IL-12 and IL-18 Are Increased and Stimulate IFN-γ Production in Sarcoid Lungs

Autor: Shinichiro Kon, Tachio Tatsuno, Masashi Kurimoto, Haruki Okamura, Noriharu Shijubo, Katsunori Shigehara, M Ohmichi, Ryuji Takahashi, Shosaku Abe, Noriyuki Sato, Yohmei Hiraga

Publikováno v: The Journal of Immunology. 166:642-649

Sarcoidosis is a systemic chronic granulomatous disease of unknown cause. Recent investigations revealed that the cytokine profile in inflamed lesions of sarcoidosis is Th1 dominant. To obtain better immunopathologic understanding of sarcoidosis, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe60deef5a0debced290016d88bb37bf
https://doi.org/10.4049/jimmunol.166.1.642

T helper 1 inhibitor TAK-603 inhibits IFN-gamma and IL-12 production with no effect on IL-18: an observation in sarcoidosis patients

Autor: Ryuji, Takahashi, Noriharu, Shijubo, Katsunori, Shigehara, Yohmei, Hiraga, Shosaku, Abe, Noriyuki, Sato

Publikováno v: Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. 21(3)

Sarcoidosis is immunologically characterized by highly enhanced Th1 responses in active stage. TAK-603 is a new quinoline derivative, which selectively suppresses Th1 cytokine production. Thus, the present study was designed to investigate whether TA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d446c6ca3ea8e2c306f92623c99c267b
https://pubmed.ncbi.nlm.nih.gov/15554077

[A comparative study of cefepime for bacterial pneumonia]

Autor: Atsushi SAITO, Yoshiteru SHIGENO, Yuei IRABU, Hiroshi FUKUHARA, Soukichi ONODERA, Hitoshi NAKANO, Tetsuo SHIMIZU, Nobuhiro SASAKI, Hirotaka HASHIZUME, Yuka FUJITA, Takashi HIROSHIMA, Eiichi SAKAI, Akira SAITO, Ichiro NAKAYAMA, Yohmei HIRAGA, Mitsuhide OHMICHI, Kazuo TAKEBA, Ken OSONOI, Miyoko SAITO, Hirohisa KURODA, Masao TAMURA, Kazuki KONISHI, Yoshiaki MORI, Akiho OBARA, Kazuo OBARA, Hitoshi KOBAYASHI, Junichi OGAWA, Kunio KUDO, Munehiko ISHII, Masakichi MOTOMIYA, Akira WATANABE, Yoshihiro HONDA, Yutaka TOKUE, Mitsunobu HONMA, Masataka KATSU, Keisuke KUGA, Junzaburou KABE, Hitoshi ARIOKA, Hiroko ARIOKA, Masaru KOYAMA, Kouichiro NAKATA, Yoshitaka NAKAMORI, Osamu SAKAI, Jingorou SHIMADA, Kohya SHIBA, Masaki YOSHIDA, Hiroichi TANIMOTO, Tetsuo OKAMURA, Hiroyuki KOBAYASHI, Toru SAKAYORI, Hiroshi OSHITANI, Hiroaki TAKEDA, Shoichiro IRIMAJIRI, Yasuo MATSUOKA, Mitsuo OBANA, Takao OKUBO, Hirotada IKEDA, Fumio MATSUMOTO, Iwao SAKURAI, Takayuki TAKAHASHI, Shigeki ODAGIRI, Hiroshi TAKAHASHI, Kenichi TAKAHASHI, Yasutsugu AMANO, Takashi SAKUMA, Masaaki ARAKAWA, Koichi WADA, Takashi KAWASHIMA, Masanaga TAKATO, Shigeyuki HOSHINO, Osamu SEKINE, Yasutoshi SUZUKI, Toshihiko TAKEUCHI, Yoshimitsu HAYASHI, Kazuhide YAMAMOTO, Toshihiko YAMAMOTO, Kanzo SUZUKI, Toru MATSUURA, Satoru ADACHI, Fumiyuki KUZE, Takako MURAYAMA, Nobuo INABA, Yoshio ODA, Akira KAGIOKA, Fumio MIKI, Rinzo SOEJIMA, Yoshihito NIKI, Jiro HINO, Masaru SUMI, Toshiharu MATSUSHIMA, Masayoshi KAWANISHI, Makoto KIMURA, Shunkichi HIRAKI, Yohichi WATANABE, Masashi ARAKI, Takao SASAKI, Yukio MATSUMOTO, Yuji SUGIMOTO, Hidemi TERAMOTO, Michiro YAMAKIDO, Kenji HASEGAWA, Takashi TSUYA, Kenichiro SADAMOTO, Masao KUWABARA, Masanobu OKADA, Kenichi ARITA, Masao DOI, Kazuhiro DAIDO, Jitsuro YANAGIDA, Kenichiro WATANABE, Yuichi ATA, Motohiro SUGIHARA, Masato YUKUTAKE, Kouichi AWAYA, Yoshihisa IHARA, Yoshihiro SAWAE, Nobuyuki SHIMONO, Yukio KUMAGAI, Takahito HIROSE, Kei SATO, Kohtaro OHIZUMI, Youichiro ICHIKAWA, Masako TANAKA, Yoshiyuki MITSUTAKE, Kazuma FUJINO, Mikio KUBUSHIRO, Toshihiro HIGASHI, Kohei HARA, Shigeru KOHNO, Hironobu KOGA, Mitsuo KAKU, Keizo MATSUMOTO, Kazunori OHISHI, Kiyoshi SHIMA, Shinobu TAKENAKA, Masaru NASU, Yoichiro GOTO, Tohru YAMAZAKI, Hiroyuki NAGAI, Takayoshi TASHIRO, Hiroshi NAGAOKA, Kaoru NAKAMA, Nobuya OGAWA, Nobuchika KUSANO

