Zobrazeno 1 - 10 of 130 pro vyhledávání: '"Yoichi, Osawa"'
1
Akademický článek
A General Method to Screen Nanobodies for Cytochrome P450 Enzymes from a Yeast Surface Display Library
Autor: Yudong Sun, Cristian Martinez-Ramos, Eugene Chen, Yoichi Osawa, Haoming Zhang
Publikováno v: Biomedicines, Vol 12, Iss 8, p 1863 (2024)
The availability of yeast surface display nanobody (Nb) libraries offers a convenient way to acquire antigen-specific nanobodies that may be useful for protein structure–function studies and/or therapeutic applications, complementary to the convent
Externí odkaz: https://doaj.org/article/48d1d9bcf2844891870cc53429e0fb8c
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2
Akademický článek
The Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering
Autor: Yudong Sun, Xiaoqiang Huang, Yoichi Osawa, Yuqing Eugene Chen, Haoming Zhang
Publikováno v: Molecules, Vol 28, Iss 14, p 5353 (2023)
Wild-type cytochrome P450 CYP102A1 from Bacillus megaterium is a highly efficient monooxygenase for the oxidation of long-chain fatty acids. The unique features of CYP102A1, such as high catalytic activity, expression yield, regio- and stereoselectiv
Externí odkaz: https://doaj.org/article/f539e846aed847418c23b2b85ba06f46
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3
Akademický článek
Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed CellsSummary
Autor: Dhiman Maitra, Eric L. Carter, Rani Richardson, Laure Rittié, Venkatesha Basrur, Haoming Zhang, Alexey I. Nesvizhskii, Yoichi Osawa, Matthew W. Wolf, Stephen W. Ragsdale, Nicolai Lehnert, Harald Herrmann, M. Bishr Omary
Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 4, Pp 659-682.e1 (2019)
Background & Aims: Porphyrias are caused by porphyrin accumulation resulting from defects in the heme biosynthetic pathway that typically lead to photosensitivity and possible end-stage liver disease with an increased risk of hepatocellular carcinoma
Externí odkaz: https://doaj.org/article/10bdb280b0dd465a91c8c70783932dcc
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9
Dynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase
Autor: Yoshihiro Morishima, Miranda Lau, William B. Pratt, Yoichi Osawa
Publikováno v: The Journal of biological chemistry.
Hsp90 is known to mediate heme insertion and activation of heme-deficient neuronal NO synthase (apo-nNOS) in cells by a highly dynamic interaction that has been extremely difficult to study mechanistically with the use of subcellular systems. In that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15127c1f486259775b12d0150c51c68a
https://pubmed.ncbi.nlm.nih.gov/36596358
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10
Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
Autor: Theodore S. Lawrence, William B. Pratt, Cuyler Dewar, Yoshihiro Morishima, Venkatesha Basrur, Manjunath P. Pai, Koushik Kondapi, Merna Sitto, Mukesh K. Nyati, Sanjima Pal, Dafydd G. Thomas, Theresa Devasia, Ranjit K. Mehta, Matthew J. Schipper, Yoichi Osawa
Publikováno v: Clin Cancer Res
Purpose:Treatment approaches using Hsp90 inhibitors at their maximum tolerated doses (MTDs) have not produced selective tumor toxicity. Inhibition of Hsp90 activity causes degradation of client proteins including those involved in recognizing and rep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39deb73c4a96ec89253bda80832e2cd1
https://doi.org/10.1158/1078-0432.ccr-19-3102
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