Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Yohsuke Hara"'
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Akademický článek
Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4+ T cell fate
Autor: Fangming Zhu, Ryan J. McMonigle, Andrew R. Schroeder, Xianyou Xia, David Figge, Braxton D. Greer, Edahí González-Avalos, Diego O. Sialer, Yin-Hu Wang, Kelly M. Chandler, Adam J. Getzler, Emily R. Brown, Changchun Xiao, Olaf Kutsch, Yohsuke Harada, Matthew E. Pipkin, Hui Hu
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Follicular helper T (Tfh) cells are essential for germinal center (GC) B cell responses. However, it is not clear which PD-1+CXCR5+Bcl6+CD4+ T cells will differentiate into PD-1hiCXCR5hiBcl6hi GC-Tfh cells and how GC-Tfh cell differentiation
Externí odkaz: https://doaj.org/article/35c086446d634d7882db802bef9f3af3
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3
Akademický článek
Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3
Autor: Roser Tachó-Piñot, Christopher T. Stamper, James I. King, Veronika Matei-Rascu, Erin Richardson, Zhi Li, Luke B. Roberts, John W. Bassett, Felipe Melo-Gonzalez, Rémi Fiancette, I-Hsuan Lin, Alexander Dent, Yohsuke Harada, Conor Finlay, Jenny Mjösberg, David R. Withers, Matthew R. Hepworth
Publikováno v: Cell Reports, Vol 42, Iss 11, Pp 113425- (2023)
Summary: Innate lymphoid cells (ILCs) are tissue-resident effector cells with roles in tissue homeostasis, protective immunity, and inflammatory disease. Group 3 ILCs (ILC3s) are classically defined by the master transcription factor RORγt. However,
Externí odkaz: https://doaj.org/article/035a6f626dd34570abb60d2053c54a08
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6
Akademický článek
Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells
Autor: Daisuke Takahashi, Naomi Hoshina, Yuma Kabumoto, Yuichi Maeda, Akari Suzuki, Hiyori Tanabe, Junya Isobe, Takahiro Yamada, Kisara Muroi, Yuto Yanagisawa, Atsuo Nakamura, Yumiko Fujimura, Aiko Saeki, Mizuki Ueda, Ryohtaroh Matsumoto, Hanako Asaoka, Julie M. Clarke, Yohsuke Harada, Eiji Umemoto, Noriko Komatsu, Takaharu Okada, Hiroshi Takayanagi, Kiyoshi Takeda, Michio Tomura, Koji Hase
Publikováno v: EBioMedicine, Vol 58, Iss , Pp 102913- (2020)
Background: Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disorder with a high prevalence, especially in industrialized countries. Dysbiosis of the intestinal microbiota has been observed in RA patients. For instance, new-onset untre
Externí odkaz: https://doaj.org/article/1f63ab6004a146fa8e8dd2e2492aca39
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7
Akademický článek
High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients.
Autor: Yuka Nozaki, Hitomi Motomura, Shoma Tamori, Yumiko Kimura, Chotaro Onaga, Shotaro Kanai, Yuka Ishihara, Ayaka Ozaki, Yasushi Hara, Yohsuke Harada, Yasunari Mano, Tsugumichi Sato, Keiko Sato, Kazunori Sasaki, Hitoshi Ishiguro, Shigeo Ohno, Kazunori Akimoto
Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0235747 (2020)
Despite development of markers for identification of cancer stem cells, the mechanism underlying the survival and division of cancer stem cells in breast cancer remains unclear. Here we report that PKCλ expression was enriched in basal-like breast c
Externí odkaz: https://doaj.org/article/b04cfed37c1b4f8ab79263c66008449a
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