Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yohji A, Minamishima"'
Autor:
Chu-Xia Deng, Hiroshi Katayama, Mutsuko Ouchi, Yohji A. Minamishima, Sam W. Lee, Kaori Sasai, Nobuko Fujiuchi, Toru Ouchi, Subrata Sen, Pat P. Ongusaha
Aurora-A/BTAK/STK15 localizes to the centrosome in the G(2)-M phase, and its kinase activity regulates the G(2) to M transition of the cell cycle. Previous studies have shown that the BRCA1 breast cancer tumor suppressor also localizes to the centros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ae65f1a8f6608ac3d1a089aa7e6e93
https://europepmc.org/articles/PMC5399520/
https://europepmc.org/articles/PMC5399520/
Autor:
Satoshi Miyake, Shun-ichiro Iemura, Shigetsugu Hatakeyama, Noriko Ishida, Hiroyasu Nagahama, Keiichi I. Nakayama, Yohji A. Minamishima, Keiko Nakayama, Tohru Natsume, Masatoshi Kitagawa
Publikováno v:
Developmental Cell. 6:661-672
Although Skp2 has been thought to mediate the degradation of p27 at the G 1 -S transition, Skp2 −/− cells exhibit accumulation of p27 in S-G 2 phase with overreplication. We demonstrate that Skp2 −/− p27 −/− mice do not exhibit the overre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58488201a94b79c7e853b7460c1a6393
https://doi.org/10.1016/s1534-5807(04)00131-5
https://doi.org/10.1016/s1534-5807(04)00131-5
Autor:
Keiko Nakayama, Makoto Nakanishi, Kaoru Tominaga, Kyoji Ikeda, Hiroyuki Takai, Noboru Motoyama, Keiichi I. Nakayama, Hiroyasu Nagahama, Yohji A. Minamishima, Tadasuke Tsukiyama
Publikováno v:
Genes & Development. 14:1439-1447
The recent discovery of checkpoint kinases has suggested the conservation of checkpoint mechanisms between yeast and mammals. In yeast, the protein kinase Chk1 is thought to mediate signaling associated with the DNA damage checkpoint of the cell cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abc4a3582a3d82383b1f0c5820ffd5e1
https://doi.org/10.1101/gad.14.12.1439
https://doi.org/10.1101/gad.14.12.1439
Autor:
Noriko Ishida, Keiko Nakayama, Yohji A. Minamishima, Masaki Matsumoto, Hiroyasu Nagahama, Michiko Shirane, Masatoshi Kitagawa, Keiichi I. Nakayama, Ikuo Nakamichi, Tadasuke Tsukiyama, Shigetsugu Hatakeyama, Ryosuke Tsunematsu, Kyoko Kitagawa
Publikováno v:
Scopus-Elsevier
The ubiquitin-proteasome pathway plays an important role in control of the abundance of cell cycle regulators. Mice lacking Skp2, an F-box protein and substrate recognition component of an Skp1-Cullin-F-box protein (SCF) ubiquitin ligase, were genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9d9a1ef012d33d9b261de6c528c582
https://doi.org/10.1093/emboj/19.9.2069
https://doi.org/10.1093/emboj/19.9.2069
Autor:
Salvador Macip, Stuart A. Aaronson, Yohji A. Minamishima, Takao Ohtsuka, Hoon Ryu, Junji Sagara, Keiichi I. Nakayama, Sam W. Lee
Publikováno v:
Nature cell biology. 6(2)
The apoptosis-associated speck-like protein (ASC) is an unusual adaptor protein that contains the Pyrin/PAAD death domain in addition to the CARD protein-protein interaction domain. Here, we present evidence that ASC can function as an adaptor molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2016a33c6bd28ad718c35b85aa4349
https://pubmed.ncbi.nlm.nih.gov/14730312
https://pubmed.ncbi.nlm.nih.gov/14730312
Publikováno v:
Oncogene. 22(11)
Cyclin G is a transcriptional target gene of tumor suppressor p53. Recent studies present evidence that cyclin G may play a central role in the p53-Mdm2 autoregulated module, but the precise function of cyclin G remains elusive. Here, we show a negat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62097cacce41f00934370081a2c273cd
https://pubmed.ncbi.nlm.nih.gov/12642871
https://pubmed.ncbi.nlm.nih.gov/12642871
Autor:
Michiyo, Saimura, Eishi, Nagai, Kazuhiro, Mizumoto, Naoki, Maehara, Yohji A, Minamishima, Mitsuo, Katano, Kunio, Matsumoto, Toshikazu, Nakamura, Masao, Tanaka
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 8(10)
NK4, composed of the N-terminal hairpin and subsequent four-kringle domains of hepatocyte growth factor (HGF), acts not only as a competitive antagonist of HGF but also as an inhibitor of angiogenesis. By studying the antitumor effect of NK4, we eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4c251d2e92268d2d373f8f54f7ba0a2
https://pubmed.ncbi.nlm.nih.gov/12374695
https://pubmed.ncbi.nlm.nih.gov/12374695
Publikováno v:
Cancer research. 62(4)
The abundance of p27(Kip1), an inhibitor of cell proliferation, is determined by Skp2-dependent proteolysis, the deregulation of which is associated with cancer progression. Lack of Skp2 results in p27(Kip1) accumulation as well as enlargement and po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d5d8b0649e6decf4fa196be0ac26327
https://pubmed.ncbi.nlm.nih.gov/11861371
https://pubmed.ncbi.nlm.nih.gov/11861371
Autor:
Shoko Nishio, Taro Urashima, Eishi Nagai, Michiyo Saimura, Masafumi Nakamura, Yohji A. Minamishima, Masaki Shono, Liwu Qian, Norihiro Sato, Masao Tanaka, Kazuhiro Mizumoto, Naoki Maehara
Publikováno v:
Cancer letters. 170(1)
The tumor microenvironment is one of the key factors affecting the cellular response to radiation; however, the influence of serum concentration on tumor radiosensitivity remains poorly understood. We recently discovered that γ-irradiation of tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7d878c591fe1c43402af225ea1da1d
https://pubmed.ncbi.nlm.nih.gov/11448538
https://pubmed.ncbi.nlm.nih.gov/11448538
Autor:
Masao Tanaka, John L. Farber, Masafumi Nakamura, Kazuhiro Mizumoto, Yohji A. Minamishima, Norihiro Sato, Hikaru Ueno
Publikováno v:
Oncogene. 19(46)
Radiotherapy plays a key role in the treatment of many tumors; however, the precise mechanisms responsible for radiation-induced cell death remain uncertain. We have reported previously that ionizing radiation induces centrosome overduplication in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225407d074a818a0ca2f6df9aeed2b67
https://pubmed.ncbi.nlm.nih.gov/11077445
https://pubmed.ncbi.nlm.nih.gov/11077445