Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Yohta Shimada"'
Autor:
Toshiki Tsunogai, Toya Ohashi, Yohta Shimada, Takashi Higuchi, Ayaka Kimura, Ayako M. Watabe, Fusao Kato, Hiroyuki Ida, Hiroshi Kobayashi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 448-460 (2022)
GM1-gangliosidosis is a progressive neurodegenerative glycosphingolipidosis resulting from a GLB1 gene mutation causing a deficiency of the lysosomal enzyme β-galactosidase, which leads to the abnormal accumulation of GM1 ganglioside in the central
Externí odkaz:
https://doaj.org/article/7324db0761c5449a83b52405a909083c
Autor:
Miho Wada, Yohta Shimada, Sayoko Iizuka, Natsumi Ishii, Hiromi Hiraki, Toshiaki Tachibana, Kazuhiro Maeda, Mitsuru Saito, Shoutaro Arakawa, Takuya Ishimoto, Takayoshi Nakano, Hiroyuki Ida, Toya Ohashi, Hiroshi Kobayashi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 261-274 (2020)
Mucopolysaccharidosis type II is a disease caused by organ accumulation of glycosaminoglycans due to iduronate 2-sulfatase deficiency. This study investigated the pathophysiology of the bone complications associated with mucopolysaccharidosis II and
Externí odkaz:
https://doaj.org/article/d2d11fb78c1542e5850cea2f318246be
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Pompe disease (PD) is a lysosomal disorder caused by acid α-glucosidase (GAA) deficiency. Progressive muscular weakness is the major symptom of PD, and enzyme replacement therapy can improve the clinical outcome. However, to achieve a better clinica
Externí odkaz:
https://doaj.org/article/afbdbc9c86034657ad08ae419fbbf912
Autor:
Shuichiro Yamanaka, Shinya Yokote, Akifumi Yamada, Yuichi Katsuoka, Luna Izuhara, Yohta Shimada, Nobuo Omura, Hirotaka James Okano, Takao Ohki, Takashi Yokoo
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157282 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0102311.].
Externí odkaz:
https://doaj.org/article/2875d93810d84ac2bf91918831934712
Autor:
Yohei Sato, Hiroshi Kobayashi, Takashi Higuchi, Yohta Shimada, Takumi Era, Shigemi Kimura, Yoshikatsu Eto, Hiroyuki Ida, Toya Ohashi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
Pompe disease is an autosomal recessive inherited metabolic disease caused by deficiency of acid α-glucosidase (GAA). Glycogen accumulation is seen in the affected organ such as skeletal muscle, heart, and liver. Hypertrophic cardiomyopathy is fre
Externí odkaz:
https://doaj.org/article/999ebf7eadb3414fa9228a6f2ae8b6c7
Autor:
Shuichiro Yamanaka, Shinya Yokote, Akifumi Yamada, Yuichi Katsuoka, Luna Izuhara, Yohta Shimada, Nobuo Omura, Hirotaka James Okano, Takao Ohki, Takashi Yokoo
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102311 (2014)
We previously demonstrated that mesenchymal stem cells (MSCs) differentiate into functional kidney cells capable of urine and erythropoietin production, indicating that they may be used for kidney regeneration. However, the viability of MSCs from dia
Externí odkaz:
https://doaj.org/article/7f3189d737214defb7953367525c6aad
Publikováno v:
Gene Therapy. 30:288-296
A hematopoietic stem cell (HSC) gene therapy (GT) using lentiviral vectors has attracted interest as a promising treatment approach for neuropathic lysosomal storage diseases. To proceed with the clinical development of HSC-GT, evaluation of the ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324e1e81ff74d5e3d8b1aa04d40203db
https://doi.org/10.1038/s41434-022-00357-y
https://doi.org/10.1038/s41434-022-00357-y
Autor:
Yohta Shimada, Mitsuru Yanagaki, Ryoga Hamura, Koichiro Haruki, Kenei Furukawa, Toru Ikegami, Shinji Tanaka, Takashi Horiuchi, Yoshihiro Shirai, Naoki Takada, Tomohiko Taniai, Yasuo Okamoto, Kazuhito Tsuboi, Toya Ohashi, Shu Shimada, Tadashi Uwagawa
Publikováno v:
Cancer Science
Although the inhibition of acid ceramidase (AC) is known to induce antitumor effects in various cancers, there are few reports in pancreatic cancer, and the underlying mechanisms remain unclear. Moreover, there is currently no safe administration met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e207306dc392483093658074aeabfa
http://europepmc.org/articles/PMC8586682
http://europepmc.org/articles/PMC8586682
Autor:
Yumi Kanegae, Tomohiko Taniai, Nobuhiro Saito, Ryoga Hamura, Naoki Takada, Yohta Shimada, Toya Ohashi, Katsuhiko Yanaga, Yoshihiro Shirai, Takashi Horiuchi, Toru Ikegami
Publikováno v:
Cancer Science
Lysosomal degradation plays a crucial role in the metabolism of biological macromolecules supplied by autophagy. The regulation of the autophagy‐lysosome system, which contributes to intracellular homeostasis, chemoresistance, and tumor progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0610479ee28d99b8be10983f2003bdee
https://doi.org/10.1111/cas.14921
https://doi.org/10.1111/cas.14921
Autor:
Toshiki Tsunogai, Toya Ohashi, Yohta Shimada, Takashi Higuchi, Ayaka Kimura, Ayako M. Watabe, Fusao Kato, Hiroyuki Ida, Hiroshi Kobayashi
Publikováno v:
Molecular therapy. Methodsclinical development. 25
GM1-gangliosidosis is a progressive neurodegenerative glycosphingolipidosis resulting from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87bbd6d059746befc655314ac4d0d0f0
https://pubmed.ncbi.nlm.nih.gov/36186953
https://pubmed.ncbi.nlm.nih.gov/36186953