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Preparation of 2-aminosubstituted 3H-imidazo[4,5-c]quinolin-4(5H)-ones by palladium-assisted internal biaryl coupling reaction

Autor: Hiroyuki Nakahira, Yohei Ikuma

Publikováno v: Tetrahedron. 67:9509-9517

Representatives of the 3H-imidazo[4,5-c]quinolin-4(5H)-ones have shown interesting biological activity. We have found 2-aminosubstituted 3H-imidazo[4,5-c]quinolin-4(5H)-one as a potent dipeptidyl peptidase 4 inhibitor. However effective synthesis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f7ee3e72550ede5b6914f426f32af5f
https://doi.org/10.1016/j.tet.2011.10.015

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Synthesis of the tricyclic dihydrofuran moiety of azadirachtin: efficient transformation of the Claisen rearrangement intermediate into a functionalized tricyclic dihydrofuran core

Autor: Jun Ishihara, Susumi Hatakeyama, Akio Murai, Yohei Ikuma, Takanori Suzuki

Publikováno v: Tetrahedron. 59:10287-10294

Azadirachtin is a C-seco limonoid, derived from the neem tree. Previously, we reported the synthesis of the right and left segments of azadirachtin, in addition to the coupling reaction of the modeled ester utilizing Claisen rearrangement. Herein we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aafbe366f2dba3f701721446ccfb28b8
https://doi.org/10.1016/j.tet.2003.10.062

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Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: use of a carboxylate prodrug to improve bioavailability

Autor: Tomonori Kobayashi, Hiroyuki Nakahira, Katsuya Uchiyama, Takashi Umezome, Yohei Ikuma, Eiji Sugaru, Hidenori Kimura, Yuko Hirose, Hitoshi Hochigai, Naoyuki Sawada, Michiko Ono, Noriko Nunami, Jun Tadano, Yasumitsu Sakurai

Publikováno v: Bioorganicmedicinal chemistry. 23(4)

We have previously reported a novel series of 3H-imidazo[4,5-c]quinolin-4(5H)-ones with potent dipeptidyl peptidase IV (DPP-4) inhibitory activity. However, these compounds showed poor oral absorption. We attempted in this study esterification of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e51265faa7bb55b973e8f493c32c3e9
https://pubmed.ncbi.nlm.nih.gov/25596166

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Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors

Autor: Yudai Furuta, Hidenori Kimura, Hitoshi Hochigai, Tomonori Kobayashi, Kazuhiko Okazaki, Noriko Nunami, Yohei Ikuma, Hiroyuki Nakahira, Katsuya Uchiyama, Masakuni Horiguchi, Yasuhiro Sato, Yumi Masui, Mutsuko Sakai

Publikováno v: Bioorganicmedicinal chemistry. 20(19)

In recent years, dipeptidyl peptidase IV inhibitors have been noted as valuable agents for treatment of type 2 diabetes. Herein, we report the discovery of a novel potent DPP-4 inhibitor with 3H-imidazo[4,5-c]quinolin-4(5H)-one as skeleton. After eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e07d3fbddfed82a2b1a5cfefcc859b
https://pubmed.ncbi.nlm.nih.gov/22938786

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