Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Yoichiro Kusakari"'
Autor:
Kazuhiro Kuga, Yoichiro Kusakari, Ken Uesugi, Kentaro Semba, Takashi Urashima, Toru Akaike, Susumu Minamisawa
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231905 (2020)
Myocardial fibrosis is often associated with cardiac hypertrophy; indeed, fibrosis is one of the most critical factors affecting prognosis. We aimed to identify the molecules involved in promoting fibrosis under hypertrophic stimuli. We previously es
Externí odkaz:
https://doaj.org/article/e064458f725645a9aba63650a369a1ce
Autor:
Yoichiro Kusakari, Takashi Urashima, Daisuke Shimura, Erika Amemiya, Genki Miyasaka, Shunsuke Yokota, Yoshitaka Fujimoto, Toru Akaike, Takahiro Inoue, Susumu Minamisawa
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169564 (2017)
Interstitial myocardial fibrosis is one of the factors responsible for dysfunction of the heart. However, how interstitial fibrosis affects cardiac function and excitation-contraction coupling (E-C coupling) has not yet been clarified. We developed a
Externí odkaz:
https://doaj.org/article/0af6335c3e7a42c69bb60fc8f4108a91
Autor:
Yoshitaka Fujimoto, Takashi Urashima, Daisuke Shimura, Reiji Ito, Sadataka Kawachi, Ichige Kajimura, Toru Akaike, Yoichiro Kusakari, Masako Fujiwara, Kiyoshi Ogawa, Nobuhito Goda, Hiroyuki Ida, Susumu Minamisawa
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148666 (2016)
BACKGROUND:Hepatic fibrosis progresses with right heart failure, and becomes cardiac cirrhosis in a severe case. Although its causal factor still remains unclear. Here we evaluated the progression of hepatic fibrosis using a pulmonary artery banding
Externí odkaz:
https://doaj.org/article/91d85b372bbc4a8eb84c7587a2ca18c9
Autor:
Peng Zhang, Kara Ford, Jae Hwi Sung, Jacob Moeller, Yuta Suzuki, Iuliia Polina, Toshiaki Tachibana, Yoichiro Kusakari, Michael W Cypress, Isabel Chaput, Kamelia Drenkova, Maria Landherr, Stephanie M Adaniya, Jyotsna Mishra, Ulrike Mende, Bong Sook Jhun, Jin O-Uchi
Contact sites between the mitochondria and endoplasmic reticulum (ER) are irregulates the exchange of lipids, Ca2+, and reactive oxygen species (ROS) across the two organelles. Mitofusin 2 (Mfn2) has been shown as one of the major components tetherin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdb191a94eb95d2a80587c83113fd4e7
https://doi.org/10.1101/2022.02.21.481295
https://doi.org/10.1101/2022.02.21.481295
Autor:
Jessica L. Cao, Jin O-Uchi, Yuta Suzuki, Stephanie M. Adaniya, Bong Sook Jhun, Yoichiro Kusakari, Michael W. Cypress
Publikováno v:
Archives of Biochemistry and Biophysics. 663:276-287
Recent discoveries of the molecular identity of mitochondrial Ca(2+) influx/efflux mechanisms have placed mitochondrial Ca(2+) transport at center stage in views of cellular regulation in various cell-types/tissues. Indeed, mitochondria in cardiac mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656b903e3addb774436082f0b91bdc85
https://doi.org/10.1016/j.abb.2019.01.027
https://doi.org/10.1016/j.abb.2019.01.027
Autor:
Toru Akaike, Susumu Minamisawa, Yoichiro Kusakari, Ken Uesugi, Kazuhiro Kuga, Takashi Urashima, Kentaro Semba
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231905 (2020)
PLoS ONE
PLoS ONE
Myocardial fibrosis is often associated with cardiac hypertrophy; indeed, fibrosis is one of the most critical factors affecting prognosis. We aimed to identify the molecules involved in promoting fibrosis under hypertrophic stimuli. We previously es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489b1aec6ad21081e6cdbc71218df52d
https://doaj.org/article/e064458f725645a9aba63650a369a1ce
https://doaj.org/article/e064458f725645a9aba63650a369a1ce
Publikováno v:
Circulation Research. 125
Introduction: The effect of acute ventricular volume overload on organelles such as myofibrils and mitochondria are incompletely understood. Purpose: We performed acute overstretch on cardiac papillary muscle to investigate the functional and morphol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::319ef389f99659bceb314486462be67f
https://doi.org/10.1161/res.125.suppl_1.861
https://doi.org/10.1161/res.125.suppl_1.861
Autor:
Akiko Onda, Yasuhiro Sawada, Qibin Jiao, Yoichiro Kusakari, Susumu Minamisawa, Takayuki Akimoto, Toru Fukubayashi, Hajime Kono, Katsuhiko Suzuki, Toshikazu Miyamoto
Publikováno v:
Muscle & Nerve. 54:788-791
Introduction Disuse-induced skeletal muscle atrophy is a serious concern; however, there is not an effective mouse model to elucidate the molecular mechanisms. We developed a noninvasive atrophy model in mice. Methods After the ankle joints of mice w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b792c58cd8216dade0deeadb8ed722f
https://doi.org/10.1002/mus.25202
https://doi.org/10.1002/mus.25202
Autor:
Qibin Jiao, Gaku Nakai, Atsushi Nakano, Meihua Jin, Yoshihiro Ishikawa, Daisuke Shimura, Tomohiro Yokota, Yoichiro Kusakari, Nobuhito Goda, Tetsuo Sasano, Susumu Minamisawa, Yasuhiro Nakashima
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 310:H92-H103
Sarcolipin (SLN) is a small proteolipid and a regulator of sarco(endo)plasmic reticulum Ca2+-ATPase. In heart tissue, SLN is exclusively expressed in the atrium. Previously, we inserted Cre recombinase into the endogenous SLN locus by homologous reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7d447fcb021e94d98be8a3cdeeec54
https://doi.org/10.1152/ajpheart.00411.2015
https://doi.org/10.1152/ajpheart.00411.2015
Autor:
Gaku Nakai, Ichige Kajimura, Nobuhito Goda, Susumu Minamisawa, Daisuke Shimura, Yoichiro Kusakari, Qibin Jiao, Ken Uesugi, Tomoyoshi Soga
Publikováno v:
Heart and vessels. 34(3)
Fatty acid (FA) oxidation is impaired and glycolysis is promoted in the damaged heart. However, the factor(s) in the early stages of myocardial metabolic impairment remain(s) unclear. C57B6 mice were subcutaneously administered monocrotaline (MCT) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7457d98694cdea25c5670d02cdd7981b
https://pubmed.ncbi.nlm.nih.gov/30386918
https://pubmed.ncbi.nlm.nih.gov/30386918