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pro vyhledávání: '"Yoichi Tamaru"'
Autor:
Ryutaro Nibu, Shoichi Koizumi, Akihiro Yachie, Toshio Miyawaki, Kazuyuki Iwai, Takao Tsuji, Yoichi Tamaru, Noboru Taniguchi
Publikováno v:
Blood. 82:521-527
bcl-2 proto-oncogene encodes an inner mitochondrial membrane protein that blocks programmed cell death (apoptosis). There is now increasing evidence that regulation of bcl-2 expression is a determinant of life or death in normal lymphocytes. We have
Autor:
Harumi Matsukawa, Shoichi Koizumi, Ichiro Ohno, Yoshiki Ueno, Tsuyoshi Ichihara, Yoichi Tamaru
Publikováno v:
Japanese Journal of Cancer Research : Gann
Methotrexate (MTX) is metabolized intracellularly to MTX-polyglutamates (MTX-PGs), which markedly inhibit several folate-dependent enzymes. Polyglutamation defect, therefore, is one of the important factors in drug resistance. In this study, reversal