Výsledky vyhledávání - "Yoichiro Nihashi"

Surface Plasmon Resonance Assay of Binding Properties of Antisense Oligonucleotides to Serum Albumins and Lipoproteins

Autor: Ayahisa Watanabe, Hiroshi Kamimori, Reina Onishi, Mitsuaki Sekiguchi, Akira Kugimiya, Yoichiro Nihashi, Hiroki Kinouchi, Mado Nakajima

Publikováno v: Analytical Sciences. 31:1255-1260

In the present study, we developed an assay to evaluate the kinetic binding properties of the unconjugated antisense oligonucleotide (ASO) and lipophilic and hydrophilic ligands conjugated ASOs to mouse and human serum albumin, and lipoproteins using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4a2588b92b9694e0c3bf667a6d9c92
https://doi.org/10.2116/analsci.31.1255

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A Facile Method for Preferential Modification of the N-Terminal Amino Group of Peptides Using Triazine-Based Coupling Reagents

Autor: Hironori Juichi, Hisashi Miyagawa, Atsushi Kitanaka, Yoichiro Nihashi, Masahiro Miyashita

Publikováno v: Mass Spectrometry. 6(1)

It has been shown that chemical modification of the peptide N-terminus with a charged tag greatly affects the fragmentation process caused by collision-induced dissociation to obtain more interpretable product ion spectra. In this study, we examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2d220cf4fefa9bcb79fdc1735194e7
http://hdl.handle.net/2433/282108

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Efficacy of Single Intravenous Injection of Peramivir against Influenza B Virus Infection in Ferrets and Cynomolgus Macaques

Autor: Hideaki Ishida, Misako Nakayama, Akihiko Sato, Hirohito Ishigaki, Kazumasa Ogasawara, Yasushi Itoh, Takushi Kanazu, Kaoru Baba, Takahiro Noda, Kenji Sato, Ryu Yoshida, Makoto Kodama, Ryuzo Torii, Mitsutaka Kitano, Yoichiro Nihashi

Publikováno v: Antimicrobial Agents and Chemotherapy. 55:4961-4970

We evaluated the efficacy of a single intravenous dose peramivir for treatment of influenza B virus infection in ferrets and cynomolgus macaques in the present study. A single dose of peramivir (60 mg/kg of body weight) given to ferrets on 1 day post

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872e27ecc0ac4c258124ad9f0e39e81f
https://doi.org/10.1128/aac.00412-11

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Differential (14)N/(15)N-Labeling of Peptides Using N-Terminal Charge Derivatization with a High-Proton Affinity for Straightforward de novo Peptide Sequencing

Autor: Masahiro Miyashita, Hiroyuki Awane, Yoichiro Nihashi, Hisashi Miyagawa

Publikováno v: Mass spectrometry (Tokyo, Japan). 2(1)

While de novo peptide sequencing is essential in many situations, it remains a difficult task. This is because peptide fragmentation results in complicated and often incomplete product ion spectra. In a previous study, we demonstrated that N-terminal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28c8420c004350382d7204268e887eb
https://pubmed.ncbi.nlm.nih.gov/24860714

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Phytotoxic sesterterpene, 11-epiterpestacin, from Bipolaris sorokiniana NSDR-011

Autor: Chi-Hwan Lim, Yoichiro Nihashi, Tamio Ueno, Hisashi Miyagawa, Chihiro Tanaka

Publikováno v: Bioscience, biotechnology, and biochemistry. 66(3)

The structure of siccanol, a phytotoxic sesterterpene of fungal origin, was analyzed after chemical conversion by NMR spectroscopy. Siccanol was found to be an epimer of terpestacin that has been isolated from Arthrinium sp., and was thus renamed 11-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e1f08757a8e81d60aeeb66f5656859
https://pubmed.ncbi.nlm.nih.gov/12005073

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