Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Yoichi Imai"'
Autor:
Emi Sugimoto, Jingmei Li, Yasutaka Hayashi, Kohei Iida, Shuhei Asada, Tsuyoshi Fukushima, Moe Tamura, Shiori Shikata, Wenyu Zhang, Keita Yamamoto, Kimihito Cojin Kawabata, Tatsuya Kawase, Takeshi Saito, Taku Yoshida, Satoshi Yamazaki, Yuta Kaito, Yoichi Imai, Tamami Denda, Yasunori Ota, Tomofusa Fukuyama, Yosuke Tanaka, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Immunotherapy has attracted considerable attention as a therapeutic strategy for cancers including acute myeloid leukemia (AML). In this study, we found that the development of several aggressive subtypes of AML is slower in Rag2 −/− mic
Externí odkaz:
https://doaj.org/article/5b6b8d5e72fb4e78b3b3547dd6332877
Autor:
Yuta Kaito, Emi Sugimoto, Fumi Nakamura, Yutaka Tsukune, Makoto Sasaki, Shunsuke Yui, Hiroki Yamaguchi, Susumu Goyama, Yasuhito Nannya, Kinuko Mitani, Hideto Tamura, Yoichi Imai
Publikováno v:
Haematologica, Vol 109, Iss 4 (2023)
Acute myeloid leukemia (AML) is a hematologic malignancy that frequently relapses, even if remission can be achieved with intensive chemotherapy. One known relapse mechanism is the escape of leukemic cells from immune surveillance. Currently, there i
Externí odkaz:
https://doaj.org/article/3560553c000846369e1641d594303952
Publikováno v:
Life, Vol 13, Iss 8, p 1701 (2023)
Positron emission tomography (PET) is an imaging modality used for the noninvasive assessment of tumor staging and response to therapy. PET with 18F labeled fluorodeoxyglucose (18F-FDG PET) is widely used to assess the active and inactive lesions in
Externí odkaz:
https://doaj.org/article/634f1af07f1540769cc22c27398bb000
Autor:
Hirohito Kubota, Tatsuya Masuda, Mina Noura, Kana Furuichi, Hidemasa Matsuo, Masahiro Hirata, Tatsuki R. Kataoka, Hidefumi Hiramatsu, Takahiro Yasumi, Tatsutoshi Nakahata, Yoichi Imai, Junko Takita, Souichi Adachi, Hiroshi Sugiyama, Yasuhiko Kamikubo
Publikováno v:
eJHaem, Vol 2, Iss 3, Pp 449-458 (2021)
Abstract Patients with refractory graft‐versus‐host disease (GVHD) have a dismal prognosis. Therefore, novel therapeutic targets are still needed to be identified. Runt‐related transcriptional factor (RUNX) family transcription factors are esse
Externí odkaz:
https://doaj.org/article/39a81355ca654041a0dc03073ab37733
Autor:
Mitsuhito Hirano, Yoichi Imai, Yuta Kaito, Takahiko Murayama, Kota Sato, Tadao Ishida, Junichi Yamamoto, Takumi Ito, Muneyoshi Futami, Masaki Ri, Hiroshi Yasui, Tamami Denda, Yukihisa Tanaka, Yasunori Ota, Masanori Nojima, Yasuhiko Kamikubo, Noriko Gotoh, Shinsuke Iida, Hiroshi Handa, Arinobu Tojo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)
Abstract Background Multiple myeloma (MM) is an incurable disease. The acquisition of resistance to drugs, including immunomodulatory drugs (IMiDs), has a negative effect on its prognosis. Cereblon (CRBN) is a key mediator of the bioactivities of IMi
Externí odkaz:
https://doaj.org/article/f2e71599d7d641fb9ece99c28c22cc0d
Autor:
Yohei Iimura, Tomohiro Kurokawa, Shohei Andoh, Yoshiaki Kanemoto, Toyotaka Kawamata, Kentaro Yazawa, Aki Sato, Kazuaki Yokoyama, Yoichi Imai, Giichiro Tsurita, Yuka Ahiko, Susumu Aikou, Dai Shida, Masanori Nojima, Arinobu Tojo, Munetoshi Sugiura, Seiichiro Kuroda
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss , Pp 111929- (2021)
Background: Clinical evidence of thiamine-related neuropsychiatric symptoms, including the initial stage, is limited because serum thiamine levels tend to be evaluated only for patients who develop severe neuropsychiatric symptoms suspected to be rel
Externí odkaz:
https://doaj.org/article/3503f43786e5472da18f5038debddd3e
Autor:
Muneyoshi Futami, Keisuke Suzuki, Satomi Kato, Saori Ohmae, Yoshio Tahara, Masanori Nojima, Yoichi Imai, Takayuki Mimura, Yoshihiro Watanabe, Arinobu Tojo
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231896 (2020)
Cancer immunotherapy using chimeric antigen receptor-armed T (CAR T) cells have been shown to improve outcomes significantly in patients with hematological malignancies. However, cytokine release syndrome (CRS) remains a risk. CRS is characterized by
Externí odkaz:
https://doaj.org/article/cd02f8fc793149a99c6411bd33e19ae9
Autor:
Yoichi Imai
Publikováno v:
Cancers, Vol 12, Iss 9, p 2544 (2020)
Specialists in the field of multiple myeloma (MM) research have written a series of 12 articles (2 original articles, 10 reviews) in the Special Issue “Latest Development in Multiple Myeloma” [...]
Externí odkaz:
https://doaj.org/article/d982efb3b7ad4755a45cde466550ffca
Publikováno v:
Cancers, Vol 11, Iss 4, p 475 (2019)
HDACs are critical regulators of gene expression that function through histone modification. Non-histone proteins and histones are targeted by these proteins and the inhibition of HDACs results in various biological effects. Moreover, the aberrant ex
Externí odkaz:
https://doaj.org/article/9609f44095464599909e7849eecae182
Autor:
Shintaro Imamura, Junzo Uchiyama, Eriko Koshimizu, Jun-Ichi Hanai, Christina Raftopoulou, Ryan D Murphey, Peter E Bayliss, Yoichi Imai, Caroline Erter Burns, Kenkichi Masutomi, Sarantis Gagos, Leonard I Zon, Thomas M Roberts, Shuji Kishi
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3364 (2008)
Although it is clear that telomerase expression is crucial for the maintenance of telomere homeostasis, there is increasing evidence that the TERT protein can have physiological roles that are independent of this central function. To further examine
Externí odkaz:
https://doaj.org/article/598a1d2975284ac7a54c4410cf45e9ec