Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yoichi Takaku"'
Autor:
Tomoto Ura, Nanako Sakakibara, Yu Hirano, Taro Tamada, Yoichi Takakusagi, Kentaro Shiraki, Tsutomu Mikawa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Biological properties of protein molecules depend on their interaction with other molecules, and enzymes are no exception. Enzyme activities are controlled by their interaction with other molecules in living cells. Enzyme activation and thei
Externí odkaz:
https://doaj.org/article/da50f7594286463bb344da6730f57dfb
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/343bc89ac92c48abbc4335685f6cf2ec
Publikováno v:
Japanese Journal of Ophthalmology. 43:166-170
To determine the presence of fluorescein leakage from the iris and angle in normal subjects, and how it is affected by aging.The subjects were 92 normal volunteers and patients with senile cataract who ranged in age from 20 to 93 years and were free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6cf7563266205a5617475ee2bca850
https://doi.org/10.1016/s0021-5155(99)00012-x
https://doi.org/10.1016/s0021-5155(99)00012-x
Autor:
Yoichi Takakusagi, Aya Sugyo, Atsushi B. Tsuji, Hitomi Sudo, Masahiro Yasunaga, Yasuhiro Matsumura, Fumio Sugawara, Kengo Sakaguchi, Tatsuya Higashi
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101285- (2022)
α-Sulfoquinovosylacyl-1,3-propanediol (SQAP) is a semi-synthetic derivative of natural sulfoglycolipid that sensitizes tumors to external-beam radiotherapy. How SQAP affects internal radiotherapy, however, is not known. Here, we investigated the eff
Externí odkaz:
https://doaj.org/article/47bda2ddaee24e27979c80f2bea5f435
Autor:
Yoichi Takakusagi, Ryoma Kobayashi, Keita Saito, Shun Kishimoto, Murali C. Krishna, Ramachandran Murugesan, Ken-ichiro Matsumoto
Publikováno v:
Metabolites, Vol 13, Iss 1, p 69 (2023)
Imaging tumor microenvironments such as hypoxia, oxygenation, redox status, and/or glycolytic metabolism in tissues/cells is useful for diagnostic and prognostic purposes. New imaging modalities are under development for imaging various aspects of tu
Externí odkaz:
https://doaj.org/article/735f4e39628245c1ac029f12a7320d2a
Autor:
Hiroshi Nonaka, Yuki Nakanishi, Satoshi Kuno, Tomoki Ota, Kentaro Mochidome, Yutaro Saito, Fuminori Sugihara, Yoichi Takakusagi, Ichio Aoki, Satoru Nagatoishi, Kouhei Tsumoto, Shinsuke Sando
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The enzyme serine hydroxymethyltransferase (SHMT) has been implicated in several diseases, however is hard to investigate. Here, the authors used a design strategy based on the retro-aldol-type reaction catalyzed by SHMT to develop SHMT-responsive fl
Externí odkaz:
https://doaj.org/article/95960802fdea4dd5b7793046d2f3732b
Publikováno v:
Experimental Eye Research. 24:1-6
Acid lipase in the retinal pigment epithelium of the bovine eye was studied biochemically using triglyceride as substrate. The retinal pigment epithelium revealed the highest specific activity, the activity being highest in the lysosomal fraction. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4600c34ed12110665e817fc50c0b1002
https://doi.org/10.1016/0014-4835(77)90278-0
https://doi.org/10.1016/0014-4835(77)90278-0
Publikováno v:
Experimental Eye Research. 26:57-63
Cathepsin B in the bovine eye was studied biochemically using α- N -benzoyl- l -arginine amide as substrate. The highest specific activity of cathepsin B was observed in the ciliary body among bovine eye tissues, the activity being highest in the ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1149d712f5a5d8532a98ddda537fc827
https://doi.org/10.1016/0014-4835(78)90151-3
https://doi.org/10.1016/0014-4835(78)90151-3
Autor:
Fumio Sugawara, Susumu Kobayashi, Kengo Sakaguchi, Kengo Morohashi, Keisuke Ohta, Satoko Aoki, Senko Tsukuda, Kouji Kuramochi, Yoichi Takakusagi, Mihoko Takami
Publikováno v:
Molecules, Vol 16, Iss 5, Pp 4278-4294 (2011)
Etoposide (VP-16) is an anti-tumor compound that targets topoisomerase II (top II). In this study, we have identified an alternative binding protein of etoposide by screening a library of T7 phage-displayed peptides. After four rounds of selection us
Externí odkaz:
https://doaj.org/article/7fbbc1c93526420daeaa1e983505e713
Autor:
Yoichi Takakusagi, Shingo Matsumoto, Keita Saito, Masayuki Matsuo, Shun Kishimoto, Jonathan W Wojtkowiak, William DeGraff, Aparna H Kesarwala, Rajani Choudhuri, Nallathamby Devasahayam, Sankaran Subramanian, Jeeva P Munasinghe, Robert J Gillies, James B Mitchell, Charles P Hart, Murali C Krishna
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107995 (2014)
TH-302 is a hypoxia-activated prodrug (HAP) of bromo isophosphoramide mustard that is selectively activated within hypoxic regions in solid tumors. Our recent study showed that intravenously administered bolus pyruvate can transiently induce hypoxia
Externí odkaz:
https://doaj.org/article/0938aa4f3d55486b8f95bb9b28022c2c