Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yohei Nishizato"'
Autor:
Ryotaro Kubota, Satoru Ikezawa, Hideki Oi, Mari S Oba, Shoki Izumi, Ryoko Tsuno, Leona Adachi, Mako Miwa, Shunji Toya, Yohei Nishizato, Daisuke Haga, Tatsuro Iwane, Kazuyuki Nakagome
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2024)
BackgroundCognitive impairment, a core feature of schizophrenia, is associated with poor outcomes. Pharmacotherapy and psychosocial treatment, when used alone, have inadequate effect sizes for cognitive impairment, leading to recent interest in combi
Externí odkaz:
https://doaj.org/article/d053dcfea4c641fb9d48d0faeba2848a
Autor:
Kazuhito Ikeda, Masao Goda, Shiori Taga, Kantaro Nishigori, Takeshi Enomoto, Yuki Fujii, Ayaka Tatara, Atsushi Kitamura, Mami Kamada, Takashi Hashimoto, Yohei Nishizato
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 371:692-702
In our drug discovery program, we identified a novel orally available and brain-penetrant phosphodiesterase (PDE) 1 inhibitor, 3-methyl-7-(tetrahydro-2H-pyran-4-yl)-2-{[trans-4-(trifluoromethyl)cyclohexyl]-methoxy}imidazo[5,1-f][1,2,4]triazin-4(3H)-o
Autor:
Kazuhito Ikeda, Takeshi Enomoto, Masao Goda, Yohei Nishizato, Mami Kamada, Yuki Fujii, Ayaka Tatara, Atsushi Kitamura, Shiori Taga, Takashi Hashimoto, Kantaro Nishigori
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 93:2
Autor:
Takeshi Kunimatsu, Atsushi Yabunaka, Satoki Imai, Noriko Okahashi, Masashi Yabuki, Yohei Nishizato
Publikováno v:
Toxicology in Vitro. 28:397-402
SMP-028 is a new compound for treatment of asthma. Oral administration of SMP-028 to rats was associated with toxicological events in endocrine organs. These events mainly consisted of pathological changes in the adrenal gland, testis, prostate, semi
Autor:
Yoko Urasaki, Shin Irie, Hiroshi Takane, Yohei Nishizato, Shun Higuchi, Ichiro Ieiri, Kenji Otsubo, Takeshi Hirota, Akinori Urae, Hiroyuki Kusuhara, Hiroshi Suzuki, Kiyoshi Kawabata, Miyuki Kimura, Yuichi Sugiyama
Publikováno v:
Clinical Pharmacology & Therapeutics. 73:554-565
Objective Our objective was to quantitate the contribution of the genetic polymorphisms of the genes for 2 human organic anion transporters-organic anion transporting polypeptide C (OATP-C) and organic anion transporter 3 (OAT3)-to the pharmacokineti
Autor:
Noriko Okahashi, Kaoru Kikuchi, Yohei Nishizato, Masashi Yabuki, Takeshi Kunimatsu, Atsushi Yabunaka, Satoki Imai
Publikováno v:
Toxicology and applied pharmacology. 276(3)
SMP-028 is a drug candidate developed for the treatment of asthma. In a 13-week repeated dose toxicity study of SMP-028 in rats and monkeys, differences of endocrine toxicological events between rats and monkeys were observed. In rats, these toxicolo
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 24(2)
Steroidogenesis in the adrenals, testes, and ovaries plays an important roles in hormonal homeostasis in vivo and is mediated by various enzymes, such as acid cholesterol esterase (CEase), neutral CEase, CYP11A, 3beta-hydroxysteroid dehydrogenase (HS
Autor:
Yohei Nishizato, Hiroshi Suzuki, Miyuki Kimura, Kenji Otsubo, Akinori Urae, Ichiro Ieiri, Kiyoshi Kawabata, Hiroshi Takane, Shun Higuchi, Yuichi Sugiyama, Shin Irie
Publikováno v:
Hepatology research : the official journal of the Japan Society of Hepatology. 30(2)
To assess the contribution of OATP-C to the hepatobiliary transport of bilirubin, a pharmacogenomic evaluation with regard to polymorphisms of three candidate genes, OATP-C , MRP2 , and UGT1A1 , was performed. Serum total and direct (conjugated) bili