Výsledky vyhledávání - "Yoichi Ohshima"

Akademický článek

Mutations in the β-amyloid precursor protein in familial Alzheimer’s disease increase Aβ oligomer production in cellular models

Autor: Yoichi Ohshima, Katsutoshi Taguchi, Ikuko Mizuta, Masaki Tanaka, Takami Tomiyama, Fuyuki Kametani, Chihiro Yabe-Nishimura, Toshiki Mizuno, Takahiko Tokuda

Publikováno v: Heliyon, Vol 4, Iss 1 (2018)

Soluble oligomers of amyloid-β (Aβ) peptides (AβOs) contribute to neurotoxicity in Alzheimer’s disease (AD). However, it currently remains unknown whether an increase in AβOs is the common phenotype in cellular and animal models. Furthermore, i

Externí odkaz: https://doaj.org/article/488c17ac603945d0acd4349798871601

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Akademický článek

Clioquinol Increases the Expression of VGF, a Neuropeptide Precursor, Through Induction of c-Fos Expression

Autor: Masato Katsuyama, Masakazu Ibi, Misaki Matsumoto, Kazumi Iwata, Yoichi Ohshima, Chihiro Yabe-Nishimura

Publikováno v: Journal of Pharmacological Sciences, Vol 124, Iss 4, Pp 427-432 (2014)

Clioquinol was used extensively in the mid-1900s as an amebicide to treat indigestion and diarrhea. It was eventually withdrawn from the market because it was linked to subacute myelo-optic neuropathy (SMON) in Japan. However, the pathogenesis of SMO

Externí odkaz: https://doaj.org/article/9cf493a5eda244fe9894263f5b8a6df2

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Akademický článek

Nicotine and methyl vinyl ketone, major components of cigarette smoke extracts, increase protective amyloid-β peptides in cells harboring amyloid-β precursor protein.

Autor: Yoichi Ohshima^1,2, Kazumi Iwata¹, Masakazu Ibi¹, Misaki Matsumoto¹, Masato Katsuyama³, Chihiro Yabe-Nishimura¹ nchihiro@koto.kpu-m.ac.jp

Publikováno v: Journal of Toxicological Sciences. Aug2018, Vol. 43 Issue 4, p257-266. 10p.

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Nicotine and methyl vinyl ketone, major components of cigarette smoke extracts, increase protective amyloid-β peptides in cells harboring amyloid-β precursor protein

Autor: Misaki Matsumoto, Yoichi Ohshima, Masakazu Ibi, Masato Katsuyama, Kazumi Iwata, Chihiro Yabe-Nishimura

Publikováno v: The Journal of toxicological sciences. 43(4)

The increased ratio of longer amyloid-β (Aβ1-42)/shorter amyloid-β (Aβ1-40) peptides, generated from amyloid precursor protein (APP), is known to promote the development of Alzheimer's disease (AD). To investigate the role of smoking in Aβ produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe46257c6b061f4214b7db0d6998074
https://pubmed.ncbi.nlm.nih.gov/29618714

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Mutations in the β-amyloid precursor protein in familial Alzheimer’s disease increase Aβ oligomer production in cellular models

Autor: Takahiko Tokuda, Toshiki Mizuno, Ikuko Mizuta, Yoichi Ohshima, Masaki Tanaka, Chihiro Yabe-Nishimura, Katsutoshi Taguchi, Takami Tomiyama, Fuyuki Kametani

Publikováno v: Heliyon
Heliyon, Vol 4, Iss 1 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8b2570dbbed5d7c2c5ef46d790ef89
http://europepmc.org/articles/PMC5857613

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Clioquinol Increases the Expression of VGF, a Neuropeptide Precursor, Through Induction of c-Fos Expression

Autor: Kazumi Iwata, Chihiro Yabe-Nishimura, Misaki Matsumoto, Masakazu Ibi, Yoichi Ohshima, Masato Katsuyama

Publikováno v: Journal of Pharmacological Sciences, Vol 124, Iss 4, Pp 427-432 (2014)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049baae670f5368cb85d6f761c0e943d
http://www.sciencedirect.com/science/article/pii/S1347861319301653

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Intracranial deep white matter lesions (DWLs) are associated with chronic kidney disease (CKD) and cognitive impairment: A 5-year follow-up magnetic resonance imaging (MRI) study

Autor: Yoichi Ohshima, Kei Yamada, Kazuo Takeda, Sanae Matsumoto, Yoshiyuki Watanabe, Masanori Nakagawa, Toshiki Mizuno, Masaki Kondo, Etsuko Ozaki, Satoko Mitani, Nagato Kuriyama, Masako Shigeta

Publikováno v: Archives of Gerontology and Geriatrics. 56:55-60

A B S T R A C T Stroke incidence and cognitive decline are related to progression of arteriosclerosis in intracranial DWLs. However, the relationships between DWLs and factors associated with their progression, including CKD, have not been fully eluc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5322c461037be2bbbf56e5bf259291
https://doi.org/10.1016/j.archger.2011.11.009

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NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early stage diabetic kidney

Autor: Misaki Matsumoto, Kazumi Iwata, Jia Zhang, Masakazu Ibi, Chihiro Yabe-Nishimura, Kai Zhu, Masato Katsuyama, Ashraf Taye, Kumar Sharma, Junjie Liu, Yoichi Ohshima, Xiaopeng Wen, Tomoko Kakehi, ChunYuan Fan

Publikováno v: Free radical biologymedicine. 83

Increased oxidative stress and activation of protein kinase C (PKC) under hyperglycemia have been implicated in the development of diabetic nephropathy. Because reactive oxygen species derived from nicotinamide adenine dinucleotide phosphate (NADPH)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e4b747ed1743b00290ef854bbc1762
https://pubmed.ncbi.nlm.nih.gov/25701431

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Low vitamin and carotenoid levels are related to cerebral white matter lesions

Autor: Nagato Kuriyama, Kotaro Ozasa, Toshiki Mizuno, Yoichi Ohshima, Tsunehiko Nishimura, Kei Yamada, Soichi Matsumoto, Kazuo Takeda, Yoshiyuki Watanabe, Yoshinari Nagakane, Masanori Nakagawa, T Miyazaki, Masaki Kondo

Publikováno v: The journal of nutrition, healthaging. 17(5)

To determine the effects of vitamins and carotenoids on brain white matter lesions (WMLs), we examined the associations between WMLs with vitamin and carotenoid levels in Japanese middle-aged and elderly subjects.Four-hundred and sixty-nine healthy p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bcc092d24bf56b8cdc5ecea42a36f6
https://pubmed.ncbi.nlm.nih.gov/23636547

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Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension

Autor: Hiroshi Itoh, Kenichiro Kinouchi, Akira Nishiyama, Kanako Murohashi-Bokuda, Tatsuya Narita, Masaki Ryuzaki, Mariyo Sakoda, Yoichi Ohshima, Asako Kurauchi-Mito, Atsuhiro Ichihara

Publikováno v: Hypertension research : official journal of the Japanese Society of Hypertension. 34(3)

The handle region peptide (HRP), a (pro)renin receptor (P)RR blocker, did not prevent the acute nephropathy occurring 2 weeks after clipping in renovascular hypertensive rats. This study was performed to examine the effects of HRP, its scramble pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af456904cfd971d9067c6925eb5c728a
https://pubmed.ncbi.nlm.nih.gov/21179099

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