article/e32b91af9a78486da6653911fec02a56
Autor:
Yoji Kyotani, Asako Itaya‐Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto‐Tsuchida, Mai Makino, Shin Takasawa, Masanori Yoshizumi
Publikováno v:
FEBS Open Bio, Vol 8, Iss 5, Pp 868-876 (2018)
Patients with obstructive sleep apnea (OSA) experience repetitive episodes of desaturation and resaturation of blood oxygen (known as intermittent hypoxia or IH), during sleep. We showed previously that IH induced excessive proliferation of rat vascu
Externí odkaz:
https://doaj.org/article/6beaa8a64bf04daebb6eb0eaccca6605
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8660 (2020)
Aortic dissection and aneurysm are associated with abnormal hemodynamic loads originating from hypertension. Our previous study demonstrated that cyclic mechanical stretch (CMS, mimicked hypertension) caused the death of rat aortic smooth muscle cell
Externí odkaz:
https://doaj.org/article/f58f609686134cc6bcbaa907418ed2e1
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 1, Pp 69-74 (2015)
Acute aortic dissection (AAD) is a life-threating disease; however, there is almost no effective pharmacotherapy for it. An increase in c-Jun N-terminal kinase (JNK) phosphorylation and smooth muscle cell (SMC) apoptosis is observed tissues in patien
Externí odkaz:
https://doaj.org/article/ed8b35b14e2e4997a50c12d0a93ef0e6
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2706 (2019)
Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia (IH) and is a risk factor for cardiovascular diseases (e.g., atherosclerosis) and chronic inflammatory diseases (CID). The excessive proliferation of vascular smooth muscle cells
Externí odkaz:
https://doaj.org/article/646ee69a2ee54e348dc7f04bdb0a08a8
Autor:
Masanori Yoshizumi, Yoji Kyotani, Jing Zhao, Kosuke Nagayama, Satoyasu Ito, Yuichi Tsuji, Kentaro Ozawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 4, Pp 259-263 (2012)
Big mitogen-activated protein kinase 1 (BMK1), also known as extracellular signal-regulated kinase 5 (ERK5), is a newly identified member of the mitogen-activated protein (MAP) kinase family. BMK1 has been reported to be sensitive to various neuro-hu
Externí odkaz:
https://doaj.org/article/760e956be3204d30ae9278e2d97de566
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 2, Pp 173-180 (2011)
Abstract.: Oxidative stress is considered a major mediator of arteriosclerosis. In vascular smooth muscle cells, oxidative stress–induced cell death (including apoptosis) is probably related to arterial calcification in arteriosclerosis. Big mitoge
Externí odkaz:
https://doaj.org/article/56f79ce2d15f45b5af72dc59461c25f4
Autor:
Yoji Kyotani, Jing Zhao, Sayuko Tomita, Hitoshi Nakayama, Minoru Isosaki, Masayuki Uno, Masanori Yoshizumi
Publikováno v:
Journal of Pharmacological Sciences, Vol 113, Iss 2, Pp 161-168 (2010)
Clinical studies have shown that angiotensin-receptor blockers (ARBs) reduce the risk of cardiovascular diseases in hypertensive patients. It is assumed that the reduction of the risk by ARBs may be attributed in part to the inhibition of angiotensin
Externí odkaz:
https://doaj.org/article/5b04eed52f2e4fb083a3b8e2d0727364
Autor:
Kosuke Nagayama, Yoji Kyotani, Jing Zhao, Satoyasu Ito, Kentaro Ozawa, Francesco A Bolstad, Masanori Yoshizumi
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137960 (2015)
Angiotensin II (Ang II) is a main pathophysiological culprit peptide for hypertension and atherosclerosis by causing vascular smooth muscle cell (VSMC) proliferation and migration. Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist, is cur
Externí odkaz:
https://doaj.org/article/20501c20fbcd42c3bea4e3acb0b08b89