Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Yoichi Ezura"'
Autor:
Daniela Tiaki Uehara, Tomoki Muramatsu, Senichi Ishii, Hidetsugu Suzuki, Kazuyuki Fukushima, Yasuhiro Arasaki, Tadayoshi Hayata, Johji Inazawa, Yoichi Ezura
Publikováno v:
JBMR Plus, Vol 7, Iss 9, Pp n/a-n/a (2023)
ABSTRACT Gorham–Stout disease (GSD), also called vanishing bone disease, is a rare osteolytic disease, frequently associated with lymphangiomatous tissue proliferation. The causative genetic background has not been noted except for a case with a so
Externí odkaz:
https://doaj.org/article/9e734213f4424fd696591ff7e90ae61b
Autor:
Zhu Ling, Hailati Aini, Shuhei Kajikawa, Jumpei Shirakawa, Kunikazu Tsuji, Yoshinori Asou, Hideyuki Koga, Ichiro Sekiya, Akira Nifuji, Masaki Noda, Yoichi Ezura
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1395 (2023)
A novel osteolytic disorder due to PFN1 mutation was discovered recently as early-onset Paget’s disease of bone (PDB). Bone loss and pain in adult PDB patients have been treated using bisphosphonates. However, therapeutic strategies for this specif
Externí odkaz:
https://doaj.org/article/63d96df7c0934834be996e83a07c3837
Autor:
Jumpei Shirakawa, Shuhei Kajikawa, Ralph T Böttcher, Mercedes Costell, Yayoi Izu, Tadayoshi Hayata, Masaki Noda, Yoichi Ezura
Publikováno v:
JBMR Plus, Vol 3, Iss 6, Pp n/a-n/a (2019)
ABSTRACT Profilin 1 (Pfn1), a regulator of actin polymerization, controls cell movement in a context‐dependent manner. Pfn1 supports the locomotion of most adherent cells by assisting actin‐filament elongation, as has been shown in skeletal proge
Externí odkaz:
https://doaj.org/article/3907a79a6c0d454a8173717a14fa1659
Autor:
Takayoshi Kawazoe, Miki Otsuka, Yoshihiro Momota, Chie Kise, Ryuichiro Kobayashi, Yoichi Ezura, Takuya Notomi
Publikováno v:
Journal of Hard Tissue Biology. 30:333-338
Autor:
Takayoshi Kawazoe, Chie Kise, Yoshihiro Momota, Yoichi Ezura, Miki Otsuka, Takuya Notomi, Ryuichiro Kobayashi
Publikováno v:
Journal of Hard Tissue Biology. 30:347-354
Publikováno v:
Journal of Bone and Mineral Metabolism.
Profilin-1 (Pfn1), an evolutionarily conserved actin-binding protein, is an important regulator of the cytoskeleton. We previously reported the osteoclast-specific Pfn1-conditional knockout (cKO) mice had postnatal osteolytic phenotype with craniofac
Autor:
Takuya Oyaizu, Toshio Miyata, Yoshinori Asou, Yoichi Ezura, Aidehamu Aihemaiti, Kunikazu Tsuji, Naoki Yamamoto, Shingo Sato, Jinying Piao, Atsushi Okawa, Hiroki Ochi
Publikováno v:
Biochemical and biophysical research communications. 534
Sarcopenia is among the most common medical problems of the aging population worldwide and a major social concern. Here, we explored the therapeutic potential of TM5484, a novel orally available PAI-1 inhibitor, to prevent sarcopenia. The sarcopenic
Publikováno v:
Biochemical and biophysical research communications. 528(4)
Cytoplasmic polyadenylation element binding (CPEB) proteins are RNA-binding proteins involved in translational regulation of the specific target mRNAs and control function of various organs including brain, liver and hematopoietic system. However, th
Autor:
Ernst Pöschl, Yoshiki Nakamura, Akemi Shimada, Hiroaki Mizukami, Koichiro Komatsu, Bent Brachvogel, Norio Amizuka, Hisashi Ideno, Akira Nifuji, Kazuhisa Nakashima, Yoshinori Arai, Teruhito Yamashita, Yoichi Ezura, Satoshi Wada
Publikováno v:
Journal of Bone and Mineral Research. 33:1532-1543
Little is known about the molecular mechanisms of enthesis formation in mature animals. Here, we report that annexin A5 (Anxa5) plays a critical role in the regulation of bone ridge outgrowth at the entheses. We found that Anxa5 is highly expressed i
Autor:
Shuhei Kajikawa, Sumimasa Arimura, Tadayoshi Hayata, Ryo Ueta, Yoichi Ezura, Yuji Yamanashi, Masaki Noda, Yuu Taguchi, Jun-ichiro Inoue
Publikováno v:
Biochemical and Biophysical Research Communications. 498:967-974
Bone mass is determined by coordinated acts of osteoblasts and osteoclasts, which control bone formation and resorption, respectively. Osteoclasts are multinucleated, macrophage/monocyte lineage cells from bone marrow. The Dok-family adaptors Dok-1,