Publikováno v: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 66(7)

The efficacy, safety and usefulness of cefepime (CFPM), a new cephem antibiotic, in bacterial pneumonia, were evaluated in a comparative study against ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0 g (nomi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184e40e9efdf2d2d172feaf4e0c0f613
https://pubmed.ncbi.nlm.nih.gov/1431364

[A comparative study of cefepime for chronic respiratory tract infections]

Autor: Atsushi SAITO, Yoshiteru SHIGENO, Yuei IRABU, Hiroshi FUKUHARA, Hajime OHSHIRO, Takahiko MIYAKUNI, Jun INATOME, Soukichi ONODERA, Hitoshi NAKANO, Tetsuo SHIMIZU, Nobuhiro SASAKI, Toshiaki FUJIKANE, Yuka FUJITA, Takashi HIROSHIMA, Eiichi SAKAI, Akira SAITO, Yohmei HIRAGA, Mitsuhide OHMICHI, Tsukasa YOSHIDA, Hiromi KANAYAMA, Toshiharu ITO, Tamotsu TAKISHIMA, Yasuo TANNO, Ruriko SATO, Makoto TAKAHASHI, Masaharu SUGIYAMA, Masakichi MOTOMIYA, Akira WATANABE, Yoshihiro HONDA, Yutaka TOKUE, Kazunao NIIZUMA, Shigeo TAKIZAWA, Masataka KATSU, Katsutaka TORIKAI, Susumu SUETSUGU, Shunji YOSHIDA, Kaoru SHIMADA, Yasuyuki SANO, Yasuo ARAI, Takeru KOSHINO, Tetsuhei OGAWA, Yoshio KOBAYASHI, Hiroyuki KOBAYASHI, Takao OKUBO, Hirotada IKEDA, Shigeki ODAGIRI, Masanori MATSUMURA, Yasuhiko ASHIKARI, Yasutsugu AMANO, Akira SHOJI, Takashi SAKUMA, Nobuki AOKI, Kenzo TAKAGI, Kenichi YAMAKI, Kiyoshi SUZUKI, Yasunobu NODA, Hideo GONDA, Toshihiko TAKEUCHI, Johichi KATO, Fumiyuki KUZE, Takako MURAYAMA, Nobuaki IKEDA, Koichi NAKATANI, Kenji BANDO, Souichiro IKEDA, Tadaaki KURODA, Nobuhiro NARITA, Masayoshi SAWAKI, Keiichi MIKASA, Fumio MIKI, Rinzo SOEJIMA, Yoshihito NIKI, Jiro HINO, Masaru SUMI, Toshiharu MATSUSHIMA, Masayoshi KAWANISHI, Makoto KIMURA, Shunkichi HIRAKI, Yohichi WATANABE, Masashi ARAKI, Michiro YAMAKIDO, Kenji HASEGAWA, Takashi TSUYA, Kenichiro SADAMOTO, Masao KUWABARA, Masanobu OKADA, Kenichi ARITA, Masao DOI, Kazuhiro DAIDO, Jitsuro YANAGIDA, Kenichiro WATANABE, Yuichi ATA, Motohiro SUGIHARA, Masato YUKUTAKE, Kouichi AWAYA, Yoshihisa IHARA, Minoru YOSHIDA, Kentaro WATANABE, Takahito HIROSE, Kei SATO, Kohtaro OHIZUMI, Youichiro ICHIKAWA, Masako TANAKA, Kazuma FUJINO, Yoshiyuki MITSUTAKE, Mikio KUBUSHIRO, Toshihiro HIGASHI, Susumu HARADA, Yasuko HARADA, Kohei HARA, Shigeru KOHNO, Hironobu KOGA, Mitsuo KAKU, Keizo MATSUMOTO, Kazunori OHISHI, Hiroshi TANAKA, Kiyoshi SHIMA, Shinobu TAKENAKA, Masaru NASU, Yoichiro GOTO, Tohru YAMAZAKI, Hiroyuki NAGAI, Takayoshi TASHIRO, Nobuya OGAWA, Nobuchika KUSANO

Publikováno v: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 66(7)

The clinical efficacy, safety and usefulness of Cefepime (CFPM), a new cephem antibiotics, in chronic respiratory infections were evaluated in a comparative study against Ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8564d4187ea983ae8272e55dbfeb61
https://pubmed.ncbi.nlm.nih.gov/1431365

Clinical Studies on KW-1062

Autor: Minoru Yokoyama, Otohiko Kunii, Shiro Miwa, Yohmei Hiraga, Keimei Mashimo, Seiki Okamura, Hiroyuki Kobayashi, Nobuo Maekawa, Mitsuo Obana, Hideo Sasaki, Takahashi Isao, Osamu Kurimura, Haruhiko Tokuomi, Keiichi Nakagawa, Yoshiji Yamane, Osamu Kitamoto, Mitsuhiko Kuroda, Ryohyuh Takeda, Akio Aoyagi, Kohki Hoshikawa, Kazue Tamaki, Norio Kikuchi, Kohji Kikuchi, Izumi Hayashi, Michiyasu Nakanishi, Yasuko Haneda, Kaoru Ohyama, Osamu Sekine, Tadashi Takigami, Ippei Fujimori, Kazuo Takebe, Kazufuto Fukaya, Ken-ichi Imamura, Shohhei Watanabe, Yasutsugu Fukuda, Sumio Yamaoka, Mamoru Yumita, Kenji Mitsui, Katsumasa Tokunaga

Publikováno v: Journal of the Japanese Association for Infectious Diseases. 54:139-156

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccdc5774ddd19be0ccf1db2014309ee7
https://doi.org/10.11150/kansenshogakuzasshi1970.54.139